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"sedimentation"
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Correction: Comparative study of impaction and sedimentation in an aerosol chamber using defined fungal spore and bacterial concentrations
[This corrects the article DOI: 10.1371/journal.pone.0187039.].
Journal Article
Effects of B-cell directed therapy on the preclinical stage of rheumatoid arthritis: the PRAIRI study
ObjectivesWe explored the effects of B-cell directed therapy in subjects at risk of developing autoantibodypositive rheumatoid arthritis (RA), who never experienced inflammatory arthritis before, and explored biomarkers predictive of arthritis development.MethodsIndividuals positive for both anti-citrullinated peptide antibodies and rheumatoid factor but without arthritis were included in a randomised, double-blind, placebo-controlled study to receive a single infusion of 1000 mg rituximab or placebo.ResultsEighty-one individuals received treatment and were followed up for a mean of 29.0 (0–54) months, during which 30/81 (37%) individuals developed arthritis. The observed risk of developing arthritis in the placebo-treated group was 40%, which was decreased by 55% (HR 0.45, 95% CI 0.154 to 1.322) in the rituximab-treated group at 12 months. Rituximab treatment caused a delay in arthritis development of 12 months compared with placebo treatment at the point when 25% of the subjects had developed arthritis (p<0.0001). Erythrocyte sedimentation rate and the presence of anti-citrullinated α-enolase peptide 1 at baseline were significant predictors of arthritis development.ConclusionsA single infusion of 1000 mg rituximab significantly delays the development of arthritis in subjects at risk of developing RA, providing evidence for the pathogenetic role of B cells in the earliest, prearthritis stage of autoantibody positive RA.
Journal Article
Pyrite sulfur isotopes reveal glacial–interglacial environmental changes
The sulfur biogeochemical cycle plays a key role in regulating Earth’s surface redox through diverse abiotic and biological reactions that have distinctive stable isotopic fractionations. As such, variations in the sulfur isotopic composition (δ34S) of sedimentary sulfate and sulfide phases over Earth history can be used to infer substantive changes to the Earth’s surface environment, including the rise of atmospheric oxygen. Such inferences assume that individual δ34S records reflect temporal changes in the global sulfur cycle; this assumption may be well grounded for sulfate-bearing minerals but is less well established for pyrite-based records. Here, we investigate alternative controls on the sedimentary sulfur isotopic composition of marine pyrite by examining a 300-m drill core of Mediterranean sediments deposited over the past 500,000 y and spanning the last five glacial–interglacial periods. Because this interval is far shorter than the residence time of marine sulfate, any change in the sulfur isotopic record preserved in pyrite (δ34Spyr) necessarily corresponds to local environmental changes. The stratigraphic variations (>76‰) in the isotopic data reported here are among the largest ever observed in pyrite, and are in phase with glacial–interglacial sea level and temperature changes. In this case, the dominant control appears to be glacial–interglacial variations in sedimentation rates. These results suggest that there exist important but previously overlooked depositional controls on sedimentary sulfur isotope records, especially associated with intervals of substantial sea level change. This work provides an important perspective on the origin of variability in such records and suggests meaningful paleoenvironmental information can be derived from pyrite δ34S records.
Journal Article
Estimating Reservoir Sedimentation Rates and Storage Capacity Losses Using High‐Resolution Sentinel‐2 Satellite and Water Level Data
In nearly all reservoirs, storage capacity is steadily lost due to trapping and accumulation of sediment. Despite critical importance to freshwater supplies, reservoir sedimentation rates are poorly understood due to sparse bathymetry survey data and challenges in modeling sedimentation sequestration. Here, we proposed a novel approach to estimate reservoir sedimentation rates and storage capacity losses using high‐resolution Sentinel‐2 satellites and daily in situ water levels. Validated on eight reservoirs across the central and western United States, the estimated reservoir bathymetry and sedimentation rates have a mean error of 4.08% and 0.05% yr−1, respectively. Estimated storage capacity losses to sediment vary among reservoirs, which overall agrees with the pattern from survey data. We also demonstrated the potential applications of the proposed approach to ungauged reservoirs by combining Sentinel‐2 with sub‐monthly water levels from recent satellite altimeters. Plain Language Summary Reservoir storage capacity is steadily lost due to sediment filling, which threatens freshwater supplies both now and in the future. Yet, lost reservoir storage capacities to sediment are largely unknown. Here, we develop a generic method to estimate capacity losses and reservoir sedimentation rates by leveraging remote sensing techniques. We tested on eight reservoirs across the central and western United States and found capacity losses and sedimentation rates vary across reservoirs. The proposed method offers a promising alternative to evaluate and predict capacity losses in reservoirs nationwide and globally, and thus supports effective water managements and planning for sustainable freshwater supplies in the future. Key Points High‐resolution Sentinel‐2 images and daily in situ water levels were used to estimate reservoir sedimentation rates and capacity losses Estimated reservoir sedimentation rates and storage capacity losses have a mean error of 0.05% yr−1 of full storage capacity Potential applications of this method to ungauged reservoirs are feasible with sub‐monthly level data from recent satellite altimeters
Journal Article
A review of sedimentation rates in freshwater reservoirs: recent changes and causative factors
Sediment deposition in water reservoirs has major implications for storage capacity, reservoir lifetime, and water quality. Changes in rainfall patterns and land use will consequently alter the rate of erosion and therefore have a direct effect on sedimentation rates. This literature review employed a systematic mapping approach to collate and describe evidence of contemporary sedimentation trends for impounded reservoirs and natural lakes with emphasis on studies which analysed impacts on water storage capacity. Fourteen studies determined an overall increase in sedimentation rate, 13 identified a recent decline and another 5 reported mixed results. Interestingly, 83.3% of the articles that studied natural lakes found an increase in recent contemporary sedimentation, while 54.5% of the articles on impounded reservoirs indicated recent declines in sediment deposition. Land use change was the main causative factor responsible for sedimentation rate increase followed by the combined effects of land activities and climate change. Soil and sediment management strategies, implemented in and upstream of some impounded reservoirs, have proved to be effective in mitigating and remediating reservoir sedimentation. From the 147 papers preselected, only 33 contain sufficient sedimentation data to infer recent rate trends with only about 45% of these articles reporting quantities of storage capacity loss caused by sedimentation. Across these 33 studies, assessments of sedimentation and associated storage capacity loss are compromised by the limited spatiotemporal resolution of current measurement methods, reinforcing the requirement to develop new, more robust techniques to monitor sedimentation and storage capacity changes.
Journal Article