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My plastic brain : one woman's yearlong journey to discover if science can improve her mind
\"Using herself as a guinea pig, a science journalist explores 'neuroplasticity' to find out whether she can make meaningful, lasting changes to the way her brain works\"-- Provided by publisher.
Book
Chitosan-Based Biomaterials for Tissue Regeneration
Chitosan is a chitin-derived biopolymer that has shown great potential for tissue regeneration and controlled drug delivery. It has numerous qualities that make it attractive for biomedical applications such as biocompatibility, low toxicity, broad-spectrum antimicrobial activity, and many others. Importantly, chitosan can be fabricated into a variety of structures including nanoparticles, scaffolds, hydrogels, and membranes, which can be tailored to deliver a desirable outcome. Composite chitosan-based biomaterials have been demonstrated to stimulate in vivo regeneration and the repair of various tissues and organs, including but not limited to, bone, cartilage, dental, skin, nerve, cardiac, and other tissues. Specifically, de novo tissue formation, resident stem cell differentiation, and extracellular matrix reconstruction were observed in multiple preclinical models of different tissue injuries upon treatment with chitosan-based formulations. Moreover, chitosan structures have been proven to be efficient carriers for medications, genes, and bioactive compounds since they can maintain the sustained release of these therapeutics. In this review, we discuss the most recently published applications of chitosan-based biomaterials for different tissue and organ regeneration as well as the delivery of various therapeutics.
Journal Article
It's still alive! : magical animals that regrow parts
\"Regenerative animals are survivors. Species with this ability can regrow limbs, skin, organs, and more! Find out how these animals use regeneration to evade predators and stay alive\"-- Provided by publisher.
Book
The lonely giant
\"In the middle of a vast forest lives a giant who spends his days hurling and heaving, smashing and bashing. Over time, the animals flee as their homes vanish, the birdsong dwindles away to silence, and, finally, the forest itself disappears. Now the lonely giant misses the crackling warmth of a fire and the sweet songs of the yellow bird--but will he realize it's up to him to restore what he loves?\"--Provided by publisher.
Book
Use of platelet-rich fibrin in regenerative dentistry: a systematic review
Objectives
Research across many fields of medicine now points towards the clinical advantages of combining regenerative procedures with platelet-rich fibrin (PRF). This systematic review aimed to gather the extensive number of articles published to date on PRF in the dental field to better understand the clinical procedures where PRF may be utilized to enhance tissue/bone formation.
Materials and methods
Manuscripts were searched systematically until May 2016 and separated into the following categories: intrabony and furcation defect regeneration, extraction socket management, sinus lifting procedures, gingival recession treatment, and guided bone regeneration (GBR) including horizontal/vertical bone augmentation procedures. Only human randomized clinical trials were included for assessment.
Results
In total, 35 articles were selected and divided accordingly (kappa = 0.94). Overall, the use of PRF has been most investigated in periodontology for the treatment of periodontal intrabony defects and gingival recessions where the majority of studies have demonstrated favorable results in soft tissue management and repair. Little to no randomized clinical trials were found for extraction socket management although PRF has been shown to significantly decrease by tenfold dry sockets of third molars. Very little to no data was available directly investigating the effects of PRF on new bone formation in GBR, horizontal/vertical bone augmentation procedures, treatment of peri-implantitis, and sinus lifting procedures.
Conclusions
Much investigation now supports the use of PRF for periodontal and soft tissue repair. Despite this, there remains a lack of well-conducted studies demonstrating convincingly the role of PRF during hard tissue bone regeneration. Future human randomized clinical studies evaluating the use of PRF on bone formation thus remain necessary.
Clinical relevance
PRF was shown to improve soft tissue generation and limit dimensional changes post-extraction, with little available data to date supporting its use in GBR.
Journal Article
Correction: Decellularized Allogeneic Heart Valves Demonstrate Self-Regeneration Potential after a Long-Term Preclinical Evaluation
Allogeneic substitutes demonstrated similar gross morpho-anatomic structure to native valves without signs of leaflet fenestration, rupture or degeneration both after decellularization (A–B) and explant at 15 months (C–D). https://doi.org/10.1371/journal.pone.0099593.g001 1. (2014) Decellularized Allogeneic Heart Valves Demonstrate Self-Regeneration Potential after a Long-Term Preclinical Evaluation.
Journal Article