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Background: Nerve conduction studies (NCS) are known to be influenced by various physiological and environmental factors. Region and population-specific normative reference values of NCS required for comparison and evaluation of results have been published in many research studies but the age-group-specific significant pattern of reference values is not available for the same. Researchers have agreed that results are variable by chronological age, the present study was carried out to determine the effect of aging on nerve conduction velocity (NCV) of two commonly tested median and ulnar nerves of upper limb in individuals of different age groups. Furthermore, the motive was to collect reference data that can be used during clinically significant diagnostic testing of nerves. Aims and Objectives: The study aimed to study the effect of aging on nerve conduction velocities of the median and ulnar nerve, as well as to observe the correlation of age and changes in NCS of the median and ulnar nerve. Materials and Methods: A cross-sectional (observational) study was conducted on 110 healthy individuals (count of males-60, females-50). The subjects for the study were taken up amongst the volunteers (medical students, teaching and nonteaching staff members in the Government Medical College and Rajindra Hospital, Patiala, and healthy volunteers who were willing to participate in the study). The subjects were grouped according to their age: Group I (18–30 years) (n = 38), Group II (31–45 years) (n = 38), and Group III (46–60 years) (n = 34). The motor and sensory distal latencies, amplitudes, and NCVs of median and ulnar nerves were recorded, and data were evaluated. Results: The mean and standard deviation of the median and ulnar nerve was studied for latencies, amplitude, and velocities for both sensory and motor components. Patients with older age had longer latencies (median: Motor and sensory P < 0.001, ulnar: Motor = 0.013 and sensory = 0.006), smaller amplitudes (median: Motor P = 0.013 and sensory <0.001, ulnar: Motor P = 0.014, and sensory = 0.008), and slower conduction velocities (median: Motor P < 0.001 and sensory = 0.006, ulnar: Motor P = 0.003 and sensory = 0.069) compared with the younger age group, and the change was well observed in the age group of ≥46 years. The change with age was greater in sensory nerve conduction of the median and ulnar nerves. Conclusion: Our study results demonstrate that age is significantly correlated with all three nerve conduction parameters recorded from both nerves. An age-matched comparison of the results obtained during routine testing should be made to increase the diagnostic sensitivity of NCS.

Background: Mobile phones and other touchscreen devices emit dangerous electromagnetic radiation that negatively affect nerve function, with the median nerve being the most vulnerable because it is mostly utilized for mobile phone typing. Nerve conduction studies (NCSs) can be used to successfully diagnose this change in nerve function NCS. Aims and Objectives: The goal of the study was to ascertain the impact of electromagnetic waves from mobile phones on the median nerve’s nerve conduction velocity (NCV). Materials and Methods: 150 young, healthy medical students participated in a cross-sectional (observational) study, and they were split into two groups based on how long they used their mobile phones: Group 1 (<30 min usage) and Group 2 (>30 min usage). The median nerves in both upper limbs were measured for their NCV, and the results were statistically analyzed using the student “t” test for equal variance for various parameters. Results: The research found that Group 1 participants, who use cell phones more frequently and for longer periods of time, had significantly reduced (impaired) sensory NCV of the median nerve. Conclusion: Smartphones and other touchscreen gadgets, depending on time of exposure and usage frequency, can negatively impact nerve function, resulting in a decrease in the median nerve’s conduction velocity, and this can be very efficiently diagnosed with the use of NCSs.

Diabetic peripheral neuropathy (DPN) is more common in people who have poor control of their blood glucose, and also who have problem with controlling their lipid profile, blood pressure, and body weight within normal range. [...]the recording is cumbersome and needs to be done only by trained personnel. The procedure is relatively costly. [...]the present study was undertaken to study the electrophysiological properties of peripheral nerves in patients suffering from T2DM and to observe the effect of different determinants of DPN on nerve conduction study considering NCS as gold standard for screening DPN. Group II comprised 25 cases without symptoms of peripheral neuropathy and Group III comprised 30 age, and body mass index (BMI) matched healthy subjects as control group.

