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Despite considerable efforts in the field of nanomedicine that have been made by researchers, funding agencies, entrepreneurs, and the media, fewer nanoparticle (NP) technologies than expected have made it to clinical trials. The wide gap between the efforts and effective clinical translation is, at least in part, due to multiple overlooked factors in both in vitro and in vivo environments, a poor understanding of the nano–bio interface, and misinterpretation of the data collected in vitro, all of which reduce the accuracy of predictions regarding the NPs’ fate and safety in humans. To minimize this bench-to-clinic gap, which may accelerate successful clinical translation of NPs, this opinion paper aims to introduce strategies for systematic debugging of nano–bio interfaces in the current literature. Critical information on nano–bio interfaces (e.g., biomolecular corona) and cells, including their sex, type, size, and passage number, should be considered. Standardization communities should propose standard units for nanoparticle dosage. Mathematical and computational approaches should be developed to define underlying mechanisms at the nano–bio interfaces. Interlaboratory comparison of characterization of nanoparticles, nano–bio interfaces, nanotoxicities, therapeutic efficacies, and others should be conducted to prevent conflicts produced by different instruments. Researchers, various well-established laboratories, funding agencies, entrepreneurs, and the media should work closely to prepare reliable and precise data sets, not only to prevent further clutter in the nanomedicine literature but also to accelerate successful clinical translation of nanomedicine.

The process of nitrite-dependent anaerobic methane oxidation (n-damo) was recently discovered and shown to be mediated by \"Candidatus Methylomirabilis oxyfera\" (M. oxyfera). Here, evidence for n-damo in three different freshwater wetlands located in southeastern China was obtained using stable isotope measurements, quantitative PCR assays, and 16S rRNA and particulate methane monooxygenase gene clone library analyses. Stable isotope experiments confirmed the occurrence of n-damo in the examined wetlands, and the potential n-damo rates ranged from 0.31 to 5.43 nmol CO2 per gram of dry soil per day at different depths of soil cores. A combined analysis of 16S rRNA and particulate methane monooxygenase genes demonstrated that M. oxyfera-like bacteria were mainly present in the deep soil with a maximum abundance of 3.2 × 107 gene copies per gram of dry soil. It is estimated that ∼0.51 g of CH4 m-2 per year could be linked to the n-damo process in the examined wetlands based on the measured potential n-damo rates. This study presents previously unidentified confirmation that the n-damo process is a previously overlooked microbial methane sink in wetlands, and n-damo has the potential to be a globally important methane sink due to increasing nitrogen pollution.

The role of the ‘file drawer’ problem in nanomedicine, which partly drives the current limited clinical success of therapeutic nanoparticles, has been poorly investigated. We propose an integrated functioning of all stakeholders as the only effective way to address the file drawer problem in an efficient and timely manner.

Real living wages (RLWs) are an important ethical and moral policy to ensure that employees earn enough to live on. In providing ‘a fair day's pay for a fair day's work’, they set an ethical foundation for liveability. This article explores the ethics and moral economy of the RLW for lower-paid staff in the overlooked economy context of UK professional football, illustrated by a qualitative case study of Luton Town Football Club (LTFC). The article provides theoretical insights grounded in moral economy concepts about how a RLW contributes to a broader common good means of enabling fuller human participation in decent working and living conditions. Applying these concepts using a multi-disciplinary moral economy interpretation offers deeper theoretical contributions than economistic interpretations restricted to mainly technocratic economic distributive issues. LTFC are evidently ethically embedded in a moral economy as a local community club paying a RLW, and part of the overlooked economy. The research also contributes to contemporary debates on ‘Common Good’ HRM regarding the role of living wages in addressing grand common good challenges like inequality and quality of working lives.

[...]the search for repurposing candidates combines traditional and modern tools, including but not limited to computational analysis and database searches (i.e., utilizing public databases such as medical journals, regulatory agency archives, and patient advocacy group reports); newer experimental approaches (i.e., testing drug interactions in novel contexts); artificial intelligence and bioinformatics tools (i.e., advanced algorithms explore potential drug-protein interactions, integrating pharmacological data with genetics, pharmacogenomics, biological pathways, and diagnostic/prognostic insights). The authors explored an integrated drug repurposing method, including disease similarity and chemical similarity as multi-similarity analysis approaches, molecular docking and molecular dynamic simulation methods as structure-based screening approaches, and network proximity analysis, in which they quantified the network distance between the disease module of PIV3 and the drug targets to probe the potential anti-PIV3 drugs. Using the aforementioned method, they confirmed that oseltamivir is the best potential drug against PIV3. [...]they recommend considering oseltamivir for clinical application in children. Fatemi et al.provided a comprehensive review of research efforts, and examples of drugs repurposing in different types of gastrointestinal cancers, such as colorectal, pancreatic, and liver cancer. [...]the authors have addressed several barriers for drug repurposing for cancer therapy, including the legal, regulatory, patent issues and financial factors. [...]some authors advocate for additional public funding as well as increased harmonization and centralization of such clinical research activities (Verbaanderd et al., 2021).

