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"persistence"
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Energy expenditure and cellular activity underlie antibiotic tolerance of Pseudomonas aeruginosa
Recalcitrant bacterial infections are a continued burden on the healthcare system. Antibiotic treatment failure, especially for chronic infections, can be attributed to persisters, a subpopulation of dormant cells that survive a lethal dose of drug. The infection of cystic fibrosis (CF) airways by Pseudomonas aeruginosa is often incurable to treatment by multiple classes of antibiotics due to the presence of persisters. P. aeruginosa , however, is highly susceptible to antibiotic killing in vitro , in apparent contradiction of its drug tolerance during infection. Here, we show that P. aeruginosa susceptibility to antibiotic killing is due to its continued protein synthesis and cellular activity even with entrance into stationary phase. Furthermore, we identify that the greater energetic demand of biofilm growth generates a larger fraction of low-translating persisters and increases antibiotic tolerance. These findings improve our understanding of P. aeruginosa antibiotic tolerance during CF infection and will aid the development of better treatment regimens.
Journal Article
Gymnastics jump
Lily is performing in her first gymnastics meet, and her routines begin well, but she falls off the balance beam--however she does not quit, but gets back up and finishes her performance.
Book
Phase-plastic aggresomes as tunable regulators of bacterial dormancy depth
Bacterial persistence, a major clinical challenge in chronic and biofilm-associated infections, is driven by a dormant subpopulation capable of surviving antibiotic treatment without acquiring genetic resistance. This review summarizes recent advances supporting a unifying model in which phase-plastic aggresomes-protein-RNA condensates formed via liquid-liquid phase separation-function as tunable regulators of bacterial dormancy depth. We propose that the material state of aggresomes, ranging from liquid-like to gel-like, governs cellular recovery kinetics by modulating the sequestration and availability of core cellular machinery. Under stress, aggresomes dynamically assemble in response to triggers such as ATP depletion and macrophage-derived reactive oxygen species, enabling metabolic arrest while preserving viability. Their composition evolves over time, initially favoring reversible components that support shallow dormancy, then maturing into more gel-like states that deepen dormancy and delay resuscitation. This physical continuum allows bacteria to adaptively manage fitness trade-offs between survival and recovery. We further explore how aggresome plasticity opens new therapeutic avenues for bacterial persistence, including strategies to dissolve or solidify these condensates. Understanding aggresomes as adaptive organelles offers a transformative perspective on bacterial persistence and identifies novel targets for combating recalcitrant infections.
Journal Article
Good job, Ajay!
Ajay's friends encourage him as he practices throwing a ball. Includes questions about the text and notes to parents on visual learning.
Book
College Students' Sense of Belonging: A National Perspective
In a nationally representative sample, first-year U.S. college students \"somewhat agree,\" on average, that they feel like they belong at their school. However, belonging varies by key institutional and student characteristics; of note, racialethnic minority and first-generation students report lower belonging than peers at 4-year schools, while the opposite is true at 2-year schools. Further, at 4-year schools, belonging predicts better persistence, engagement, and mental health even after extensive covariate adjustment. Although descriptive, these patterns highlight the need to better measure and understand belonging and related psychological factors that may promote college students' success and well-being.
Journal Article
Nevertheless, we persisted : 48 voices of defiance, strength, and courage
\"A powerful collection of essays from actors, activists, athletes, politicians, musicians, writers, and teens, including Senator Amy Klobuchar, actress Alia Shawkat, actor Maulik Pancholy, poet Azure Antoinette, teen activist Gavin Grimm, and many, many more, each writing about a time in their youth when they were held back because of their race, gender, or sexual identity--but persisted\"--Provided by publisher.
Book
Professional role confidence and gendered persistence in engineering
\"Social psychological research on gendered persistence in science, technology, engineering, and mathematics (STEM) professions is dominated by two explanations: women leave because they perceive their family plans to be at odds with demands of STEM careers, and women leave due to low self-assessment of their skills in STEM's intellectual tasks, net of their performance. This study uses original panel data to examine behavioral and intentional persistence among students who enter an engineering major in college. Surprisingly, family plans do not contribute to women's attrition during college but are negatively associated with men's intentions to pursue an engineering career. Additionally, math self-assessment does not predict behavioral or intentional persistence once students enroll in a STEM major. This study introduces professional role confidence -- individuals' confidence in their ability to successfully fulfill the roles, competencies, and identity features of a profession -- and argues that women's lack of this confidence, compared to men, reduces their likelihood of remaining in engineering majors and careers. We find that professional role confidence predicts behavioral and intentional persistence, and that women's relative lack of this confidence contributes to their attrition.\" (Author's abstract, IAB-Doku). Die Untersuchung enthält quantitative Daten. Forschungsmethode: empirisch-quantitativ; empirisch; Längsschnitt. Die Untersuchung bezieht sich auf den Zeitraum 2003 bis 2007.
Journal Article
She's got this
\"Even Olympians have to start somewhere. And in this illustrated book, Laurie Hernandez tells the story of Zoe, a little girl who dreams of flying--and becoming a gymnast. When Zoe sees a gymnast on TV, she realizes that gymnastics is just like flying. But when she first goes to class and falls off the balance beam, she discovers that following her dreams is harder and scarier than she thought. Featuring vibrant art from Nina Mata, Laurie imparts important lessons she learned on her way to Olympic glory: You always have to get back up and try again, and you always have to believe in yourself\"-- Provided by publisher.
BOOK
Testing the three-way interaction effect of academic stress, academic self-efficacy, and task value on persistence in learning among Korean college students
Persistence is an important indicator of academic success in higher education. Academic stress, which influences individuals' learning motivation and behaviors, is inevitable in college life; however, individuals handle it differently based on their expectancy and value beliefs. In this study, academic stress, academic self-efficacy, and task value were chosen as predictors of persistence in learning, and the joint relationship between them was examined. The sample comprised 483 Korean college students. A multiple regression analysis was performed. The results revealed significant main and interaction effects, including a three-way interaction effect of academic stress, academic self-efficacy, and task value on persistence in learning. Particularly, students with strong motivation were less affected by a stressful and demanding environment. Furthermore, academic stress did not appear to be an exclusively negative factor and could be a catalyst to boost persistence in some conditions. Implications of the findings for promoting persistence in learning are discussed. (HRK / Abstract übernommen).
Journal Article