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is a low-abundance Gram-negative oral pathobiont that is highly associated with a silent but aggressive orphan disease that results in periodontitis and tooth loss in adolescents of African heritage. For the most part conducts its business by utilizing strategies allowing it to conceal itself below the radar of the host mucosal immune defense system. A great deal of misinformation has been conveyed with respect to biology in health and disease. The purpose of this review is to present misconceptions about and the strategies that it uses to colonize, survive, and evade the host. In the process manages to undermine host mucosal defenses and contribute to disease initiation. This review will present clinical observational, molecular, and interventional studies that illustrate genetic, phenotypic, and biogeographical tactics that have been recently clarified and demonstrate how survives and suppresses host mucosal defenses to take part in disease pathogenesis. At one point in time was considered to be the causative agent of Localized Aggressive Periodontitis. Currently, it is most accurate to look at as a community activist and necessary partner of a pathogenic consortium that suppresses the initial host response so as to encourage overgrowth of its partners. The data for activist role stems from molecular genetic studies complemented by experimental animal investigations that demonstrate how establishes a habitat (housing), nutritional sustenance in that habitat (food), and biogeographical mobilization and/or relocation from its initial habitat (transportation). In this manner can transfer to a protected but vulnerable domain (pocket or sulcus) where its community activism is most useful. 's \"strategy\" includes obtaining housing, food, and transportation at no cost to its partners challenging the economic theory that \"there ain't no such thing as a free lunch.\" This \"strategy\" illustrates how co-evolution can promote survival, on one hand, and overgrowth of community members, on the other, which can result in local host dysbiosis and susceptibility to infection.

Main conclusionThis review is an effort to provide in-depth knowledge of microbe’s interaction and its role in crop microbiome using combination of advanced molecular and OMICS technology to translate this information for the sustenance of agriculture.Increasing population, climate change and exhaustive agricultural practices either influenced nutrient inputs of soil or generating biological and physico-chemical deterioration of the soils and affecting the agricultural productivity and agro-ecosystems. Alarming concerns toward food security and crop production claim for renewed attention in microbe-based farming practices. Microbes are omnipresent (soil, water, and air) and their close association with plants would help to accomplish sustainable agriculture goals. In the last few decades, the search for beneficial microbes in crop production, soil fertilization, disease management, and plant growth promotion is the thirst for eco-friendly agriculture. The crop microbiome opens new paths to utilize beneficial microbes and manage pathogenic microbes through integrated advanced biotechnology. The crop microbiome helps plants acquire nutrients, growth, resilience against phytopathogens, and tolerance to abiotic stresses, such as heat, drought, and salinity. Despite the emergent functionality of the crop microbiome as a complicated constituent of the plant fitness, our understanding of how the functionality of microbiome influenced by numerous factors including genotype of host, climatic conditions, mobilization of minerals, soil composition, nutrient availability, interaction between nexus of microbes, and interactions with other external microbiomes is partially understood. However, the structure, composition, dynamics, and functional contribution of such cultured and uncultured crop microbiome are least explored. The advanced biotechnological approaches are efficient tools for acquiring the information required to investigate the microbiome and extract data to develop high yield producing and resistant variety crops. This knowledge fills the fundamental gap between the theoretical concepts and the operational use of these advanced tools in crop microbiome studies. Here, we review (1) structure and composition of crop microbiome, (2) microbiome-mediated role associated with crops fitness, (3) Molecular and -omics techniques for exploration of crop microbiome, and (4) current approaches and future prospectives of crop microbiome and its exploitation for sustainable agriculture. Recent -omic approaches are influential tool for mapping, monitoring, modeling, and management of crops microbiome. Identification of crop microbiome, using system biology and rhizho-engineering, can help to develop future bioformulations for disease management, reclamation of stressed agro-ecosystems, and improved productivity of crops. Nano-system approaches combined with triggering molecules of crop microbiome can help in designing of nano-biofertilizers and nano-biopesticides. This combination has numerous merits over the traditional bioinoculants. They stimulate various defense mechanisms in plants facing stress conditions; provide bioavailability of nutrients in the soil, helps mitigate stress conditions; and enhance chances of crops establishment.

The nutritional requirements of Drosophila have mostly been studied for development and reproduction, but the minimal requirements for adult male and female flies for lifespan have not been established. Following development on a complete diet, we find substantial sex difference in the basic nutritional requirement of adult flies for full length of life. Relative to females, males require less of each nutrient, and for some nutrients that are essential for development, adult males have no requirement at all for lifespan. The most extreme (and surprising) sex differences were that chronic cholesterol and vitamin deficiencies had no effect on the lifespan of adult males, but they greatly decreased lifespan in females. Female oogenesis rather than chromosomal karyotype and mating status is the key cause of this gender difference in life‐sustaining nutritional requirements. These data are important to the way we understand the mechanisms by which diet modifies lifespan. We found that relative to females, adult males require less of each nutrient for lifespan. The most surprising sex differences was that chronic deprivation of the developmentally essential nutrients cholesterol and vitamins had no effect on the lifespan of adult males, but they greatly decreased lifespan in females. Female oogenesis rather than chromosomal karyotype and mating status is the key cause of this gender difference in life‐sustaining nutritional requirements.

