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INTRODUCTION We investigated the associations of leptin markers with cognitive function and magnetic resonance imaging (MRI) measures of brain atrophy and vascular injury in healthy middle‐aged adults. METHODS We included 2262 cognitively healthy participants from the Framingham Heart Study with neuropsychological evaluation; of these, 2028 also had available brain MRI. Concentrations of leptin, soluble leptin receptor (sOB‐R), and their ratio (free leptin index [FLI]), indicating leptin bioavailability, were measured using enzyme‐linked immunosorbent assays. Cognitive and MRI measures were derived using standardized protocols. RESULTS Higher sOB‐R was associated with lower fractional anisotropy (FA, β = −0.114 ± 0.02, p < 0.001), and higher free water (FW, β = 0.091 ± 0.022, p < 0.001) and peak‐width skeletonized mean diffusivity (PSMD, β = 0.078 ± 0.021, p < 0.001). Correspondingly, higher FLI was associated with higher FA (β = 0.115 ± 0.027, p < 0.001) and lower FW (β = ‐0.096 ± 0.029, p = 0.001) and PSMD (β = ‐0.085 ± 0.028, p = 0.002). DISCUSSION Higher leptin bioavailability was associated with better white matter (WM) integrity in healthy middle‐aged adults, supporting the putative neuroprotective role of leptin in late‐life dementia risk. Highlights Higher leptin bioavailability was related to better preservation of white matter microstructure. Higher leptin bioavailability during midlife might confer protection against dementia. Potential benefits might be even stronger for individuals with visceral obesity. DTI measures might be sensitive surrogate markers of subclinical neuropathology.

This book lays out the reasons why we should study cognitive development in adulthood, and presents the history, latest data, and results from the Seattle Longitudinal Study (SLS), which now extends to over forty-five years. The SLS is organized around five questions: does intelligence change uniformly throughout adulthood, or are there different life-course-ability patterns? At what age and at what magnitude can decrement in ability be reliably detected? What are the patterns and magnitude of generational differences? What accounts for individual differences in age-related change in adulthood? Can the intellectual decline that increases with age be reversed by educational intervention? Based on work on the SLS, this book presents a conceptual model. The model represents this book's author's view on the factors that influence cognitive development throughout the human lifespan, and provides a rationale for the various influences that have been investigated — genetic factors, early and current family environment, life styles, the experience of chronic disease, and various personality attributes. The data in this volume include the 1998 longitudinal cycle of the SLS. In light of both new data and revised analyses, psychometric and neuropsychological assessments have been linked in long-term data to aid in the early identification of risk for dementia in later life. The book also presents new data and concludes on the impact of personality on cognition. It includes correlation matrices and web-access information for select data sets.

Age trajectories of physiological indices contain important information about aging-related changes in the human organism and therefore may help us understand human longevity. The goal of this study is to investigate whether shapes of such trajectories earlier in life affect the residual life span distribution. We used longitudinal limited access data from seven physiological indices and life spans of respective individuals collected in the Framingham Heart Study (FHS). These include: diastolic blood pressure (DBP), pulse pressure (PP), body mass index (BMI), serum cholesterol (SCH), blood glucose (BG), hematocrit (HC), and pulse rate (PR). We developed a method for assigning individuals to groups of potentially long-lived (PLL) and potentially medium-lived (PML) groups using age trajectories of physiological indices at the age interval between 40 and 60 years. The analysis shows that the longevity of individuals who survived to age of 65 depends on the behavior of the physiological indices between 40 and 60 years of age.

The National Children's Study (NCS) is planned to be the largest long-term study of environmental and genetic effects on children's health ever conducted in the United States. It proposes to examine the effects of environmental influences on the health and development of approximately 100,000 children across the United States, following them from before birth until age 21. By archiving all of the data collected, the NCS is intended to provide a valuable resource for analyses conducted many years into the future.This book evaluates the research plan for the NCS, by assessing the scientific rigor of the study and the extent to which it is being carried out with methods, measures, and collection of data and specimens to maximize the scientific yield of the study.The book concludes that if the NCS is conducted as proposed, the database derived from the study should be valuable for investigating hypotheses described in the research plan as well as additional hypotheses that will evolve. Nevertheless, there are important weaknesses and shortcomings in the research plan that diminish the study's expected value below what it might be.

