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Contemporary studies largely concentrate on the physical aspects of architecture, yet within the sphere of design, the gap between user experience and the designer’s intention is an undeniable fact. This gap, illustrating the contrast between the spatial perception and the actual physical space, to some degree, mirrors preferences in human spatial behavior. It accentuates the complex relationship between human cognitive functions and spatial layout, underlining the critical role of spatial perception in architectural design and planning. This prompts the question of whether perceptions of internal traffic flow within buildings also suffer from spatial distortions. Focusing on museums, and by examining circulation paths and spatial features, a virtual museum model is devised. The research employs a holistic and reductionist approach (complex systems theory) to forge a link between circulation components and the spatial experience of architecture. Utilizing agent-based modeling tools for simulating pedestrian movements, it investigates how different circulation patterns and spatial relationships influence pedestrian behavior. The study proposes a museum circulation optimization strategy, grounded in quantifying spatial experience through Anylogic software analysis. This strategy is aimed at enhancing the design of internal traffic flows in future museum projects, offering fresh insights into museum design research, and probing into new possibilities for using pedestrian simulation software.

Accurate indoor occupancy information extraction plays a crucial role in building energy conservation. Vision-based methods are popularly used for occupancy information extraction because of their high accuracy. However, previous vision-based methods either only provide 2D occupancy information or require expensive equipment. In this paper, we propose a cost-effective indoor occupancy information extraction system that estimates occupant positions and trajectories in 3D using a single RGB camera. The proposed system provides an inverse proportional model to estimate the distance between a human head and the camera according to pixel-heights of human heads, eliminating the dependence on expensive depth sensors. The 3D position coordinates of human heads are calculated based on the above model. The proposed system also associates the 3D position coordinates of human heads with human tracking results by assigning the 3D coordinates of human heads to the corresponding human IDs from a tracking module, obtaining the 3D trajectory of each person. Experimental results demonstrate that the proposed system successfully calculates accurate 3D positions and trajectories of indoor occupants with only one surveillance camera. In conclusion, the proposed system is a low-cost and high-accuracy indoor occupancy information extraction system that has high potential in reducing building energy consumption.

Two new crystal structures of Bacillus stearothermophilus tryptophanyl-tRNA synthetase (TrpRS) afford evidence that a closed interdomain hinge angle requires a covalent bond between AMP and an occupant of either pyrophosphate or tryptophan subsite. They also are within experimental error of a cluster of structures observed in a nonequilibrium molecular dynamics simulation showing partial active-site assembly. Further, the highest energy structure in a minimum action pathway computed by using elastic network models for Open and Pretransition state (PreTS) conformations for the fully liganded TrpRS monomer is intermediate between that simulated structure and a partially disassembled structure from a nonequilibrium molecular dynamics trajectory for the unliganded PreTS. These mutual consistencies provide unexpected validation of inferences drawn from molecular simulations.