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Supersymmetry and beyond : from the Higgs boson to the new physics
\"The epic story of the quest to uncover a fully unified theory of physics, revised to reflect the possible discovery of the Higgs Boson\"-- Provided by publisher.
Book
Effect of nano-hydroxyapatite and ozone on approximal initial caries: a randomized clinical trial
The aim of the study was to assess the efficacy of three methods of enamel remineralization on initial approximal caries: (1) a nano-hydroxyapatite gel, (2) gaseous ozone therapy, (3) combination of a nano-hydroxyapatite gel and ozone. Patients (n = 92, age 20–30 years) with initial approximal enamel lesions on premolar and molar teeth (n = 546) were randomly allocated to three groups subjected to a 6-months treatment: Group I: domestic nano-hydroxyapatite remineralizing gel, group II: in-office ozone therapy, group III: both domestic remineralizing gel and ozone therapy. Caries lesions were assessed on bitewing radiographs at baseline, after 1 year and after 2 years. At one-year follow-up, the smallest rate of lesions with remineralisation (36.5%) was found in group I, and the highest (69.3%)—in group III. In group III a significant remineralisation was noticed in after 1 year and then a demineralisation after 2 years. Thus nano-hydroxyapatite gel and ozone therapy exert some capacities to remineralize approximal enamel and dentine subsurface lesions of premolar and molar teeth. Moreover, the combination of both methods produces the best effect compared to nano-hydroxyapatite or ozone therapy applied alone. However, the treatment should be continued for a long time in order to achieve nonrestorative recovery of caries.
Journal Article
Nanotechnology in healthcare, and its safety and environmental risks
Nanotechnology holds immense promise in revolutionising healthcare, offering unprecedented opportunities in diagnostics, drug delivery, cancer therapy, and combating infectious diseases. This review explores the multifaceted landscape of nanotechnology in healthcare while addressing the critical aspects of safety and environmental risks associated with its widespread application. Beginning with an introduction to the integration of nanotechnology in healthcare, we first delved into its categorisation and various materials employed, setting the stage for a comprehensive understanding of its potential. We then proceeded to elucidate the diverse healthcare applications of nanotechnology, spanning medical diagnostics, tissue engineering, targeted drug delivery, gene delivery, cancer therapy, and the development of antimicrobial agents. The discussion extended to the current situation surrounding the clinical translation and commercialisation of these cutting-edge technologies, focusing on the nanotechnology-based healthcare products that have been approved globally to date. We also discussed the safety considerations of nanomaterials, both in terms of human health and environmental impact. We presented the in vivo health risks associated with nanomaterial exposure, in relation with transport mechanisms, oxidative stress, and physical interactions. Moreover, we highlighted the environmental risks, acknowledging the potential implications on ecosystems and biodiversity. Lastly, we strived to offer insights into the current regulatory landscape governing nanotechnology in healthcare across different regions globally. By synthesising these diverse perspectives, we underscore the imperative of balancing innovation with safety and environmental stewardship, while charting a path forward for the responsible integration of nanotechnology in healthcare.
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Journal Article
Green nanomaterials : sustainable technologies and applications
\"Recent technological advancements in green nanotechnology have opened a brand new avenue for research and development in the field of medicinal plants-mediated nanoparticles, biopolymer, biotechnology, and antimicrobial and biomedical research. This new volume, Green Nanomaterials: Sustainable Technologies and Applications, explores a number of eco-friendly technologies in green materials synthesis, which are of considerable importance. It takes an inter- and cross-multidisciplinary approach to the green chemistry of nanoengineering and green nanotechnology application in materials research. It provides informative coverage of this exciting and dynamic new field as well as relates the fundamentals of soft-nanomaterials fabrication and brand new spectroscopic integration. The book explores bio-inspired self-assembly green nanomaterials for multifunctional applications as well as the design and synthesis of green polymeric nanomaterials for a number of pharmaceutical and biomedical applications, including biosensors, drug delivery, antimicrobial applications, etc. Also discussed is the fabrication of green polymer nanocomposites from waste and natural fibers, such as chitin fiber, chitin whisker fiber, cellulose fiber, nano cellulose fiber, eggshells, and cotton waste. The book is a unique mixture of exclusive ideas from peer-reviewed papers, reports from the latest research newsletters, mini reviews, and invited papers on key developments in the field. It will be a helpful resource for scientists and researchers, industry professionals, and faculty and advanced students in this area\"-- Provided by publisher.