Why are females rarely antisocial and males antisocial so often? This key question is addressed in a fresh approach to sex differences in the causes, course and consequences of antisocial behaviour. The book presents findings from a landmark investigation of 1,000 males and females studied from ages 3 to 21 years. It shows that young people develop antisocial behaviour for two main reasons. One form of antisocial behaviour is a neurodevelopmental disorder afflicting males, with low prevalence in the population, early childhood onset and subsequent persistence. The other form of antisocial behaviour, afflicting females as well as males, is common and emerges in the context of social relationships. The book offers insights about diagnosis and measurement, the importance of puberty, the problem of partner violence and the nature of intergenerational transmission. It puts forward an agenda for research about both neurodevelopmental and social influences on antisocial behaviour.

The twentieth century saw significant increases in both life expectancy and retirement rates-changes that have had dramatic impacts on nearly every aspect of society and the economy. Forecasting future trends in health and retirement rates, as we must do now, requires investigation of such long-term trends and their causes. To that end, this book draws on new data-an extensive longitudinal survey of Union Army veterans born between 1820 and 1850-to examine the factors that affected health and labor force participation in nineteenth-century America. Contributors consider the impacts of a variety of conditions-including social class, wealth, occupation, family, and community-on the morbidity and mortality of the group. The papers investigate and address a number of special topics, including the influence of previous exposure to infectious disease, migration, and community factors such as lead in water mains. They also analyze the roles of income, health, and social class in retirement decisions, paying particular attention to the social context of disability. Economists and historians who specialize in demography or labor, as well as those who study public health, will welcome the unique contributions offered by this book, which offers a clearer view than ever before of the workings and complexities of life, death, and labor during the nineteenth century.

The Last Years of Long Lives is a unique account of that period of old age which precedes death. Based on 400 complete individual histories and covering a twenty-year period, it looks at the experiences of people over eighty years old in three important areas: disability, family life and health care. Using the life-course approach to research, it reveals rich data about the contributions of formal and informal care and how life expectancy and experiences of disability interact with experiences of care.The reader is invited to conceptualise these phenomena as processes in continuous time - processes that are sometimes long and complex, sometimes short and simple - and learns about the four types of disability career before death. At the same time, the author presents a three-stage model of informal care and examines the main patterns of formal service use.The Last Years of Long Lives presents a new way of looking at old age for students, researchers, practitioners and policy makers and gives a comprehensive picture of what has been called 'the fourth age'.

One of the major changes in the social science research landscape in recent years has been the introduction of computerised panel surveys in Europe and the US which make longitudinal data widely available to graduate students for the first time. Elisabetta Ruspini here provides a concise yet comprehensive introduction to the issues involved in this kind of research. This book: * Defines the concept of longitudinal research * Gives guidance on sources of longitudinal data in Europe and the US and their strengths and weaknesses * Discusses the choices that need to be made in this kind of research - for instance the advantages and disadvantages of certain types of research data and of different types of analysis * Highlights some of the problems involved, e.g. the issue of comparability within longitudinal research

This book discusses the most important techniques available for longitudinal data analysis, from simple techniques such as the paired t-test and summary statistics, to more sophisticated ones such as generalized estimating of equations and mixed model analysis. A distinction is made between longitudinal analysis with continuous, dichotomous and categorical outcome variables. The emphasis of the discussion lies in the interpretation and comparison of the results of the different techniques. The second edition includes new chapters on the role of the time variable and presents new features of longitudinal data analysis. Explanations have been clarified where necessary and several chapters have been completely rewritten. The analysis of data from experimental studies and the problem of missing data in longitudinal studies are discussed. Finally, an extensive overview and comparison of different software packages is provided. This practical guide is essential for non-statisticians and researchers working with longitudinal data from epidemiological and clinical studies.

Though much has been written about twins, very little research has been done into their everyday lives, both postnatal and prenatal. In this fascinating new study Alessandra Piontelli follows the development and behaviour of thirty pairs of twins from their early life in the womb through to their third year of childhood. Drawing on detailed ultrasound observations and work with mothers and families in clinical and natural settings, the text traces the subtle ways in which various types of twins live, behave and interact with their unequally shared and unique pre- and postnatal environments.Piontelli shows how from early on distinctive and personal traits can be seen in the behaviour of each member of a twin couple and how these traits continue and strengthen well beyond birth. The book describes not only the behaviour of the twins, but the impact they have on the lives of their family and carers - what family members say, how they react and how the family changes.Scientifically based, but warmly human in content, this unique longitudinal study offers new insight for professionals working with mothers and families of twins and for researchers in human development across a range of disciplines.