Explore the vast range of titles available.

Background Different peripheral pathways are implicated in the regulation of the food ingestion‐digestion cycle. Methods Narrative review on gastrointestinal mechanisms involved in satiety and hunger signalling. Results Combined mechano‐ and chemoreceptors, peripherally released peptide hormones and neural pathways provide feedback to the brain to determine sensations of hunger (increase energy intake) or satiation (cessation of energy intake) and regulate the human metabolism. The gastric accommodation reflex, which consists of a transient relaxation of the proximal stomach during food intake, has been identified as a major determinant of meal volume, through activation of tension‐sensitive gastric mechanoreceptors. Motilin, whose release is the trigger of gastric Phase 3, has been identified as the major determinant of return of hunger after a meal. In addition, the release of several peptide hormones such as glucagon‐like peptide 1 (GLP‐1), cholecystokinin as well as motilin and ghrelin contributes to gut‐brain signalling with relevance to control of hunger and satiety. A number of nutrients, such as bitter tastants, as well as pharmacological agents, such as endocannabinoid receptor antagonists and GLP‐1 analogues act on these pathways to influence hunger, satiation and food intake. Conclusion Gastrointestinal mechanisms such as gastric accommodation and motilin release are key determinants of satiety and hunger.

In experiments on male Wistar rats, the stages of adaptive changes in the rhythm of periodic electrical activity in the small intestine during food deprivation were identified and the effect of GABA on changes of the rhythm under these conditions was assessed. It was found that on days 1-3 of food deprivation, the migrating myoelectric complex (MMC) in the small intestine is preserved, but the cycle becomes rarer. On days 4-6, MMC disappears, irregular and regular activity with no periods of quiescence is recorded. On days 7-9, predominantly irregular activity of the small intestine with short quiescence periods is observed. Enteral administration of GABA at different stages of food deprivation modulates electrical activity and preserves small intestinal MMC.

A photon avalanche (PA) effect that occurs in lanthanide-doped solids gives rise to a giant nonlinear response in the luminescence intensity to the excitation light intensity. As a result, much weaker lasers are needed to evoke such PAs than for other nonlinear optical processes. Photon avalanches are mostly restricted to bulk materials and conventionally rely on sophisticated excitation schemes, specific for each individual system. Here we show a universal strategy, based on a migrating photon avalanche (MPA) mechanism, to generate huge optical nonlinearities from various lanthanide emitters located in multilayer core/shell nanostructrues. The core of the MPA nanoparticle, composed of Yb 3+ and Pr 3+ ions, activates avalanche looping cycles, where PAs are synchronously achieved for both Yb 3+ and Pr 3+ ions under 852 nm laser excitation. These nanocrystals exhibit a 26th-order nonlinearity and a clear pumping threshold of 60 kW cm −2 . In addition, we demonstrate that the avalanching Yb 3+ ions can migrate their optical nonlinear response to other emitters (for example, Ho 3+ and Tm 3+ ) located in the outer shell layer, resulting in an even higher-order nonlinearity (up to the 46th for Tm 3+ ) due to further cascading multiplicative effects. Our strategy therefore provides a facile route to achieve giant optical nonlinearity in different emitters. Finally, we also demonstrate applicability of MPA emitters to bioimaging, achieving a lateral resolution of ~62 nm using one low-power 852 nm continuous-wave laser beam. A general mechanism, migrating photon avalanche, can generate large optical nonlinearity from various lanthanides emitters at the nanoscale.

The upper gastrointestinal (GI) tract undergoes a temporally coordinated cyclic motor pattern known as the migrating motor complex (MMC) in both dogs and humans during the fasted state. Feeding results in replacement of the MMC by a pattern of noncyclic, intermittent contractile activity termed as postprandial contractions. Although the MMC is known to be stimulated by motilin, recent studies have shown that ghrelin, which is from the same peptide family as motilin, is also involved in the regulation of the MMC. In the present study, we investigated the role of the vagus nerve on gastric motility using conscious suncus-a motilin- and ghrelin-producing small animal. During the fasted state, cyclic MMC comprising phases I, II, and III was observed in both sham-operated and vagotomized suncus; however, the duration and motility index (MI) of phase II was significantly decreased in vagotomized animals. Motilin infusion (50 ng·kg(-1)·min(-1) for 10 min) during phase I had induced phase III-like contractions in both sham-operated and vagotomized animals. Ghrelin infusion (0.1, 0.3, 1, 3, or 10 µg·kg(-1)·min(-1) for 10 min) enhanced the amplitude of phase II MMC in sham-operated animals, but not in vagotomized animals. After feeding, phase I was replaced by postprandial contractions, and motilin infusion (50 ng·kg(-1)·min(-1) for 10 min) did not induce phase III-like contractions in sham-operated suncus. However, in vagotomized suncus, feeding did not evoke postprandial contractions, but exogenous motilin injection strongly induced phase III-like contractions, as noted during the phase I period. Thus, the results indicate that ghrelin stimulates phase II of the MMC via the vagus nerve in suncus. Furthermore, the vagus nerve is essential for initiating postprandial contractions, and inhibition of the phase III-like contractions induced by motilin is highly dependent on the vagus nerve.

