Explore the vast range of titles available.

The aim of our work was to synthetize of a new analogue of abiraterone—thiolated abiraterone (HS-AB) and design a gold surface monolayer, bearing in mind recent advances in tuning monolayer structures and using them as efficient drug delivery systems. Therapeutic self-assembled monolayers (TSAMs) were prepared by chemically attaching HS-AB to gold surfaces. Their properties were studied by voltammetry and atomic force microscopy (AFM). A gold electrode with immobilized thioglycolic acid (HS-GA) was used for comparison. The surface concentration of HS-AB on the gold surface was 0.572 nmol/cm2, determined from the area of the voltammetric reduction peaks (desorption process). The area per one molecule estimated from the voltammetry experiments was 0.291 nmol/cm2. The capacity of thus prepared electrode was also tested. The calculated capacity for the HS-AB modified electrode is 2.90 μF/cm2. The obtained value indicates that the monolayer on the gold electrode is quite well ordered and well-packed. AFM images show the formation of gold nanoparticles as a result of immersing the HS-AB modified gold electrode in an aqueous solution containing 1 mM HAuCl4·3H2O. These structures arise as a result of the interaction between the HS-AB compound adsorbed on the electrode and the AuCl4− ions. The voltammetric experiments also confirm the formation of gold structures with specific catalytic properties in the process of oxygen reduction.

In this investigation, pressure microwave irradiation was used to clarify the activity of 1-(2-hydroxyphenyl)-3-(4-methylphenyl)prop-2-en-1-one (3) towards several active methylene derivatives utilized the pressurized microwave irradiation as green energy resource . Chalcone 3 was allowed to react with ethyl cyanoacetate, acetylacetone, and thioglycolic acid; respectively, at 70 °C with pressure under microwave reaction condition to afford the corresponding 2-hydroxyphenylcyanopyridone, 2-hydroxyphenyl acetylcyclohexanone, and thieno[2,3- c ]chromen-4-one derivatives respectively. Moreover, the reaction of chalcone 3 with hydrogen peroxide with stirring affords the corresponding chromen-4-one derivative. All the synthesized compounds were confirmed through spectral tools such as FT-IR, 1 HNMR, 13 CNMR, and mass spectrum. Furthermore, the synthesized heterocycles were exhibited excellent antioxidant activity and comparable with vitamin C, where the presence of the OH group increases the scavenger radical inhibition. Furthermore, the biological activity of compound 12 was demonstrated through molecular docking stimulation using two proteins, PDBID: 1DH2 and PDBID: 3RP8, which showed that compound 12 possesses greater binding energy and a shorter bond length comparable with ascorbic acid. Also, the compounds were optimized through DFT/B3LYP/6-31G (d,p) basis set and identification of their physical descriptors, whereas the compound 12 was confirmed through X-Ray single structure with Hirsh field analysis of the compound to know the hydrogen electrostatic bond interaction, and correlated with the optimized structure by comparing their bond length, bond angle, FT-IR, and NMR, which gave excellent correlation.

We compared the amount of lignin as determined by the three most traditional methods for lignin measurement in three tissues (sugarcane bagasse, soybean roots and soybean seed coat) contrasting for lignin amount and composition. Although all methods presented high reproducibility, major inconsistencies among them were found. The amount of lignin determined by thioglycolic acid method was severely lower than that provided by the other methods (up to 95%) in all tissues analyzed. Klason method was quite similar to acetyl bromide in tissues containing higher amounts of lignin, but presented lower recovery of lignin in the less lignified tissue. To investigate the causes of the inconsistencies observed, we determined the monomer composition of all plant materials, but found no correlation. We found that the low recovery of lignin presented by the thioglycolic acid method were due losses of lignin in the residues disposed throughout the procedures. The production of furfurals by acetyl bromide method does not explain the differences observed. The acetyl bromide method is the simplest and fastest among the methods evaluated presenting similar or best recovery of lignin in all the tissues assessed.