Background and purpose Various electrodiagnostic criteria have been developed in Guillain–Barré syndrome (GBS). Their performance in a broad representation of GBS patients has not been evaluated. Motor conduction data from the International GBS Outcome Study (IGOS) cohort were used to compare two widely used criterion sets and relate these to diagnostic amyotrophic lateral sclerosis criteria. Methods From the first 1500 patients in IGOS, nerve conduction studies from 1137 (75.8%) were available for the current study. These patients were classified according to nerve conduction studies criteria proposed by Hadden and Rajabally. Results Of the 1137 studies, 68.3% (N = 777) were classified identically according to criteria by Hadden and Rajabally: 111 (9.8%) axonal, 366 (32.2%) demyelinating, 195 (17.2%) equivocal, 35 (3.1%) inexcitable and 70 (6.2%) normal. Thus, 360 studies (31.7%) were classified differently. The areas of differences were as follows: 155 studies (13.6%) classified as demyelinating by Hadden and axonal by Rajabally; 122 studies (10.7%) classified as demyelinating by Hadden and equivocal by Rajabally; and 75 studies (6.6%) classified as equivocal by Hadden and axonal by Rajabally. Due to more strictly defined cutoffs fewer patients fulfilled demyelinating criteria by Rajabally than by Hadden, making more patients eligible for axonal or equivocal classification by Rajabally. In 234 (68.6%) axonal studies by Rajabally the revised El Escorial (amyotrophic lateral sclerosis) criteria were fulfilled; in axonal cases by Hadden this was 1.8%. Conclusions and discussion This study shows that electrodiagnosis in GBS is dependent on the criterion set utilized, both of which are based on expert opinion. Reappraisal of electrodiagnostic subtyping in GBS is warranted.

Electrophysiological examination is important for the diagnosis and evaluation of nerve function in carpal tunnel syndrome (CTS). Electrophysiological severity classifications of CTS using a nerve conduction study (NCS) have been reported, and there are many reports on the relationship between severity classifications and clinical symptoms. The existing electrophysiological severity classifications have several problems, such as cases that do not fit into a classification and unclear reasons for the boundary value. The purpose of this study was to clarify the relationship between sensory nerve conduction velocity (SCV) and distal motor latency (DML) and to evaluate whether the existing severity classification method is appropriate. We created a scatter diagram between SCV and DML for our NCSs and found a negative correlation between SCV and DML (correlation coefficient, −0.786). When we applied our NCSs to the existing classifications (Padua and Bland classifications), there were many unclassifiable cases (15.2%; Padua classification), and the number of Grade 3 cases was significantly higher than that of Grade 2 or 4 cases (Bland classification). Our large dataset revealed a strong negative correlation between SCV and DML, indicating that the existing severity classifications do not always accurately reflect the severity of the disease.

This study investigates the impact of the anatomical separation point of the dorsal ulnar cutaneous nerve (DUCN) on nerve conduction studies (NCS). Involving 25 subjects with DUCN NCS findings, it utilizes ultrasound to mark the DUCN's divergence from the ulnar nerve. NCS was performed at four points relative to the separation point. The findings indicate the maximal amplitudes occurred 2 cm distal to the separation point. The study suggests it is ideal when the stimulation is performed between the seperation point and 2 cm distal to it.

Numerous nerve conduction tests are used for the electrodiagnosis of carpal tunnel syndrome (CTS), with a wide range of sensitivity and specificity reported for each test in clinical studies. The purpose of this study was to compare the diagnostic accuracy of various nerve conduction tests and determine the properties of the most accurate test. A prospective observational case control study. Eighty patients with clinically confirmed CTS and 80 asymptomatic healthy controls were included in the study. All patients underwent the routine hematological investigations as per the protocol. All cases and controls were subjected to various nerve conduction study protocols for CTS. Results were analyzed statistically. The two-tailed Student's t-test was used for the comparative statistical analysis. The sensitivity of each test was calculated as (the number of hands with an abnormal study result/the number of CTS hands) × 100. Comparison between percentages was performed by the McNemar test. The mean age was 38.19 ± 10.13 years and the female:male ratio was 1.5:1. The mean duration of disease was 0.89 ± 0.61 years. Hypothyroidism was present in 21 (26.25%) patients, whereas 13 (16.25%) and 4 (5%) patients had diabetes mellitus and rheumatoid arthritis, respectively. The median nerve motor latency was 4.73 ± 0.83 ms while the sensory latency was 3.44 ± 0.56 ms. The median nerve orthodomic sensory latency was found to be 2.57 ± 0.31 ms. The conduction velocity across the palm and wrist was 41.37 ± 0.67 ms. The sensitivity was the highest in the inching method (86.25%) and lowest for the conventional median motor and sensory latencies (56.25% and 45%, respectively). Addition of a single test of median and ulnar sensory latency, the median and radial sensory latency or the inching method, in routine protocol will improve the sensitivity for the diagnosis of CTS in all patients.

