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Information, democracy, and autocracy : economic transparency and political (in)stability
\"Advocates for economic development often call for greater transparency. But what does transparency really mean? What are its consequences? This breakthrough book demonstrates how information impacts major political phenomena, including mass protest, the survival of dictatorships, democratic stability, as well as economic performance. The book introduces a new measure of a specific facet of transparency: the dissemination of economic data. Analysis shows that democracies make economic data more available than do similarly developed autocracies. Transparency attracts investment and makes democracies more resilient to breakdown. But transparency has a dubious consequence under autocracy: political instability. Mass-unrest becomes more likely, and transparency can facilitate democratic transition - but most often a new despotic regime displaces the old. Autocratic leaders may also turn these threats to their advantage, using the risk of mass-unrest that transparency portends to unify the ruling elite. Policy-makers must recognize the trade-offs transparency entails.\"-- Provided by publisher.
Book
On the stability of de Sitter inflationary solution in the Starobinsky-Bel-Robinson gravity
We will present the way to derive a de Sitter inflationary solution within the so-called Starobinsky-Bel-Robinson gravity. Then, we will show by using the dynamical system method whether the obtained solution is stable or not. According to the stability of the de Sitter inflationary solution, we could judge which phase of our universe, among the two early and late-time phases, is more appropriate for this solution.
Journal Article
Robustness and evolvability in living systems
All living things are remarkably complex, yet their DNA is unstable, undergoing countless random mutations over generations. Despite this instability, most animals do not grow two heads or die, plants continue to thrive, and bacteria continue to divide.Robustness and Evolvability in Living Systemstackles this perplexing paradox. The book explores why genetic changes do not cause organisms to fail catastrophically and how evolution shapes organisms' robustness. Andreas Wagner looks at this problem from the ground up, starting with the alphabet of DNA, the genetic code, RNA, and protein molecules, moving on to genetic networks and embryonic development, and working his way up to whole organisms. He then develops an evolutionary explanation for robustness.
Wagner shows how evolution by natural selection preferentially finds and favors robust solutions to the problems organisms face in surviving and reproducing. Such robustness, he argues, also enhances the potential for future evolutionary innovation. Wagner also argues that robustness has less to do with organisms having plenty of spare parts (the redundancy theory that has been popular) and more to do with the reality that mutations can change organisms in ways that do not substantively affect their fitness.
Unparalleled in its field, this book offers the most detailed analysis available of all facets of robustness within organisms. It will appeal not only to biologists but also to engineers interested in the design of robust systems and to social scientists concerned with robustness in human communities and populations.
eBook
Instability, index theorem, and exponential trichotomy for Linear Hamiltonian PDEs
Consider a general linear Hamiltonian system
eBook
Reflections on slope stability engineering
\"This book contains the detailed reflections of its author who has practised and researched in the field for over a half century. It is written in an informal style that makes it an interesting and thought-provoking practitioner guide to landslides and slope problems and their investigation, analysis, and remediation, considering both natural and man-made slopes and earthworks, and without the need for the usual equations and illustrations. Reflections on Slope Stability Engineering is targeted primarily at practitioners working in the investigations of slope instability and the design and construction of treatments of the problem, especially those early in their careers, but the accessible style also suits students who are developing an interest in the subject and even those engineers with only a casual interest in this branch of geotechnics\"-- Provided by publisher.
BOOK
A Recap of Voltage Stability Indices in the Past Three Decades
Increasing demand for electricity and the modernization of power systems within competitive markets has induced power systems to operate close to their stability limits. Therefore, the continuous monitoring and control of power systems through voltage stability indices is urgently needed. This is the first-ever effort to examine more than 40 voltage stability indices based on their formulation, application, performance, and assessment measures. These indices are sorted based on a logical and chronological order considering the most recent indices to be applied worldwide. However, the generalizability of these indices in terms of multivariable objectives is limited. Despite its limitation, this study systematically reviews available indices in the literature within the past three decades to compile an integrated knowledge base with an up-to-date exposition. This is followed by a comparative analysis in terms of their similarity, functionality, applicability, formulation, merit, demerit, and overall performance. Also, a broad categorization of voltage stability indices is addressed. This study serves as an exhaustive roadmap of the issue and can be counted as a reference for planning and operation in the context of voltage stability for students, researchers, scholars, and practitioners.
Journal Article
The waves of time : long-term change and international relations
This work provides an overview of the whole range of long-term analyses in international relations, in their interdisciplinary context.
Book
Algorithm for optimized mRNA design improves stability and immunogenicity
Messenger RNA (mRNA) vaccines are being used to combat the spread of COVID-19 (refs.
1
–
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), but they still exhibit critical limitations caused by mRNA instability and degradation, which are major obstacles for the storage, distribution and efficacy of the vaccine products
4
. Increasing secondary structure lengthens mRNA half-life, which, together with optimal codons, improves protein expression
5
. Therefore, a principled mRNA design algorithm must optimize both structural stability and codon usage. However, owing to synonymous codons, the mRNA design space is prohibitively large—for example, there are around 2.4 × 10
632
candidate mRNA sequences for the SARS-CoV-2 spike protein. This poses insurmountable computational challenges. Here we provide a simple and unexpected solution using the classical concept of lattice parsing in computational linguistics, where finding the optimal mRNA sequence is analogous to identifying the most likely sentence among similar-sounding alternatives
6
. Our algorithm LinearDesign finds an optimal mRNA design for the spike protein in just 11 minutes, and can concurrently optimize stability and codon usage. LinearDesign substantially improves mRNA half-life and protein expression, and profoundly increases antibody titre by up to 128 times in mice compared to the codon-optimization benchmark on mRNA vaccines for COVID-19 and varicella-zoster virus. This result reveals the great potential of principled mRNA design and enables the exploration of previously unreachable but highly stable and efficient designs. Our work is a timely tool for vaccines and other mRNA-based medicines encoding therapeutic proteins such as monoclonal antibodies and anti-cancer drugs
7
,
8
.
An algorithm based on concepts established in computational linguistics enables rapid principled design of mRNA vaccines optimizing both structural stability and codon usage, resulting in improved half-life, protein expression and immune responses.
Journal Article