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The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight
To understand the health impact of long-duration spaceflight, one identical twin astronaut was monitored before, during, and after a 1-year mission onboard the International Space Station; his twin served as a genetically matched ground control. Longitudinal assessments identified spaceflight-specific changes, including decreased body mass, telomere elongation, genome instability, carotid artery distension and increased intima-media thickness, altered ocular structure, transcriptional and metabolic changes, DNA methylation changes in immune and oxidative stress-related pathways, gastrointestinal microbiota alterations, and some cognitive decline postflight. Although average telomere length, global gene expression, and microbiome changes returned to near preflight levels within 6 months after return to Earth, increased numbers of short telomeres were observed and expression of some genes was still disrupted. These multiomic, molecular, physiological, and behavioral datasets provide a valuable roadmap of the putative health risks for future human spaceflight.
Journal Article
The history of human space flight
\"Highlighting men and women across the globe who have dedicated themselves to pushing the limits of space exploration, this book surveys the programs, technological advancements, medical equipment, and automated systems that have made space travel possible.\"-- Provided by publisher.
Book
Explore space using swarms of tiny satellites
Sand-grain-sized computers, self-healing materials and constellations of craft would reboot our reach, explain Igor Levchenko, Michael Keidar and colleagues.
Sand-grain-sized computers, self-healing materials and constellations of craft would reboot our reach.
Journal Article
Longitudinal metabolomic profiles reveal sex-specific adjustments to long-duration spaceflight and return to Earth
Spaceflight entails a variety of environmental and psychological stressors that may have long-term physiological and genomic consequences. Metabolomics, an approach that investigates the terminal metabolic outputs of complex physiological alterations, considers the dynamic state of the human body and allows the identification and quantification of down-stream metabolites linked to up-stream physiological and genomic regulation by stress. Employing a metabolomics-based approach, this study investigated longitudinal metabolic perturbations of male (
n
= 40) and female (
n
= 11) astronauts on 4–6-month missions to the International Space Station (ISS). Proton nuclear magnetic resonance (
1
H-NMR) spectroscopy followed by univariate, multivariate and machine learning analyses were used on blood serum to examine sex-specific metabolic changes at various time points throughout the astronauts’ missions, and the metabolic effects of long-duration space travel. Space travel resulted in sex-specific changes in energy metabolism, bone mineral and muscle regulation, immunity, as well as macromolecule maintenance and synthesis. Additionally, metabolic signatures suggest differential metabolic responses—especially during the recovery period—with females requiring more time to adjust to return to Earth. These findings provide insight into the perturbations in glucose and amino acid metabolism and macromolecule biosynthesis that result from the stressors of long-duration spaceflight. Metabolomic biomarkers may provide a viable approach to predicting and diagnosing health risks associated with prolonged space travel and other physiological challenges on Earth.
Journal Article
A second space age spanning omics, platforms and medicine across orbits
The recent acceleration of commercial, private and multi-national spaceflight has created an unprecedented level of activity in low Earth orbit, concomitant with the largest-ever number of crewed missions entering space and preparations for exploration-class (lasting longer than one year) missions. Such rapid advancement into space from many new companies, countries and space-related entities has enabled a ‘second space age’. This era is also poised to leverage, for the first time, modern tools and methods of molecular biology and precision medicine, thus enabling precision aerospace medicine for the crews. The applications of these biomedical technologies and algorithms are diverse, and encompass multi-omic, single-cell and spatial biology tools to investigate human and microbial responses to spaceflight. Additionally, they extend to the development of new imaging techniques, real-time cognitive assessments, physiological monitoring and personalized risk profiles tailored for astronauts. Furthermore, these technologies enable advancements in pharmacogenomics, as well as the identification of novel spaceflight biomarkers and the development of corresponding countermeasures. In this Perspective, we highlight some of the recent biomedical research from the National Aeronautics and Space Administration, Japan Aerospace Exploration Agency, European Space Agency and other space agencies, and detail the entrance of the commercial spaceflight sector (including SpaceX, Blue Origin, Axiom and Sierra Space) into aerospace medicine and space biology, the first aerospace medicine biobank, and various upcoming missions that will utilize these tools to ensure a permanent human presence beyond low Earth orbit, venturing out to other planets and moons.
The current ‘second space age’ has enabled multiple studies on the effects of spaceflight on human physiology and health, which are contributing to the development of measures that will be needed to maintain astronaut health in future space missions.
Journal Article
To orbit and back again : how the space shuttle flew in space
\"The Space Shuttle has been the dominant machine in the U.S. space program for thirty years and has generated a great deal of interest among space enthusiasts and engineers. This book enables readers to understand its technical systems in greater depth than they have been able to do so before. The author describes the structures and systems of the Space Shuttle, and then follows a typical mission, explaining how the structures and systems were used in the launch, orbital operations and the return to Earth. Details of how anomalous events were dealt with on individual missions are also provided, as are the recollections of those who built and flew the Shuttle. Many photographs and technical drawings illustrate how the Space Shuttle functions, avoiding the use of complicated technical jargon.\"--Publisher description.
Book
The Planning and Execution of Human Missions to the Moon and Mars
In The Planning and Execution of Human Missions to the Moon and Mars expert contributors from government, academia, and private enterprise explore the myriad challenges that must be overcome in order to conduct deep space travel. From spacecraft operation, mission architecture, and communications to interplanetary supply chains, in-space manufacturing, and beyond, this book is a must-read for everyone from industry professionals to those who dream of an off -world future.
eBook