MRI is the most appropriate imaging method for visual evaluation of lumbosacral plexopathy (LSP) and a reference for comparing with nerve conduction study (NCS). Eight patients with clinical, electrophysiological, and lumbosacral plexus MRI findings suggestive of LSP were prospectively recruited. Saphenous nerve abnormalities were present in seven patients (88%), compared to three for the superficial fibular (38%), and three for the sural nerve (38%). MRI showed tumor, hematoma, abscess, contrast enhancement, or hyperintense signals on the T2-weighted sequences. The SN has the highest yield in MRI positive LSP and may be a vital adjunct for electrophysiological evaluation of LSP.

Background: Pregnancy-related carpal tunnel syndrome (PRCTS) is a persistent mononeuropathy in pregnancy. The incidence of PRCTS has a wide fluctuation range of 0.8% to 70%. Their incidence depends on the diagnostic technique. The nerve conduction study (NCS) is a very specific test for the diagnosis of PRCTS. There have been very few studies to compare the results of diagnosing PRCTS via NCS with clinical tests. Aims and Objectives: To assess the most reliable technique in the diagnosis of PRCTS by comparing clinical tests with the nerve conduction studies in electrodiagnostic (EDX) testing. Materials and Methods: As per inclusion and exclusion criteria, 100 subjects were included in the study. Out of 75 pregnant females, 25 were agematched non-pregnant females as controls. All were enrolled in the ANC clinic and gynecology outpatient department of Jawahar Lal Nehru Medical College and Hospital, AMU, Aligarh. All the females were assessed for CTS by the clinical tests as well as the EDX test performed in the department of physiology at JNMCH and AMU. The testing was done at the wrist joint in order to assess the normal functioning of the median nerve. Results: There was a highly significant difference between the two methods for the diagnosis of PRCTS. Out of the total 75 pregnant females enrolled, only 2 were found to be positive for PRCTS via clinical testing, whereas in the EDX techniques, 48% of the pregnant females were diagnosed as having PRCTS. Conclusion: Clinical tests are not emerging as a good method for PRCTS diagnosis, while EDX testing is the gold standard and a prudent method to diagnose PRCTS.

Background：To study lesions＇ location and prognosis of cubital tunnel syndrome （CubTS） by routine motor nerve conduction studies （MNCSs） and short-segment nerve conduction studies （SSNCSs,inching test）.Methods：Thirty healthy subjects were included and 60 ulnar nerves were studied by inching studies for normal values.Sixty-six patients who diagnosed CubTS clinically were performed bilaterally by routine MNCSs and SSNCSs.Follow-up for 1-year,the information of brief complaints,clinical symptoms,and physical examination were collected.Results：Sixty-six patients were included,88 of nerves was abnormal by MNCS,while 105 was abnormal by the inching studies.Medial epicondyle to 2 cm above medial epicondyle is the most common segment to be detected abnormally （59.09％）,P ＜ 0.01.Twenty-two patients were followed-up,17 patients＇ symptoms were improved.Most of the patients were treated with drugs and modification of bad habits.Conclusions：（1） SSNCSs can detect lesions of compressive neuropathy in CubTS more precisely than the routine motor conduction studies.（2） SSNCSs can diagnose CubTS more sensitively than routine motor conduction studies.（3） In this study,we found that medial epicondyle to 2 cm above the medial epicondyle is the most vulnerable place that the ulnar nerve compressed.（4） The patients had a better prognosis who were abnormal in motor nerve conduction time only,but not amplitude in compressed lesions than those who were abnormal both in velocity and amplitude.Our study suggests that SSNCSs is a practical method in detecting ulnar nerve compressed neuropathy,and sensitive in diagnosing CubTS.The compound muscle action potentials by SSNCSs may predict prognosis of CubTS.