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Despite increasing interest in the dynamics of functional brain networks, most studies focus on the changing relationships over time between spatially static networks or regions. Here we propose an approach to study dynamic spatial brain networks in human resting state functional magnetic resonance imaging (rsfMRI) data and evaluate the temporal changes in the volumes of these 4D networks. Our results show significant volumetric coupling (i.e., synchronized shrinkage and growth) between networks during the scan, that we refer to as dynamic spatial network connectivity (dSNC). We find that several features of such dynamic spatial brain networks are associated with cognition, with higher dynamic variability in these networks and higher volumetric coupling between network pairs positively associated with cognitive performance. We show that these networks are modulated differently in individuals with schizophrenia versus typical controls, resulting in network growth or shrinkage, as well as altered focus of activity within a network. Schizophrenia also shows lower spatial dynamical variability in several networks, and lower volumetric coupling between pairs of networks, thus upholding the role of dynamic spatial brain networks in cognitive impairment seen in schizophrenia. Our data show evidence for the importance of studying the typically overlooked voxel‐wise changes within and between brain networks. Spatially dynamic brain networks show significant volumetric coupling with synchronized growth and shrinkage, referred to as dynamic spatial network connectivity (dSNC). Dynamic variability in such networks and coupling between network pairs are positively associated with cognitive performance, while showing negative association with schizophrenia, highlighting their possible role in cognitive impairment.

Nearest neighbor (NN) and range (RN) queries are basic query types in spatial databases. In this study, we refer to collections of NN and RN queries as spatial proximity (SP) queries. At peak times, location-based services (LBS) need to quickly process SP queries that arrive simultaneously. Timely processing can be achieved by increasing the number of LBS servers; however, this also increases service costs. Existing solutions evaluate SP queries sequentially; thus, such solutions involve unnecessary distance calculations. This study proposes a unified batch algorithm (UBA) that can effectively process SP queries in dynamic spatial networks. With the proposed UBA, the distance between two points is indicated by the travel time on the shortest path connecting them. The shortest travel time changes frequently depending on traffic conditions. The goal of the proposed UBA is to avoid unnecessary distance calculations for nearby SP queries. Thus, the UBA clusters nearby SP queries and exploits shared distance calculations for query clusters. Extensive evaluations using real-world roadmaps demonstrated the superiority and scalability of UBA compared with state-of-the-art sequential solutions.

With the increasing availability of real-time traffic information, dynamic spatial networks are pervasive nowa- days and path planning in dynamic spatial networks becomes an important issue. In this light, we propose and investigate a novel problem of dynamically monitoring shortest paths in spatial networks （DSPM query）. When a traveler aims to a des- tination, his/her shortest path to the destination may change due to two reasons： 1） the travel costs of some edges have been updated and 2） the traveler deviates from the pre-planned path. Our target is to accelerate the shortest path computing in dynamic spatial networks, and we believe that this study may be useful in many mobile applications, such as route planning and recommendation, car navigation and tracking, and location-based services in general. This problem is challenging due to two reasons： 1） how to maintain and reuse the existing computation results to accelerate the following computations, and 2） how to prune the search space effectively. To overcome these challenges, filter-and-refinement paradigm is adopted. We maintain an expansion tree and define a pair of upper and lower bounds to prune the search space. A series of optimization techniques are developed to accelerate the shortest path computing. The performance of the developed methods is studied in extensive experiments based on real spatial data.

This chapter looks at the problem of representing change and behaviors in graphs. One of the most common goals in analyzing dynamic graphs is to be able to understand how network members and connections change over time or between different scenarios. The chapter examines several methods of visualizing changes between windows of time in the affinity data set, giving a sense of the relative strengths of each technique. In many ways, organic animation is the most obvious technique for portraying change in graphs. One of the most effective strategies for visualizing graph change is to apply layout to the sum of all nodes and edges across the full time span and maintain the layout through time. Transaction graphs go one step deeper and articulate the series of events within each relationship in the graph for the purposes of understanding patterns of behavior.

We use machine learning to perform super-resolution analysis of grossly under-resolved turbulent flow field data to reconstruct the high-resolution flow field. Two machine learning models are developed, namely, the convolutional neural network (CNN) and the hybrid downsampled skip-connection/multi-scale (DSC/MS) models. These machine learning models are applied to a two-dimensional cylinder wake as a preliminary test and show remarkable ability to reconstruct laminar flow from low-resolution flow field data. We further assess the performance of these models for two-dimensional homogeneous turbulence. The CNN and DSC/MS models are found to reconstruct turbulent flows from extremely coarse flow field images with remarkable accuracy. For the turbulent flow problem, the machine-leaning-based super-resolution analysis can greatly enhance the spatial resolution with as little as 50 training snapshot data, holding great potential to reveal subgrid-scale physics of complex turbulent flows. With the growing availability of flow field data from high-fidelity simulations and experiments, the present approach motivates the development of effective super-resolution models for a variety of fluid flows.

