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Reliability of sub-surface defects is imperative for safer functionality of critical materials/components/structures used in a wide variety of applications in various industries. The need for reliable, fast, remote, safe inspection and evaluation methods for detecting hidden defects increases in parallel with the demand for more sustainable solutions, which helps in inherent design and manufacturing specifications modifications. During in-service operations, the hidden defects typically originated from various loading conditions leading to catastrophic failure. This work explores the best possible reliable, fast, remote, and safe inspection and evaluation experimental method and the associated post-processing approach using InfraRed Imaging (IRI) for Thermal Non-Destructive Testing and Evaluation of mild steel materials. This proposed work provides an insight into the state-of-the-art research in the field of thermal/infrared non-destructive testing and evaluation methods and associated post processing approach to visualize the hidden subsurface defects not only resolved by spatial thermal gradients but also simultaneously provide temporal thermal gradients at the defective regions.

Strontium silicates doped with an alkali metal are extensively investigated after their high conductivity reported in the moderate range of temperature (773 K < T < 1073 K). This work aims to study the structural, microstructural, morphological, thermal, and electrical investigation of Sr 3-3x Na 3x Si 3-3y Ge 3y O 9-δ (0 <  x  < 0.20, y  = 0.1; SNSG) system. A solid-state reaction method was adopted for synthesis of the compositions. Composition's phase formation was examined using X-rays Rietveld refinement techniques. X-Ray Diffraction (XRD) patterns were mapped by the monoclinic symmetry having space-group C12/c1. Moreover, along with monoclinic phase a few minor peaks of Sr 2 SiO 4 were also detected along with prominent peaks of parent SrSiO 3 . To comprehend the surface morphology of the compositions, scanning electron microscopy has been employed. Studies using Fourier transform infrared spectroscopy and Raman spectroscopy have been carried out to investigate the characteristic bands and vibrations modes of the system. Characteristic valence states of constituent elements and stability of the sintered samples in air were confirmed by the X-ray Photoelectron Spectroscopy (XPS) analysis. The electrical behavior of this system was studied by electrochemical impedance spectroscopy (EIS) techniques. Electrical conductivity of the platinum-coated sintered pellet samples was also calculated to check its feasibility as a cost-effective electrolyte for intermediate temperature range. It has also been observed that in Na-doped compositions, a few amorphous phases of Sodium silicate (Na 2 Si 2 O 5 ) formed as impurity that may contribute to the total conductivity. Graphical Abstract

Background Whole grains (WG) and fruits and vegetables (FV) have been shown to reduce the risk of metabolic disease, possibly via modulation of the gut microbiota. The purpose of this study was to determine the impact of increasing intake of either WG or FV on inflammatory markers and gut microbiota composition. Methods A randomized parallel arm feeding trial was completed on forty-nine subjects with overweight or obesity and low intakes of FV and WG. Individuals were randomized into three groups (3 servings/d provided): WG, FV, and a control (refined grains). Stool and blood samples were collected at the beginning of the study and after 6 weeks. Inflammatory markers [tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), lipopolysaccharide binding protein (LBP), and high sensitivity C-reactive protein (hs-CRP)] were measured. Stool sample analysis included short/branched chain fatty acids (S/BCFA) and microbiota composition. Results There was a significant decrease in LBP for participants on the WG (− 0.2 μg/mL, p  = 0.02) and FV (− 0.2 μg/mL, p  = 0.005) diets, with no change in those on the control diet (0.1 μg/mL, p  = 0.08). The FV diet induced a significant change in IL-6 (− 1.5 pg/mL, p  = 0.006), but no significant change was observed for the other treatments (control, − 0.009 pg/mL, p  = 0.99; WG, − 0.29, p  = 0.68). The WG diet resulted in a significant decrease in TNF-α (− 3.7 pg/mL; p  < 0.001), whereas no significant effects were found for those on the other diets (control, − 0.6 pg/mL, p  = 0.6; FV, − 1.4 pg/mL, p  = 0.2). The treatments induced individualized changes in microbiota composition such that treatment group differences were not identified, except for a significant increase in α-diversity in the FV group. The proportions of Clostridiales (Firmicutes phylum) at baseline were correlated with the magnitude of change in LBP during the study. Conclusions These data demonstrate that WG and FV intake can have positive effects on metabolic health; however, different markers of inflammation were reduced on each diet suggesting that the anti-inflammatory effects were facilitated via different mechanisms. The anti-inflammatory effects were not related to changes in gut microbiota composition during the intervention, but were correlated with microbiota composition at baseline. Trial registration ClinicalTrials.gov , NCT02602496 , Nov 4, 2017.