The migration of chemical compounds from packaging polymers to food presents a multifaceted challenge with implications for food safety and public health. This review explores the interaction between packaging materials and food products, focusing on permeation, migration, and sorption processes. The different migration mechanisms of contact migration, gas phase migration, penetration migration, set-off migration, and condensation/distillation migration have been discussed comprehensively. The major migrating compounds are plasticizers, nanoparticles, antioxidants, light stabilizers, thermal stabilizers, monomers, oligomers, printing inks, and adhesives, posing potential health risks due to their association with endocrine disruption and carcinogenic effects. Advanced analytical methods help in the monitoring of migrated compounds, facilitating compliance with regulatory standards. Regulatory agencies enforce guidelines to limit migration, prompting the development of barrier coatings and safer packaging alternatives. Furthermore, there is a need to decipher the migration mechanism for mitigating it along with advancements in analytical techniques for monitoring the migration of compounds.

Interpretation of bowel sounds (BS) provides a convenient and non-invasive technique to aid in the diagnosis of gastrointestinal (GI) conditions. However, the approach’s potential is limited by variation between BS and their irregular occurrence. A short, manual auscultation is sufficient to aid in diagnosis of only a few conditions. A longer recording has the potential to unlock additional understanding of GI physiology and clinical utility. In this paper, a low-cost and straightforward piezoelectric acoustic sensing device was designed and used for long BS recordings. The migrating motor complex (MMC) cycle was detected using this device and the sound index as the biomarker for MMC phases. This cycle of recurring motility is typically measured using expensive and invasive equipment. We also used our recordings to develop an improved categorization system for BS. Five different types of BS were extracted: the single burst, multiple bursts, continuous random sound, harmonic sound, and their combination. Their acoustic characteristics and distribution are described. The quantities of different BS during two-hour recordings varied considerably from person to person, while the proportions of different types were consistent. The sensing devices provide a useful tool for MMC detection and study of GI physiology and function.

This paper compares results from a whole atmosphere‐ionosphere coupled model, GAIA, with the COSMIC and TIMED/SABER observations during the 2008/2009 northern winter season. The GAIA model has assimilated meteorological reanalysis data by a nudging method. The comparison shows general agreement in the major features from the stratosphere to the ionosphere including the growth and decay of the major stratospheric sudden warming (SSW) event in 2009. During this period, a pronounced semidiurnal variation in the F region electron density and its local‐time phase shift similar to the previous observations are reproduced by the model and COSMIC observation. The model suggests that the electron density variation is caused by an enhanced semidiurnal variation in the E × B drift, which is probably related to an amplified semidiurnal migrating tide (SW2) in the lower thermosphere. The model and TIMED/SABER observation show that the SW2 tide amplifies at low latitudes from the stratosphere to the thermosphere as well as the phase variation. Possible mechanisms for the SW2 variability in the low latitude stratosphere could be the change of its propagation condition, especially the (2, 2) mode, due to changing zonal background wind and meridional temperature gradient, and/or an enhancement of its source due to redistribution of stratospheric ozone. Present results also show a prominent long‐term variation of the terdiurnal migrating component (TW3) in the ionosphere and atmosphere. Key Points Comparison of a whole atmosphere‐ionosphere model with satellite observations Role of semidiurnal migrating tide (SW2) during stratospheric sudden warming Mechanisms for amplification of SW2 during stratospheric warming

