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29
result(s) for
"polymer-based nanostructures"
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Polymer- and Lipid-Based Nanostructures for Wound Healing with Barrier-Resolved Design
2025
Chronic and hard-to-heal wounds remain burdensome because microbial contamination, dysregulated inflammation, and fragile tissue regeneration slow closure, while passive dressings often injure new tissue during removal. This review synthesizes polymer- and lipid-based nanostructures through a barrier-resolved lens that links composition, architecture, and processing to performance in protease- and salt-rich exudate across topical and transdermal routes. Quantitative trends include effective diameters of approximately 50–300 nm, practical constraints of sterile filtration at 0.2 μm, and therapeutic windows that prioritize contamination control on the first day, support proliferation around day three, and sustain remodeling beyond one week. Mechanistic evidence indicates that interfacial charge and the protein corona govern residence and uptake, lipid bilayers enable dual loading, degradable polymer matrices provide depot-like behavior, and hybrid constructs temper the early burst while improving storage stability.
Journal Article
Polymer-Based Nanostructures for Pancreatic Beta-Cell Imaging and Non-Invasive Treatment of Diabetes
by
Pawlowski, Valérie
,
Abderrahmani, Amar
,
Szunerits, Sabine
in
antidiabetic drug delivery
,
beta cells mass
,
Bioavailability
2023
Diabetes poses major economic, social, and public health challenges in all countries worldwide. Besides cardiovascular disease and microangiopathy, diabetes is a leading cause of foot ulcers and lower limb amputations. With the continued rise of diabetes prevalence, it is expected that the future burden of diabetes complications, early mortality, and disabilities will increase. The diabetes epidemic is partly caused by the current lack of clinical imaging diagnostic tools, the timely monitoring of insulin secretion and insulin-expressing cell mass (beta (β)-cells), and the lack of patients’ adherence to treatment, because some drugs are not tolerated or invasively administrated. In addition to this, there is a lack of efficient topical treatment capable of stopping the progression of disabilities, in particular for treating foot ulcers. In this context, polymer-based nanostructures garnered significant interest due to their tunable physicochemical characteristics, rich diversity, and biocompatibility. This review article emphasizes the last advances and discusses the prospects in the use of polymeric materials as nanocarriers for β-cell imaging and non-invasive drug delivery of insulin and antidiabetic drugs in the management of blood glucose and foot ulcers.
Journal Article
Metal-Organic Frameworks for the Development of Biosensors: A Current Overview
2018
This review focuses on the fabrication of biosensors using metal-organic frameworks (MOFs) as recognition and/or transducer elements. A brief introduction discussing the importance of the development of new biosensor schemes is presented, describing these coordination polymers, their properties, applications, and the main advantages and drawbacks for the final goal. The increasing number of publications regarding the characteristics of these materials and the new micro- and nanofabrication techniques allowing the preparation of more accurate, robust, and sensitive biosensors are also discussed. This work aims to offer a new perspective from the point of view of materials science compared to other reviews focusing on the transduction mechanism or the nature of the analyte. A few examples are discussed depending on the starting materials, the integration of the MOF as a part of the biosensor and, in a deep detail, the fabrication procedure.
Journal Article
Review of Biosensors Based on Plasmonic-Enhanced Processes in the Metallic and Meta-Material-Supported Nanostructures
by
Verma, Sneha
,
Pathak, Akhilesh Kumar
,
Rahman, B. M. Azizur
in
Biosensors
,
Chemical properties
,
Dielectric properties
2024
Surface plasmons, continuous and cumulative electron vibrations confined to metal-dielectric interfaces, play a pivotal role in aggregating optical fields and energies on nanostructures. This confinement exploits the intrinsic subwavelength nature of their spatial profile, significantly enhancing light–matter interactions. Metals, semiconductors, and 2D materials exhibit plasmonic resonances at diverse wavelengths, spanning from ultraviolet (UV) to far infrared, dictated by their unique properties and structures. Surface plasmons offer a platform for various light–matter interaction mechanisms, capitalizing on the orders-of-magnitude enhancement of the electromagnetic field within plasmonic structures. This enhancement has been substantiated through theoretical, computational, and experimental studies. In this comprehensive review, we delve into the plasmon-enhanced processes on metallic and metamaterial-based sensors, considering factors such as geometrical influences, resonating wavelengths, chemical properties, and computational methods. Our exploration extends to practical applications, encompassing localized surface plasmon resonance (LSPR)-based planar waveguides, polymer-based biochip sensors, and LSPR-based fiber sensors. Ultimately, we aim to provide insights and guidelines for the development of next-generation, high-performance plasmonic technological devices.
Journal Article
Advances in Polymer Nanocomposites - Types and Applications
2012
The addition of nanoparticles to polymer composites has led to a new generation of composite materials with enhanced and novel properties. This book reviews the main types of polymer nanocomposites and their applications. Part one reviews types of polymer nanocomposites according to fillers. Processing of carbon nanotube-based nanocomposites, layered double hydroxides (LDHs) and cellulose nanoparticles as functional fillers and reinforcement are discussed, alongside calcium carbonate and metal-polymer nanocomposites. Part two focuses on types of polymer nanocomposites according to matrix polymer, with polyolefin-based, (PVC)-based, nylon-based, (PET)-based and thermoplastic polyurethane (TPU)-based polymer nanocomposites discussed. Soft, gel and biodegradable polymer nanocomposites are also considered. Part three goes on to investigate key applications, including fuel cells, aerospace applications, optical applications, coatings and flame-retardant polymer nanocomposites. With its distinguished editor and international team of expert contributors, this book is an essential guide for professionals and academics involved in all aspects of the design, development and application of polymer nanocomposites.
Polymer-Carbon Nanotube Composites - Preparation, Properties and Applications
2011
Understanding the properties of polymer carbon nanotube (CNT) composites is the key to these materials finding new applications in a wide range of industries, including but not limited to electronics, aerospace and biomedical/bioengineering. This book provides in-depth coverage of the preparation, characterization, properties and applications of these technologically interesting new materials. Part One covers the preparation and processing of composites of thermoplastics with CNTs, with chapters covering in-situ polymerization, melt processing and CNT surface treatment, as well as elastomer and thermoset CNT composites. Part Two concentrates on properties and characterization, including chapters on the quantification of CNT dispersion using microscopy techniques. In Part Three, the applications of polymer/CNT composites are reviewed, with chapters on specific applications such as in fibers and cables, bioengineering applications and conductive polymer CNT composites for sensing. This book is an essential reference for scientists, engineers and designers in high-tech industries and academia with an interest in polymer nanotechnology and nanocomposites.
A Photovoltaic Fiber Design for Smart Textiles
2010
In this paper, the active photovoltaic fibers consisting of nano-layers of polymer-based organic compounds are presented. A flexible solar cell, including a polymer-based anode, two different nano-materials in bulk heterojunction blends as the light absorbing materials, and a semi-transparent cathode to collect the electrons, was formed by coating these materials onto flexible polypropylene (PP) fibers layer by layer, respectively, to produce electricity. Photovoltaic performances of the fibers were analyzed by measuring current versus voltage characteristics under AM1.5 conditions. The maximum value obtained as the short-circuit current density of photovoltaic fibers was 0.27 mA/cm2. The fabrication issues and also possible smart textile applications of these photovoltaic fibers were discussed.
Journal Article