Acute phase proteins highlight the dynamic interaction between inflammation and oncogenesis. GlycA, a novel nuclear magnetic resonance (NMR) inflammatory marker that identifies primarily circulating N-acetyl glycan groups attached to acute phase proteins, may be a future CRC risk biomarker. We examined the association between GlycA and incident CRC and mortality in two prospective cohorts (N = 34,320); Discovery cohort: 27,495 participants from Women's Health Study (WHS); Replication cohort: 6,784 participants from Multi-Ethnic Study of Atherosclerosis (MESA). Multivariable Cox models were adjusted for clinical risk factors and compared GlycA to acute phase proteins (high-sensitivity C-reactive protein [hsCRP], fibrinogen, and soluble intercellular adhesion molecule-1 [sICAM-1]). In WHS (median follow-up 19 years, 337 cases, 103 deaths), adjusted HRs (95% CIs) per SD increment of GlycA for CRC incidence and mortality were 1.19 (1.06-1.35; p = 0.004) and 1.24 (1.00-1.55; p = 0.05), respectively. We replicated findings in MESA (median follow-up 11 years, 70 cases, 23 deaths); HRs (95% CIs) per SD of GlycA for CRC incidence and mortality were 1.32 (1.06-1.65; p = 0.01) and 1.54 (1.06-2.23; p = 0.02), respectively, adjusting for age, sex, and race. Pooled analysis, adjusted HR (95% CI) per SD of GlycA for CRC incidence and mortality was 1.26 (1.15-1.39; p = 1 x 10-6). Other acute phase proteins (hsCRP, fibrinogen, and sICAM-1) had weaker or no association with CRC incidence, while only fibrinogen and GlycA were associated with CRC mortality. The clinical utility of GlycA to personalize CRC therapies or prevention warrants further study. ClinicalTrials.gov: WHS NCT00000479, MESA NCT00005487.

Microstructure, phase composition and mechanical properties of a refractory high entropy superalloy, AlMo0.5NbTa0.5TiZr, are reported in this work. The alloy consists of a nano-scale mixture of two phases produced by the decomposition from a high temperature body-centered cubic (BCC) phase. The first phase is present in the form of cuboidal-shaped nano-precipitates aligned in rows along -type directions, has a disordered BCC crystal structure with the lattice parameter a1 = 326.9 ± 0.5 pm and is rich in Mo, Nb and Ta. The second phase is present in the form of channels between the cuboidal nano-precipitates, has an ordered B2 crystal structure with the lattice parameter a2 = 330.4 ± 0.5 pm and is rich in Al, Ti and Zr. Both phases are coherent and have the same crystallographic orientation within the former grains. The formation of this modulated nano-phase structure is discussed in the framework of nucleation-and-growth and spinodal decomposition mechanisms. The yield strength of this refractory high entropy superalloy is superior to the yield strength of Ni-based superalloys in the temperature range of 20 °C to 1200 °C.

Coal ash-based geopolymers with mine tailings addition activated with phosphate acid were synthesized for the first time at room temperature. In addition, three types of aluminosilicate sources were used as single raw materials or in a 1/1 wt. ratio to obtain five types of geopolymers activated with H3PO4. The thermal behaviour of the obtained geopolymers was studied between room temperature and 600 °C by Thermogravimetry-Differential Thermal Analysis (TG-DTA) and the phase composition after 28 days of curing at room temperature was analysed by X-ray diffraction (XRD). During heating, the acid-activated geopolymers exhibited similar behaviour to alkali-activated geopolymers. All of the samples showed endothermic peaks up to 300 °C due to water evaporation, while the samples with mine tailings showed two significant exothermic peaks above 400 °C due to oxidation reactions. The phase analysis confirmed the dissolution of the aluminosilicate sources in the presence of H3PO4 by significant changes in the XRD patterns of the raw materials and by the broadening of the peaks because of typically amorphous silicophosphate (Si–P), aluminophosphate (Al–P) or silico-alumino-phosphate (Si–Al–P) formation. The phases resulted from geopolymerisation are berlinite (AlPO4), brushite (CaHPO4∙2H2O), anhydrite (CaSO4) or ettringite as AFt and AFm phases.

