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Bloysacknowledged that people are “curious”afterWBDreceived second-round bidsfrom Paramount Skydance and Netflix earlier thisweek,butsaidthe premium cable brand and flagship global streamer is still working on future slates through to 2028 and beyond. [...]whilethose countriesare all set toofferlocaloriginal series(4 Blocks Zero, Banksters, Portobello and a MariaEspoisto-starringdrama about the murder of Melania Rea),Bloysconspicuously didnot mentionthe possibility ofUK originalsinthenear future He did say that “in any market you go into,the ideal situation is to have local originals”,pointing to Italy and Germany as examples. Bloysadmitted the fluctuations between the name of HBO Max – which had the HBO brand, then removed it, then re-added – had created confusion over what a Max original is.

While poly(ethylene glycol) (PEG) hydrogels are generally regarded as biologically inert blank slates, concerns over PEG immunogenicity are growing, and the implications for tissue engineering are unknown. Here, we investigate these implications by immunizing mice against PEG to stimulate anti-PEG antibody production and evaluating bone defect regeneration after treatment with bone morphogenetic protein-2-loaded PEG hydrogels. Quantitative analysis reveals that PEG sensitization increases bone formation compared to naive controls, whereas histological analysis shows that PEG sensitization induces an abnormally porous bone morphology at the defect site, particularly in males. Furthermore, immune cell recruitment is higher in PEG-sensitized mice administered the PEG-based treatment than their naive counterparts. Interestingly, naive controls that were administered a PEG-based treatment also develop anti-PEG antibodies. Sex differences in bone formation and immune cell recruitment are also apparent. Overall, these findings indicate that anti-PEG immune responses can impact tissue engineering efficacy and highlight the need for further investigation. Concerns over the immunogenicity of poly(ethylene glycol) (PEG) are growing, and the implications for tissue engineering are unknown. Here the authors evaluate the impact of anti-PEG antibodies and PEG immunogenicity on the efficacy of a PEG hydrogel-based tissue engineering therapy.

Changing market demand and increasing environmental regulations challenge the refining industry to shift crude slates and reconfigure production processes while reducing emissions. Yet sellers and buyers remain unaware of the carbon footprint of individual marketable networks, and each crude oil has different specifications and is processed in different destination markets. Here we show the global refining carbon intensity at country level and crude level are 13.9–62.1 kg of CO2-equivalent (CO2e) per barrel and 10.1–72.1 kgCO2e per barrel, respectively, with a volume-weighted average of 40.7 kgCO2e per barrel (equivalent to 7.3 gCO2e MJ−1) and energy use of 606 MJ per barrel. We used bottom-up engineering-based refinery modelling on crude oils representing 93% of 2015 global refining throughput. On the basis of projected oil consumption under 2 °C scenarios, the industry could save 56–79 GtCO2e to 2100 by targeting primary emission sources. These results provide guidance on climate-sensitive refining choices and future investment in emissions mitigation technologies.The carbon footprint of oil refining differs depending on crude oil quality and refinery configuration. Analysis of global oil refining in 2015 shows refining carbon intensity at crude, refinery and country levels and highlights potential for emissions reductions.

The term “roofing slate” comprises all natural rocks that can be used for roofing. Some of the characteristics that define their performance as construction materials are water absorption, bending strength, mineral composition, and aesthetics. From a sustainability point of view, roofing slates also have the largest life expectancy and lowest carbon emissions of all covering materials. This work reviews the constructive characteristics of roofing slates, from technical data provided by producers from all over the world. These data, supported by the petrological characterization of several roofing slate samples, are used to propose a general classification for this special type of rock. Thus, roofing slates are sorted in twelve lithotypes, depending of their petrographical characteristics, defined by the color. The resulting classification is named International Roofing Slate Classification (IRSC), formally defined in this paper.

Planes of weakness like schistosity and foliation affect the strength and deformational behaviors of rocks. In this paper, an attempt has been made to study the elastic and strength behavior of slate rocks obtained from foundation of Sardasht dam site in Iran. Wet and dry specimens with different orientation of foliation were evaluated under uniaxial, triaxial, and Brazilian tests. According to the results obtained, slate mechanically pronounced U-shaped anisotropy in uniaxial and triaxial compression tests. In addition, the degree of anisotropy for the slates tested in current study was relatively high, showing the effect of foliation plane on strength and elastic parameters. It was concluded that stiffness of the samples decrease as the angle of anisotropy reaches 30–40°. This change was more pronounced for wet comparing to dry samples. However, the tensile strength obtained during Brazilian tests indicated that there is no apparent relationship between angle of anisotropy and tensile strength. However, increasing the water saturation decreased the tensile strength of the samples. The calculated elastic moduli referring to different anisotropy angles could be valuable for the design of various engineering structures in planar textured rock masses.