Background In 2015, the Zika virus spread from Brazil throughout the Americas, posing an unprecedented challenge to the public health community. During the epidemic, international public health officials lacked reliable predictions of the outbreak’s expected geographic scale and prevalence of cases, and were therefore unable to plan and allocate surveillance resources in a timely and effective manner. Methods In this work, we present a dynamic neural network model to predict the geographic spread of outbreaks in real time. The modeling framework is flexible in three main dimensions (i) selection of the chosen risk indicator, i.e., case counts or incidence rate; (ii) risk classification scheme, which defines the high-risk group based on a relative or absolute threshold; and (iii) prediction forecast window (1 up to 12 weeks). The proposed model can be applied dynamically throughout the course of an outbreak to identify the regions expected to be at greatest risk in the future. Results The model is applied to the recent Zika epidemic in the Americas at a weekly temporal resolution and country spatial resolution, using epidemiological data, passenger air travel volumes, and vector habitat suitability, socioeconomic, and population data for all affected countries and territories in the Americas. The model performance is quantitatively evaluated based on the predictive accuracy of the model. We show that the model can accurately predict the geographic expansion of Zika in the Americas with the overall average accuracy remaining above 85% even for prediction windows of up to 12 weeks. Conclusions Sensitivity analysis illustrated the model performance to be robust across a range of features. Critically, the model performed consistently well at various stages throughout the course of the outbreak, indicating its potential value at any time during an epidemic. The predictive capability was superior for shorter forecast windows and geographically isolated locations that are predominantly connected via air travel. The highly flexible nature of the proposed modeling framework enables policy makers to develop and plan vector control programs and case surveillance strategies which can be tailored to a range of objectives and resource constraints.

State-of-the-art global hydrological models (GHMs) exhibit large uncertainties in hydrological simulations due to the complexity, diversity, and heterogeneity of the land surface and subsurface processes, as well as the scale dependency of these processes and associated parameters. Recent progress in machine learning, fueled by relevant Earth observation data streams, may help overcome these challenges. But machine learning methods are not bound by physical laws, and their interpretability is limited by design. In this study, we exemplify a hybrid approach to global hydrological modeling that exploits the data adaptivity of neural networks for representing uncertain processes within a model structure based on physical principles (e.g., mass conservation) that form the basis of GHMs. This combination of machine learning and physical knowledge can potentially lead to data-driven, yet physically consistent and partially interpretable hybrid models. The hybrid hydrological model (H2M), extended from Kraft et al. (2020), simulates the dynamics of snow, soil moisture, and groundwater storage globally at 1∘ spatial resolution and daily time step. Water fluxes are simulated by an embedded recurrent neural network. We trained the model simultaneously against observational products of terrestrial water storage variations (TWS), grid cell runoff (Q), evapotranspiration (ET), and snow water equivalent (SWE) with a multi-task learning approach. We find that the H2M is capable of reproducing key patterns of global water cycle components, with model performances being at least on par with four state-of-the-art GHMs which provide a necessary benchmark for H2M. The neural-network-learned hydrological responses of evapotranspiration and grid cell runoff to antecedent soil moisture states are qualitatively consistent with our understanding and theory. The simulated contributions of groundwater, soil moisture, and snowpack variability to TWS variations are plausible and within the ranges of traditional GHMs. H2M identifies a somewhat stronger role of soil moisture for TWS variations in transitional and tropical regions compared to GHMs. With the findings and analysis, we conclude that H2M provides a new data-driven perspective on modeling the global hydrological cycle and physical responses with machine-learned parameters that is consistent with and complementary to existing global modeling frameworks. The hybrid modeling approaches have a large potential to better leverage ever-increasing Earth observation data streams to advance our understandings of the Earth system and capabilities to monitor and model it.

Single-molecule localization microscopy (SMLM) can be used to resolve subcellular structures and achieve a tenfold improvement in spatial resolution compared to that obtained by conventional fluorescence microscopy. However, the separation of single-molecule fluorescence events that requires thousands of frames dramatically increases the image acquisition time and phototoxicity, impeding the observation of instantaneous intracellular dynamics. Here we develop a deep-learning based single-frame super-resolution microscopy (SFSRM) method which utilizes a subpixel edge map and a multicomponent optimization strategy to guide the neural network to reconstruct a super-resolution image from a single frame of a diffraction-limited image. Under a tolerable signal density and an affordable signal-to-noise ratio, SFSRM enables high-fidelity live-cell imaging with spatiotemporal resolutions of 30 nm and 10 ms, allowing for prolonged monitoring of subcellular dynamics such as interplays between mitochondria and endoplasmic reticulum, the vesicle transport along microtubules, and the endosome fusion and fission. Moreover, its adaptability to different microscopes and spectra makes it a useful tool for various imaging systems. Multi-frame super-resolution microscopy is hampered by long acquisition times and phototoxicity, which hinder its use for live-cell imaging. Here, authors propose a deep-learning-based single-frame super-resolution approach to image cellular dynamics with high spatiotemporal resolution.

Although informal knowledge networks have often been regarded as a key ingredient behind the success of industrial clusters, the forces that shape their structure and dynamics remain largely unknown. Drawing on recent network dynamic models, we analyze the evolution of business and technical knowledge networks within a toy cluster in Spain. Empirical results suggest that the dynamics of the two networks differ to a large extent. We find that status drives the formation of business knowledge networks, proximity is more crucial for technical knowledge networks, while embeddedness plays an equally important role in the dynamics of both networks.