To date, degraded mangrove ecosystem restoration accomplished worldwide primarily aligns towards rehabilitation with monotypic plantations, while ecological restoration principles are rarely followed in these interventions. However, researchers admit that most of these initiatives' success rate is not appreciable often. An integrative framework of ecological restoration for degraded mangroves where site-specific observations could be scientifically rationalized, with co-located reference pristine mangroves as the target ecosystem to achieve is currently distinctively lacking. Through this experimental scale study, we studied the suitability of site-specific strategies to ecologically restore degraded mangrove patches vis-à-vis the conventional mono-species plantations in a highly vulnerable mangrove ecosystem in Indian Sundarbans. This comprehensive restoration framework was trialed in small discrete degraded mangrove patches spanning ~ 65 ha. Site-specific key restoration components applied are statistically validated through RDA analyses and Bayesian t-tests. 25 quantifiable metrics evaluate the restoration success of a ~ 3 ha degraded mangrove patch with Ridgeline distribution, Kolmogorov–Smirnov (K-S) tests, and Mahalanobis Distance (D 2 ) measure to prove the site’s near-equivalence to pristine reference in multiple ecosystem attributes. This restoration intervention irrevocably establishes the greater potential of this framework in the recovery of ecosystem functions and self-sustenance compared to that of predominant monoculture practices for vulnerable mangroves.

Exclusive breastfeeding (EBF) is not a norm in many communities in South Africa despite the World Health Organizations’ recommendations for EBF in the first six months of infant’s life. Thus, South Africa continues to observe suboptimal and poor practices of EBF. The purpose of the study was to explore the experiences of mothers who are HIV-positive and negative on EBF and examine the extent to which initiation and sustenance of EBF is influenced by cultural beliefs, societal norms, and family norms and practices in Mpumalanga Province. Three focus group discussions and twelve in-depth interviews were conducted among thirty mothers who were purposively selected during their visits to the facilities for childcare services. Interviews were audiotaped, transcribed verbatim, and transcripts were analysed through thematic analysis using NVivo version 10. Mothers were aged between 18 and 42 years, most were unemployed and were living in poor sociodemographic backgrounds in extended family households. We found evidence of factors that influence the decision to EBF and mix feed infants among mothers. Traditional and cultural beliefs and norms that exist within their communities informed decisions mothers took to EBF. These beliefs existed alongside mothers’ opinions on breastfeeding (BF) and HIV infection, as well as the fears of harming the baby through HIV infection, leading to early cessation of BF. Mothers were also advised by family members, friends, and even some healthcare workers to use traditional medicines while BF. The association of EBF with sagging breasts and weight loss as well as discomfort with public BF are personal beliefs that influenced initiation and early cessation of EBF. Breastfeeding messages ought to be context specific to improve the knowledge, understanding, acceptance and practice of EBF among HIV-positive and negative mothers. Culturally appropriate counselling messages that address the known cultural practices of the populations affected are essential to changing the beliefs and norms of the communities including extended families of EBF mothers.

This study aims to investigate the relationship between sustaining factors and lean manufacturing implementation. This survey-based study was a cross-sectional study and the samples were drawn by using cluster sampling procedure from medium and large manufacturing companies based on the Federation of Manufacturers Malaysia (FMM) with the final number of 151 respondents. In total, four hypotheses were developed and tested statically using PLS-SEM through SmartPLS software. The result provided evidence that lean culture, lean leadership, and lean knowledge management have a positive relationship on lean manufacturing implementation. However, lean supplier management does not have a positive relationship on lean manufacturing implementation. The survey was responded by middle and top-level management from the discrete manufacturing industries. Although there is growing interest in empirical shreds of evidence in favor of sustaining lean, this study provides a comprehensive view of sustaining factors for lean manufacturing implementation. Hence, this study contributes to expanding the boundary of the existing literature and contributes to the body of knowledge while providing insights to practitioners in tailoring strategies to sustain lean manufacturing implementation and leverage their performance.