Book
Hierarchically porous Au nanostructures with interconnected channels for efficient mass transport in electrocatalytic CO₂ reduction
Electrocatalytic CO₂ reduction is a promising way to provide renewable energy from gaseous CO₂. The development of nanostructures improves energy efficiency and selectivity for value-added chemicals, but complex nanostructures limit the CO₂ conversion rates due to poor mass transport during vigorous electrolysis. Herein, we propose a three-dimensional (3D) hierarchically porous Au comprising interconnected macroporous channels (200–300 nm) and nanopores (∼10 nm) fabricated via proximity-field nanopatterning. The interconnected macropores and nanopores enable efficient mass transport and large active areas, respectively. The roles of each pore network are investigated using reliable 3D nanostructures possessing controlled pore distribution and size. The hierarchical nanostructured electrodes show a high CO selectivity of 85.8% at a low overpotential of 0.264 V and efficient mass activity that is maximum 3.96 times higher than that of dealloyed nanoporous Au. Hence, the systematic model study shows the proposed hierarchical nanostructures have important value in increasing the efficiency of expensive Au.
Journal Article
The visioneers : how a group of elite scientists pursued space colonies, nanotechnologies, and a limitless future
\"In 1969, Princeton physicist Gerard O'Neill began looking outward to space colonies as the new frontier for humanity's expansion. A decade later, Eric Drexler, an MIT-trained engineer, turned his attention to the molecular world as the place where society's future needs could be met using self-replicating nanoscale machines. These modern utopians predicted that their technologies could transform society as humans mastered the ability to create new worlds, undertook atomic-scale engineering, and, if truly successful, overcame their own biological limits. The Visioneers tells the story of how these scientists and the communities they fostered imagined, designed, and popularized speculative technologies such as space colonies and nanotechnologies. Patrick McCray traces how these visioneers blended countercultural ideals with hard science, entrepreneurship, libertarianism, and unbridled optimism about the future. He shows how they built networks that communicated their ideas to writers, politicians, and corporate leaders. But the visioneers were not immune to failure--or to the lures of profit, celebrity, and hype. O'Neill and Drexler faced difficulty funding their work and overcoming colleagues' skepticism, and saw their ideas co-opted and transformed by Timothy Leary, the scriptwriters of Star Trek, and many others. Ultimately, both men struggled to overcome stigma and ostracism as they tried to unshackle their visioneering from pejorative labels like \"fringe\" and \"pseudoscience.\" The Visioneers provides a balanced look at the successes and pitfalls they encountered. The book exposes the dangers of promotion--oversimplification, misuse, and misunderstanding--that can plague exploratory science. But above all, it highlights the importance of radical new ideas that inspire us to support cutting-edge research into tomorrow's technologies\"-- Provided by publisher.
Book
Mechano-bactericidal actions of nanostructured surfaces
Antibiotic resistance is a global human health threat, causing routine treatments of bacterial infections to become increasingly difficult. The problem is exacerbated by biofilm formation by bacterial pathogens on the surfaces of indwelling medical and dental devices that facilitate high levels of tolerance to antibiotics. The development of new antibacterial nanostructured surfaces shows excellent prospects for application in medicine as next-generation biomaterials. The physico-mechanical interactions between these nanostructured surfaces and bacteria lead to bacterial killing or prevention of bacterial attachment and subsequent biofilm formation, and thus are promising in circumventing bacterial infections. This Review explores the impact of surface roughness on the nanoscale in preventing bacterial colonization of synthetic materials and categorizes the different mechanisms by which various surface nanopatterns exert the necessary physico-mechanical forces on the bacterial cell membrane that will ultimately result in cell death.Newly developed antibacterial nanostructured surfaces show excellent prospects as next-generation biomaterials. In this Review, Ivanova, Stoodley and colleagues explore the different mechanisms by which various surface nanopatterns exert the necessary physico-mechanical forces on the bacterial cell membrane that will ultimately result in cell death.
Journal Article
Nanomaterials: certain aspects of application, risk assessment and risk communication
Development and market introduction of new nanomaterials trigger the need for an adequate risk assessment of such products alongside suitable risk communication measures. Current application of classical and new nanomaterials is analyzed in context of regulatory requirements and standardization for chemicals, food and consumer products. The challenges of nanomaterial characterization as the main bottleneck of risk assessment and regulation are presented. In some areas, e.g., quantification of nanomaterials within complex matrices, the establishment and adaptation of analytical techniques such as laser ablation inductively coupled plasma mass spectrometry and others are potentially suited to meet the requirements. As an example, we here provide an approach for the reliable characterization of human exposure to nanomaterials resulting from food packaging. Furthermore, results of nanomaterial toxicity and ecotoxicity testing are discussed, with concluding key criteria such as solubility and fiber rigidity as important parameters to be considered in material development and regulation. Although an analysis of the public opinion has revealed a distinguished rating depending on the particular field of application, a rather positive perception of nanotechnology could be ascertained for the German public in general. An improvement of material characterization in both toxicological testing as well as end-product control was concluded as being the main obstacle to ensure not only safe use of materials, but also wide acceptance of this and any novel technology in the general public.
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