We investigate the excitation and variability of migrating and non-migrating diurnal and semi-diurnal tides in the mesosphere and lower thermosphere (MLT) during the 2021 Northern Hemisphere sudden stratospheric warming (SSW). Zonal wind data from MERRA-2 reanalysis are decomposed into tidal components using a two-dimensional least-squares harmonic fitting technique. The migrating diurnal tide (DW1) strengthens at low latitudes following the SSW onset, whereas the migrating semi-diurnal tide (SW2) intensifies at high latitudes. Non-migrating diurnal tides (D0, DW2, DW3) arise from nonlinear interactions between DW1 and stationary planetary waves (SPWs), while non-migrating semi-diurnal tides (SW1, SW3) are modulated by stratospheric ozone variability linked to planetary-wave activity. The zonally symmetric semi-diurnal tide (S0) responds primarily to dynamical perturbations associated with the SSW. Eastward non-migrating diurnal tides (DE2, DE3) correlate strongly with total precipitable water vapor (TPWV), indicating tropospheric latent-heat forcing, whereas DE1 exhibits weak coupling. These results reveal distinct, latitude-dependent excitation pathways connecting stratospheric and tropospheric dynamics to tidal variability in the MLT during major SSW events.

This study combines 8 years of middle atmospheric wind data observed at 52°N latitude from two radars in different longitudinal sectors to investigate solar tides. The power spectral density of horizontal winds exhibits a −3 power law within the frequency range 2.0 < f < 7.0 cpd (equivalent to periods 3.6 − 12.0 hr). Particularly noteworthy are the 4.8‐ and 4‐hr tides, exhibiting signal‐to‐noise ratios ranging between 13 and 16 dB, surpassing the 0.01 significance level. This challenges their previous oversight in literature, possibly due to inadequacies in prevailing noise models. Cross‐spectra between longitudinal sectors emphasize the dominance of sun‐synchronous components in the six lowest‐frequency tides. Composite spectra indicate that tidal enhancements during SSWs resemble regular seasonal variations. Intriguingly, year‐to‐year spectral variations suggest that these enhancements are more influenced by seasonal dynamics than by SSW, contrasting with established literature. These findings underscore the need to reevaluate tidal harmonics and consider appropriate noise models in future studies. Plain Language Summary Tides are ubiquitous in celestial systems, influencing celestial objects diversely when one orbits another. Extensive studies have explored the tidal effects on processes such as planetary habitability, climate fluctuations, meteorological patterns, geophysical activities, geological hazards, heat and mass circulation, and certain biological behaviors. However, most existing literature focuses on the lowest‐frequency tidal harmonics, with limited attention given to higher‐frequency ones. In the Earth's atmosphere, the exact count of solar tidal harmonics remains uncertain, and an ongoing debate persists regarding the existence of higher‐frequency harmonics, arising potentially from difficulties in distinguishing them from sporadic regional buoyancy waves. Here, we provide evidence for the statistically significant existence of the first six orders of tidal harmonics, extracted from 8 years of middle atmospheric wind observations. Spectral coherence between two distinct longitudinal sectors signifies that the six harmonics primarily correspond to sun‐synchronous tides synchronized with the Sun. The presence of higher‐frequency tides suggests that tidal effects are characterized by greater complexity than currently understood. Key Points Wind spectrum reveals 6 tidal harmonics significantly higher than background noise with −3 frequency power law Coherence between two longitudinal sectors reveals that the harmonics are synchronized with the Sun Winter tidal enhancements seem to be influenced by seasonal factors rather than SSW, presenting a contrast to existing literature

Industries are increasingly looking for opportunities at utilizing collaborative robots in assembly lines to perform the tasks independently or assist the human workers due to the advancement of industry 4.0 technologies. Purchasing cost is one of the important factors to be considered by production managers, while designing or redesigning assembly line when collaborative robots are being utilized. Several objectives are to be optimized in an assembly line balancing problem and optimizing line efficiency along with purchasing cost sometimes results in conflicting situation. This paper presents the first study to tackle the cost-oriented assembly line balancing problem with collaborative robots, where several different types of collaborative robots with different purchasing costs are available and selected. A multi-objective mixed-integer programming model is developed to minimize the cycle time and the total collaborative robot purchasing cost. The multi-objective migrating bird optimization algorithm is developed to obtain a set of high-quality Pareto solutions. This algorithm utilizes the fast non-dominated sorting approach to update the population and develops a restart mechanism to select one solution in the permanent Pareto archive to replace the abandoned solution which remains unchanged for several iterations. The computational study validates that the utilization of the multi-objective model is reasonable and developed algorithm produces competing performance in comparison with multi-objective non-dominated sorting genetic algorithm II, multi-objective simulated annealing algorithm and two multi-objective artificial bee colony algorithms.