Springs are a significant source of high quality and perennial freshwater supply for remote communities and sustain rich biodiversity and ecosystems in the Himalayas. About 60–70% of the Himalayan population directly depends on springs to meet their domestic and livelihood needs. Despite that, decline in approximately 60% of low discharge springs have been reported in the last couple of decades. In addition, nitrates and faecal coliform contamination linked to septic tanks, open defecation, and fertiliser application have been reported. A high degree of urbanization with 500 growing townships and 8–10 large cities has further threatened the sustenance of these vital resources, causing a severe water crisis in the Himalayas. Spring rejuvenation can enhance water access and livelihoods and help achieve several sustainable development goals (SDGs). However, multiple challenges hinder the success of such initiatives. A fundamental limitation is the poor understanding of complex groundwater (spring) systems and their interactions with human societies. This review identified crucial knowledge gaps by synthesizing available knowledge on springs and revival efforts from peer-reviewed journals and reports by practitioners and governing bodies. The review also highlights the limitations of spring revival approaches and recommends future management options. There is a critical lack of comprehensive data as a large research on the Himalayan spring systems results from small-scale spring centric studies focussing primarily on hydrology. In contrast, the impacts of hydrogeology, ecology, socio-economics and developmental activities on springs are less explored. Lack of scientific inputs on the hydrogeological regime and limited support by the state is a barrier to scaling spring rejuvenation programs. Long term monitoring, location-specific mapping of local hydrogeological and socio-economic settings at aquifer scale and collaborations among different stakeholders are essential to facilitate holistic knowledge development on spring systems and successful spring revival. The authors recommend ensuring sustenance by recognizing the value of springs in the mainstream programs and policies and develop appropriate management framework for the management of spring systems.

Abstract Salmonella enterica serovar Typhi (S. Typhi), the causative agent of typhoid in humans, shares a high degree of homology with a closely related serovar, S. Typhimurium. Yet, unlike S. Typhimurium, S. Typhi does not establish infection in mice, the reasons for which are not well understood. Here, we present evidence that the response of mice to infection with S. Typhi is marked by early antibacterial activities. Cell-free peritoneal fluids from S. Typhi but not S. Typhimurium—infected mice inhibited the replication of Salmonella ex vivo. The production of this activity was reduced in the presence of the serine protease inhibitor, phenylmethylsulfonlyl fluoride (PMSF). PMSF also inhibited the generation of antibacterial activity released from in vitro S. Typhi—infected peritoneal macrophages in a cell death—dependent manner. Infection with S. Typhimurium but not S. Typhi was associated with reduction in the mRNA levels of iron-regulating molecules, ferroportin and lipocalin. These results suggest that early induction and sustenance of antibacterial activities may contribute to the nonestablishment of infection with S. Typhi in mice. S. Typhi activates antibacterial responses in mice.

Present study follows a beneficiation and characterization campaign for the alumina-silica rich iron ore prior to sintering. The collected ore had a mineral assay with Fe grade—60.03%, Al 2 O 3 —3.12%, and SiO 2 —7.86%, with 84.35% material of size above 0.5 mm, and a majority of hematite type. The end process being sintering no further size reduction is carried out restricting the further chances of liberation. Considering the high alumina and silica in the ore, a beneficiation treatment needs to be deployed. For which, a suitable beneficiation route is identified depending on the material characteristics, cost, and end-user requirements. A gravity concentration method was recommended due to its economy and suitability for a coarser feed size (− 10 + 0.15 mm). Under gravity separation, a jig-spiral route was levied where jig and spiral were utilized for treating the − 10 + 1 mm and − 1 + 0.15 mm fraction, respectively. Concentrates with a Fe grade of 64.97%, Al 2 O 3 —1.20%, and SiO 2 —1.65% was obtained. The concentrate obtained after beneficiation was then subjected to an in-depth characterization to seek out the occurrences if any have been advanced with respect to the as-received ore characterization. A substantial reduction was observed within the impurity constituent that highlights the efficacy of the followed beneficiation route. This campaign established a low operational expenditure process to reduce the alumina and silica from the iron ore.

Potato (Solanum tuberosum) is an indispensable commodity, mainly cultivated by high-altitude mountain households, that sustains and supports the livelihood of an overwhelming 51% of the Bhutanese population. The popularity of potato cultivation among Bhutanese farmers can be attributed to the crop’s adaptability to a wide range of agroclimatic conditions such as a rainfed crop, high productivity, an assured market, and a reliable source of income for the farming families. We hypothesize that the changing climate would make the livelihood associated with potato cultivation in Bhutan more vulnerable. We tested this hypothesis to identify the sources of vulnerability of smallholder farming households using the Livelihood Vulnerability Index (LVI) and LVI-IPCC (Intergovernmental Panel on Climate Change) approaches in six potato growing districts of Bhutan: Bumthang, Chukha, Gasa, Mongar, Tashigang, and Wangdue. Primary data were generated through a semi structured sample survey of 240 households on the seven major livelihood components of sociodemographic profiles, livelihood strategies, social networks, health, food, water, natural disasters, and climate variability. The results showed that the LVI (range 0.302 to 0.375) and LVI-IPCC (range −0.005 to 0.030) differed significantly (p < 0.001) across the districts. The districts of Tashigang and Mongar were less vulnerable than the other four districts by the LVI approach, whereas Bumthang was also revealed to be less vulnerable using the LVI-IPCC approach. The degree of vulnerability in a district differed according to their level of exposure and adaptive capacity to the climate change impacts of the potato farming household. The results are expected to serve as empirical evidence for designing a future course of actions to mitigate the negative impacts.