Mixed venous and arterial ulcers account for approximately 15%-30% of all venous leg ulcerations. Several studies have shown that matrix metalloproteinases (MMPs) and neutrophil gelatinase-associated lipocalin (NGAL) play a central role in the pathophysiology of venous and arterial diseases. Some studies have shown the efficacy of glycosaminoglycans, such as sulodexide (SDX), in treating patients with leg ulcers. The aim of this study was to evaluate clinical effects of SDX and its correlation with MMPs and NGAL expression in patients with mixed arterial and venous leg ulcers. Patients eligible for this study were of both sexes, older than 20 years, and with a clinical and instrumental diagnosis of mixed ulcer. Fifty-three patients of both sexes were enrolled and divided into two groups by means of randomization tables. Group A (treated group) comprised 18 females and ten males (median age: 68.7 years) treated with standard treatment (compression therapy and surgery) + SDX (600 lipoprotein lipase-releasing units/day intramuscularly) for 15 days followed by SDX 250 lipase-releasing units every 12 hours day orally for 6 months as adjunctive treatment. Group B (control group) comprised 17 females and eight males (median age: 64.2 years) treated with standard treatment only (compression therapy and surgery). The type of surgery was chosen according to anatomical level of vein incompetence: superficial venous open surgery and/or subfascial endoscopic perforating surgery. In all enrolled patients, blood samples were collected in order to evaluate the plasma levels of MMPs and NGAL through enzyme-linked immunosorbent assay. These results were compared to another control group (Group C) of healthy individuals. Moreover, biopsies of ulcers were taken to evaluate the tissue expression of MMPs and NGAL through Western blot analysis. Our results revealed that SDX treatment is able to reduce both plasma levels and tissue expression of MMPs improving the clinical conditions in patients with mixed ulcers. Inhibition of MMPs could represent a possible therapeutic intervention to limit the progression of leg ulceration. In particular, our findings demonstrate the efficacy of SDX in patients with mixed arterial and venous chronic ulcers of the lower limbs.

The current work investigates a recently introduced unidirectional wave model, applicable in science and engineering to understand complex systems and phenomena. This investigation has two primary aims. First, it employs a novel modified Sardar sub-equation method, not yet explored in the literature, to derive new solutions for the governing model. Second, it analyzes the complex dynamical structure of the governing model using bifurcation, chaos, and sensitivity analyses. To provide a more accurate depiction of the underlying dynamics, they use quantum mechanics to explain the intricate behavior of the system. To illustrate the physical behavior of the obtained solutions, 2D and 3D plots, along with a phase plane analysis, are presented using appropriate parameter values. These results validate the effectiveness of the employed method, providing thorough and consistent solutions with significant computational efficiency. The investigated soliton solutions will be valuable in understanding complex physical structures in various scientific fields, including ferromagnetic dynamics, nonlinear optics, soliton wave theory, and fiber optics. This approach proves highly effective in handling the complexities inherent in engineering and mathematical problems, especially those involving fractional-order systems.

Studies carried out by X-ray and thermal analysis confirmed that acetaminophen (paracetamol), declared by the manufacturers as an Active Pharmaceutical Ingredient (API), was present in all studied medicinal drugs. Positions of diffraction lines (2θ angles) of the studied drugs were consistent with standards for acetaminophen, available in the ICDD PDF database Release 2008. |Δ2θ| values were lower than 0.2°, confirming the authenticity of the studied drugs. Also, the values of interplanar distances dhkl for the examined samples were consistent with those present in the ICDD. Presence of acetaminophen crystalising in the monoclinic system (form I) was confirmed. Various line intensities for API were observed in the obtained diffraction patterns, indicating presence of the preferred orientation of the crystallites in the examined samples. Thermal analysis of the studied substances confirmed the results obtained by X-ray analysis. Drugs containing only acetaminophen as an API have melting point close to that of pure acetaminophen. It was found that presence of other active and auxiliary substances affected the shapes and positions of endothermal peaks significantly. A broadening of endothermal peaks and their shift towards lower temperatures were observed accompanying an increase in the contents of additional substances being “impurities” in relation to the API. The results obtained by a combination of the two methods, X-ray powder diffraction (XRPD) and differential scanning calorimetry/thermogravimetry (DSC/TGA), may be useful in determination of abnormalities which can occur in pharmaceutical preparations, e.g., for distinguishing original drugs and forged products, detection of the presence of a proper polymorphic form or too low content of the active substance in the investigated drug.

The present study focuses on investigating the evolution of phase transformations in the Mg-Ni-Ce system under the influence of mechanical synthesis (MS) and spark plasma sintering (SPS). Magnesium powder mixtures with different nickel and cerium contents (Mg-3%Ni-2%Ce, Mg-7%Ni-3%Ce, and Mg-10%Ni-5%Ce) were mechanically activated along with various grinding parameters. The X-ray phase analysis (XRD) has shown the successive stages of the phase formation in the MS process: from the initial components to the formation of intermetallic compounds of Mg2Ni, Mg12Ni6, and CeMg3. An increase in the intensity of mechanical treatment facilitated the accelerated destruction of the crystal lattice, the generation of defects, and the formation of new phases, as evidenced by the broadening and reduction in the intensity of Mg diffraction peaks. The subsequent SPS stage promoted the completion of phase transformations, structural stabilization, and the formation of a dense, multicomponent microstructure with a uniform distribution of intermetallic compounds. The observed average crystallite sizes ranged from 20 to 70 nm, depending on the processing conditions. The research results demonstrate the possibility of targeted control over the phase composition, opening new opportunities for the development of highly efficient hydrogen-absorbing alloys.