Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
1,213
result(s) for
"recollection"
Sort by:
Repetition, recurrence, returns : how cultural renewal works
\"Repetition is constitutive of human life. Unlike simple recall, repetition is permeated by the past and the present and is oriented toward the future. This book investigates the significance of different forms of repetition in literature, culture, and society through studies of the function and importance of an array of repetitive phenomenon.\" -- Provided by publisher.
BOOK
Preservation of a remote fear memory requires new myelin formation
Experience-dependent myelination is hypothesized to shape neural circuit function and subsequent behavioral output. Using a contextual fear memory task in mice, we demonstrate that fear learning induces oligodendrocyte precursor cells to proliferate and differentiate into myelinating oligodendrocytes in the medial prefrontal cortex. Transgenic animals that cannot form new myelin exhibit deficient remote, but not recent, fear memory recall. Recording population calcium dynamics by fiber photometry, we observe that the neuronal response to conditioned context cues evolves over time in the medial prefrontal cortex, but not in animals that cannot form new myelin. Finally, we demonstrate that pharmacological induction of new myelin formation with clemastine fumarate improves remote memory recall and promotes fear generalization. Thus, bidirectional manipulation of myelin plasticity functionally affects behavior and neurophysiology, which suggests that neural activity during fear learning instructs the formation of new myelin, which in turn supports the consolidation and/or retrieval of remote fear memories.Fear learning induces myelin formation. In the absence of new myelination, remote fear memory and neurophysiology of fear memory circuits are impaired. Conversely, administration of the pro-myelinating drug clemastine enhances remote fear memory.
Journal Article
