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Objective 　To investigate the predictive value of preoperative neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in surgical site infection (SSI) following radical resection for rectal cancer. Methods 　Retrospective analysis of clinical data was performed about 298 patients undergoing radical resection of rectal cancer in the Chinese PLA General Hospital from January 2015 to February 2018. According to whether SSI occurred 30 days after surgery, patients were divided into SSI group (n=20) and control group (n=278). Gender, age, preoperative neoadjuvant chemoradiation, surgical procedure, T stage, and preoperative neutrophil count, lymphocyte count, platelet count, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), albumin, and hemoglobin level were compared between the two groups. Subgroup analysis was performed in the SSI group according to laparotomy and minimally invasive surgery. Gender, age, preoperative neoadjuvant chemoradiation (CRT), T stage, and preoperative neutrophil

Objective　To monitor the clinical indexes of severe traumatic patients at admission and explore the correlation between death and the combination of Platelet-to-lymphocyte ratio (PLR) and Maximum amplitude (MA) of the thrombus. Methods　The clinical data of 100 severe traumatic patients admitted from May 2015 to September 2016 were investigated. The patients were divided into survivors (n=82) and non-survivors (n=18) based on the prognosis at discharge. The basic clinical data, injure severity score (ISS), acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ) were recorded, and multivariate analysis was used to identify independent predictors by applying binary logistic regression with many factors, including the indexes of blood routine analyses within 1 hour after admission, the coagulation parameters and the parameters of thrombelastogram (TEG). Results 　The mortality of severe traumatic patients was 18.0% in the study. The factors have positive correlation with death, including APACHE Ⅱ (OR=1.497, 95

目的探讨血小板与淋巴细胞比值 (PLR) 、中性粒细胞与淋巴细胞比值 (NLR) 对射频消融术后生存期超过5年的肝细胞癌 (HCC) 患者预后评估价值。方法选取2006年6月-2012年2月于首都医科大学附属北京佑安医院行经肝动脉化疗栓塞术联合射频消融治疗且生存期超过5年的肝细胞癌患者135例。收集所有患者基线实验室及影像检查资料,根据血常规结果计算NLR与PLR。计数资料组间比较采用χ2检验。采用受试者工作特征曲线 (ROC曲线) 确定NLR、PLR临界值,Kaplan-Meier法绘制生存曲线,log-rank检验比较生存率,将log-rank检验分析中具有统计学差异的指标纳入Cox多因素分析。结果根据ROC曲线,确定NLR临界值为2. 08,PLR临界值为96. 82。按照治疗前NLR、PLR临界值分为:低NLR组 (NLR <2. 08,n=60) 与高NLR组 (NLR≥2. 08,n=75) ,低PLR组 (PLR <96. 82,n=78) 与高PLR组 (PLR≥96. 82,n=57) ,结果显示低NLR组与高NLR组患者AFP、巴塞罗那分期差异均有统计学意义 (χ<...

Current research shows that platelet to lymphocyte ratio (PLR) has important prognostic value in renal cell carcinoma, esophageal cancer, gastric cancer, liver cancer and colon cancer. The aim of the study is to evaluate the prognostic value of PLR in non-small cell lung cancer (NSCLC) through meta-analysis. Literature search for PubMed, EMBASE, Web of Science, Medline, Cochrane Library, China National Knowledge Internet (CNKI), China Biomedical Medicine disc (CBMdisc), VIP, Wanfang Database using computer electronic system to study the association between PLR and overall survival (OS) and disease-free survival (DFS). Each eligible study data is extracted and a meta-analysis is performed using the hazard risk (HR) and 95% confidence interval (95%CI) to assess the prognostic value of PLR, the time limit for the search is to build the library until November 2018. We include a total of 15 research literatures involving 5,524 patients for meta-analysis. According to the results of the meta-analysis: The OS of the

Background Explore markers to predict the clinical outcomes of checkpoint inhibitors have high unmet needs. The following study investigates whether hematologic parameter such as systemic immune‐inflammation index (SII), neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte ratio (PLR) is associated with nivolumab efficacy in advanced non‐small‐cell lung cancer (NSCLC). Methods Advanced/metastatic NSCLC patients treated with nivolumab monotherapy for second‐line or further‐line treatment at Jilin Cancer Hospital between March 2016 and July 2018 were enrolled in this retrospective study. The optimal cutoff values of SII, NLR, and PLR for predicting efficacy and prognosis were determined according to receiver operating characteristic (ROC) curve and the areas under the ROC curve. Progression‐free survival (PFS) and overall survival (OS) were calculated and compared using Kaplan‐Meier method and log‐rank test. Prognostic values of each variable were evaluated with univariate and multivariate Cox proportional hazard regression (PHR) analyses. Results A total of 44 patients with advanced NSCLC were included; the median age was 60 (range: 43‐74). The optimal cutoff value of SII/NLR/PLR predicted PFS and OS was 603.5, 3.07, and 144. Low SII, NLR, and PLR were associated with longer PFS (HR for SII = 0.34, 95%CI 0.15‐0.76, P = 0.006; HR for NLR = 0.46, 95%CI 0.22‐0.99, P = 0.048; HR for PLR = 0.39, 95%CI 0.17‐0.94, P = 0.025) and OS (HR for SII = 0.16, 95%CI 0.05‐0.51, P = 0.005; HR for NLR = 0.20, 95%CI 0.06‐0.62, P = 0.002; HR for PLR = 0.20, 95%CI 0.06‐0.73, P = 0.008). NLR ≤ 3.07, PLR ≤ 144, SII ≤ 603.5 were independently associated with longer PFS and OS. Conclusion The SII, NLR, and PLR are promising prognostic predictor for patients with metastatic NSCLC patients.