We investigated the globally distributed red algal genus Pterocladiella , comprising 24 described species, many of which are economically important sources of agar and agarose. We used DNA-based species delimitation approaches, phylogenetic, and historical biogeographical analyses to uncover cryptic diversity and infer the drivers of biogeographic patterns. We delimited 43 species in Pterocladiella , of which 19 are undescribed. Our multigene time-calibrated phylogeny and ancestral area reconstruction indicated that Pterocladiella most likely originated during the Early Cretaceous in the Tethys Sea. Ancient Tethyan vicariance and long-distance dispersal have shaped current distribution patterns. The ancestor of Eastern Pacific species likely arose before the formation of the formidable Eastern Pacific Barrier—a first confirmation using molecular data in red algae. Divergences of Northeast and Southeast Pacific species have been driven by the Central American Seaway barrier, which, paradoxically, served as a dispersal pathway for Atlantic species. Both long- and short-distance dispersal scenarios are supported by genetic relationships within cosmopolitan species based on haplotype analysis. Asymmetrical distributions and the predominance of peripatry and sympatry between sister species suggest the importance of budding speciation in Pterocladiella . Our study highlights the underestimation of global diversity in these crucial components of coastal ecosystems and provides evidence for the complex evolution of current species distributions.

This special issue is devoted to highlighting thinkers who have been overlooked within business ethics and who have important contributions to make to our field. We make the case that, as scholars of a hybrid discipline that also aims to address important issues of business practice, we need to look continually for new sources of insight and wisdom that can both enrich our discourse and improve our ability to generate ideas that have a positive impact on business practice. In this introductory essay, we discuss our rationale for creating this special issue, summarize the articles contained within, and close with thoughts on its significance for the field going forward.

NOABSTRACTPolicies have often, albeit inadvertently, overlooked certain scientific insights, especially in the handling of complex events. This study aims to systematically uncover and evaluate pivotal scientific insights that have been underrepresented in policy documents by leveraging extensive datasets from policy texts and scholarly publications.This article introduces a research framework aimed at excavating scientific insights that have been overlooked by policy, encompassing four integral parts: data acquisition and preprocessing, the identification of overlooked content through thematic analysis, the discovery of overlooked content via keyword analysis, and a comprehensive analysis and discussion of the overlooked content. Leveraging this framework, the research conducts an in-depth exploration of the scientific content overlooked by policies during the COVID-19 pandemic.During the COVID-19 pandemic, scientific information in four domains was overlooked by policy: psychological state of the populace, environmental issues, the role of computer technology, and public relations. These findings indicate a systematic underrepresentation of important scientific insights in policy.This study is subject to two key limitations. Firstly, the text analysis method—relying on pre-extracted keywords and thematic structures—may not fully capture the nuanced context and complexity of scientific insights in policy documents. Secondly, the focus on a limited set of case studies restricts the broader applicability of the conclusions across diverse situations.The study introduces a quantitative framework using text analysis to identify overlooked scientific content in policy, bridging the gap between science and policy. It also highlights overlooked scientific information during COVID-19, promoting more evidence-based and robust policies through improved science-policy integration.This paper provides new ideas and methods for excavating scientific information that has been overlooked by policy, further deepens the understanding of the interaction between policy and science during the COVID-19 period, and lays the foundation for the more rational use of scientific information in policy-making.

Background During laparoscopic left hemicolectomy procedures, a previously overlooked consistently thick blood vessel within the gastrocolic ligament near the splenic hilum may contribute to post-operative bleeding complications. The purpose of this study was to investigate the identification and management of the previously overlooked blood vessel. Methods This is a retrospective descriptive study of patients undergoing laparoscopic left colectomy for splenic fexure cancer conducted at a national gastrointestinal surgery centre in China. Consecutive patients with splenic fexure cancer who underwent laparoscopic left colectomy using our“five-step process”( n  = 34) between January 2021 and July 2023 were included. Results The vessels can be effectively exposed using the aforementioned “five-step process.” It was observed that the overlooked vessels consistently present in all patients were identified as the omental branch of the left gastroepiploic artery and vein. Conclusion We have identified the origin of previously overlooked blood vessels and recommended a safe method for their management. This may offer advantages to colorectal surgeons performing laparoscopic left colectomy for splenic flexure cancer

Strongyloides stercoralis infections are rare causes of protein‐losing enteropathy and must be considered in the differential diagnosis of patients who present with peripheral edema due to hypoproteinemia, especially in endemic countries. Stool routine examination in such individuals is a simple but essential way of identifying this organism.