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Isoperimetric inequalities in unbounded convex bodies
We consider the problem of minimizing the relative perimeter under a volume constraint in an unbounded convex body
eBook
Jennifer Post : pure space, elegant minimalism
This striking book showcases fresh, contemporary interiors that reflect Jennifer Post's \"pure space\" philosophy: a serene, meticulously organized volume that offers a peaceful break from a busy world. From lofts in New York City to Miami high-rises to Palm Beach villas, each interior is immaculately conceived, detailed, and constructed--the epitome of pure, tailored modernism.
Book
Triply periodic minimal surface (TPMS) porous structures: from multi-scale design, precise additive manufacturing to multidisciplinary applications
Inspired by natural porous architectures, numerous attempts have been made to generate porous structures. Owing to the smooth surfaces, highly interconnected porous architectures, and mathematical controllable geometry features, triply periodic minimal surface (TPMS) is emerging as an outstanding solution to constructing porous structures in recent years. However, many advantages of TPMS are not fully utilized in current research. Critical problems of the process from design, manufacturing to applications need further systematic and integrated discussions. In this work, a comprehensive overview of TPMS porous structures is provided. In order to generate the digital models of TPMS, the geometry design algorithms and performance control strategies are introduced according to diverse requirements. Based on that, precise additive manufacturing methods are summarized for fabricating physical TPMS products. Furthermore, actual multidisciplinary applications are presented to clarify the advantages and further potential of TPMS porous structures. Eventually, the existing problems and further research outlooks are discussed.
Journal Article
CREDIBLE RESEARCH DESIGNS FOR MINIMUM WAGE STUDIES
The authors assess the critique by Neumark, Salas, and Wascher (2014) of minimum wage studies that found small effects on teen employment. Data from 1979 to 2014 contradict NSW; the authors show that the disemployment suggested by a model assuming parallel trends across U.S. states mostly reflects differential pre-existing trends. A data-driven LASSO procedure that optimally corrects for state trends produces a small employment elasticity (–0.01). Even a highly sparse model rules out substantial disemployment effects, contrary to NSW’s claim that the authors discard too much information. Synthetic controls do place more weight on nearby states—confirming the value of regional controls—and generate an elasticity of 20.04. A similar elasticity (–0.06) obtains from a design comparing contiguous border counties, which the authors show to be good controls. NSW’s preferred matching estimates mix treatment and control units, obtain poor matches, and find the highest employment declines where the relative minimum wage falls. These findings refute NSW’s key claims.
Journal Article
White light : Heiberg Cummings Design
\"Norway and New York City-based interior designers Bernt Heiberg and Bill Cummings of Heiberg Cummings Design bring both an eye for Scandinavian minimalism and an appreciation for a traditional American aesthetic to each of their projects. Bernt and Bill value individual expression above all, and are profoundly inspired by their clients' own tastes and personalities. Whether reimagining a secluded home in the country or an apartment looking out over the skyline of Manhattan, the firm tailors each space to its unique inhabitants. With a flair for elegant details, their personal signature is a fusion of light, spaciousness, and muted colors that resonates with contemporary taste. This spirit is evident in this lavishly illustrated book, which includes a combination of formal essays and handwritten notes detailing Bernt and Bill's inspirations and thought processes, as well as snapshots of glamorous events and locations. The whimsical text combined with the vivid mix of color, black and white, and collage-style prints perfectly illustrate the eclectic style of this up and coming design firm\"--Amazon.com, viewed December 10, 2012.
Book
The gap between statistical and clinical significance: time to pay attention to clinical relevance in patient-reported outcome measures of insomnia
Background
Appropriately defining and using the minimal important change (MIC) and the minimal clinically important difference (MCID) are crucial for determining whether the results are clinically significant. The aim of this study is to survey the status of randomized controlled trials (RCTs) for insomnia interventions to assess the inclusion and interpretation of MIC/MCID values.
Methods
We conducted a cross-sectional study to survey the status of RCTs for insomnia interventions to assess the inclusion and appropriate interpretation of MIC/MCID values. A literature search was conducted by searching the main sleep medicine journals indexed in PubMed, the Excerpta Medica Database (EMBASE), and the Cochrane Central Register of Controlled Trials (CENTRAL) to identify a broad range of search terms. We included RCTs with no restriction on the intervention. The included studies used the Insomnia Severity Index (ISI) or the Pittsburgh Sleep Quality Index (PSQI) questionnaire as the outcome measures.
Results
81 eligible studies were identified, and more than one-third of the included studies used MIC/MCID (
n
= 31, 38.3%). Among them, 21 studies with ISI as the outcome used MIC defined as a relative decrease ranging from 3 to 8 points. The most frequently used MIC value was a 6-point decrease (
n
= 7), followed by 8-point (
n
= 6) and 7-point decrease (
n
= 4), a 4 to 5-points decrease (
n
= 3), and a 30% reduction from baseline; 6 studies used MCID values, ranging from 2.8 to 4 points. The most frequently used MCID value was a 4-point decrease in the ISI (
n
= 4). 4 studies with PSQI as the outcome used a 3-point change as the MIC (
n
= 2) and a 2.5 to 2.7-point difference as MCID (
n
= 2). 4 non-inferiority design studies considered interval estimation when drawing clinically significant conclusions in their MCID usage.
Conclusions
The lack of consistent MIC/MCID interpretation and usage in outcome measures for insomnia highlights the urgent need for further efforts to address this issue and improve reporting practices.
Journal Article
OEO Studio : the philosophy of compelling minimalism : Danish design infused with Japan
This visual journey originates from the inspiration that drives OEO's co-founders, Thomas Lykke and Anne-Marie Buemann, and offers a detailed exploration of their design philosophy known as Compelling Minimalism. This approach is characterized by disciplined restraint, attention to detail, coherence, and elegance, driven by a unique combination of Scandinavian values of clarity and a deep appreciation of Asian aesthetics.
BOOK
Liquid biopsy for therapy monitoring in early-stage non-small cell lung cancer
Liquid biopsy is now considered a valuable diagnostic tool for advanced metastatic non-small cell lung cancer (NSCLC). In NSCLC, circulating tumor DNA (ctDNA) analysis has been shown to increase the chances of identifying the presence of targetable mutations and has been adopted by many clinicians owing to its low risk. Serial monitoring of ctDNA may also help assess the treatment response or for monitoring relapse. As the presence of detectable plasma ctDNA post-surgery likely indicates residual tumor burden, studies have been performed to quantify plasma ctDNA to assess minimal residual disease (MRD) in early-stage resected NSCLC. Most data on utilizing liquid biopsy for monitoring MRD in early-stage NSCLC are from small-scale studies using ctDNA. Here, we review the recent research on liquid biopsy in NSCLC, not limited to ctDNA, and focus on novel methods such as micro RNAs (miRNA) and long non-coding (lncRNA).
Journal Article