The mechanism features of colloidal quantum dots (QDs) passivation with thioglycolic acid molecules (TGA) for cases of different luminescent properties is considered using FTIR. This problem is considered based on FTIR spectra analysis for various ionic forms of TGA. Experimental TGA molecules FTIR spectra is interpreted, basing on the data on modeling of TGA vibrational modes, realized in the framework of density functional method (DFT /B3LYP/6-31+G(d)) taking into account the vibrations anharmonicity of every functional group. This approach provides a significant improvement in the agreement between the experimental and calculated data. FTIR spectra of Ag 2 S/TGA QDs with exciton and recombination luminescence are differ from each other and B “freeB” TGA molecules. The ν ( S − H ) TGA peak (2559 cm − 1 ) disappears in FTIR spectra of Ag 2 S/TGA QD samples. This fact indicates the interactions between TGA thiol group and dangling bonds of Ag 2 S nanocrystals. Ag 2 S QDs passivation with TGA molecules leads to emergence ν a s (COO − ) (1584 cm − 1 ) and ν s (COO − ) (1387 cm − 1 ) peaks. It indicates TGA adsorption in ionic form. For Ag 2 S/TGA QDs with exciton luminescence we observed (a) significant low-frequency shift of ν s (COO − ) peak from 1388 cm − 1 to 1359 cm − 1 and high-frequency shift of ν a s (COO − ) peak from 1567 cm − 1 to 1581 cm − 1 ; (b) change in the ratio of intensities of ν a s (COO − ) and ν s (COO − ) vibrations. This feature is caused by the change in the symmetry of TGA molecules due to passivation of Ag 2 S quantum dots.For Ag 2 S/TGA QDs with recombination luminescence, the insignificant high-frequency shift of 7–10 cm − 1 for ν a s (COO − ) at 1567 cm − 1 and low-frequency shift of 3–5 cm − 1 for ν s (COO − ) at 1388 cm − 1 , probably caused by the interaction of thiol with Ag 2 S surface is observed. Using FTIR spectra, it was found that IR luminescence photodegradation is also accompanied by changes in the thioglycolic acid molecules, which capped Ag 2 S QDs. In the case of Ag 2 S QDs with exciton luminescence, the degradation process is non-reversible. It is accompanied by TGA photodegradation with the formation of α -thiol-substituted acyl radical (S-CH 2 -CO • ) TGA.

Methods of synthesis of carbaminyl thioglycolic acid anilides have been studied. All the synthesized compounds were tested for pesticide activity, and substances with defoliating and herbicidal activity were identified among them. Compositions with magnesium chlorate have been developed on their basis to improve its defoliating activity. A comparative assessment of the pesticide activity of the synthesized substances was made; in the result, the active compounds with defoliating properties were found, and environmental impact (ecology) was studied.

Monodispersed Fe 3 O 4 magnetic nanoparticles (MNPs) having size of 7 nm have been prepared from iron oleate and made water dispersible by functionalization for biomedical applications. Three different reactions employing thioglycolic acid, aspartic acid and aminophosphonate were performed on oleic acid coated Fe 3 O 4 . In order to achieve a control on particle size, the pristine nanoparticles were heated in presence of ferric oleate which led to increase in size from 7 to 11 nm. Reaction parameters such as rate of heating, reaction temperature and duration of heating have been studied. Shape of particles was found to change from spherical to cuboid. The cuboid shape in turn enhances magneto-crystalline anisotropy ( K u ). Heating efficacy of these nanoparticles for hyperthermia was also evaluated for different shapes and sizes. We demonstrate heat generation from these MNPs for hyperthermia application under alternating current (AC) magnetic field and optimized heating efficiency by controlling morphology of particles. We have also studied intra-cellular uptake and localization of nanoparticles and cytotoxicity under AC magnetic field in human breast carcinoma cell line.

In this investigation, novel 4-((quinolin-4-yl)amino)-thia-azaspiro[4.4/5]alkan-3-ones were synthesized via interactions between 4-(2-cyclodenehydrazinyl)quinolin-2(1H)-one and thioglycolic acid catalyzed by thioglycolic acid. We prepared a new family of spiro-thiazolidinone derivatives in a one-step reaction with excellent yields (67–79%). The various NMR, mass spectra, and elemental analyses verified the structures of all the newly obtained compounds. The antiproliferative effects of 6a–e, 7a, and 7b against four cancer cells were investigated. The most effective antiproliferative compounds were 6b, 6e, and 7b. Compounds 6b and 7b inhibited EGFR with IC[sub.50] values of 84 and 78 nM, respectively. Additionally, 6b and 7b were the most effective inhibitors of BRAF[sup.V600E] (IC[sub.50] = 108 and 96 nM, respectively) and cancer cell proliferation (GI[sub.50] = 35 and 32 nM against four cancer cell lines, respectively). Finally, the apoptosis assay results revealed that compounds 6b and 7b had dual EGFR/BRAF[sup.V600E] inhibitory properties and showed promising antiproliferative and apoptotic activity.

This study presents an appealing approach to sustainable catalysis using cellulose filter paper as a support for copper-catalyzed reactions. The paper was functionalized with thiol groups through a reaction with thioglycolic acid, which served a dual purpose: partially reducing Cu(II) to Cu(I) and stabilizing active copper species via Cu–S interactions. Spectroscopic analysis confirmed the formation of highly dispersed multi-valent Cu 2 O/CuO on the thiol-functionalized cellulose, resulting in a highly efficient copper catalyst. This catalyst demonstrated excellent performance in the oxidative coupling of various amines to imines, achieving yields of 39–99% within 10–30 min. A key advantage of this system is its reusability; the catalyst maintained remarkable stability and activity over ten reaction cycles with straightforward recovery. This paper-based catalyst offers a promising strategy for eco-friendly and cost-effective synthetic processes, with significant implications for green chemistry and industrial applications.

A number of new symmetrically and asymmetrically 2,3-disubstituted quinoxalines were synthesized through functionalization of 2,3-dichloroquinoxaline (2,3-DCQ) with a variety of sulfur and/or nitrogen nucleophiles. The structures of the obtained compounds were established based on their spectral data and elemental analysis. The antimicrobial activity for the prepared compounds was investigated against four bacterial species and two fungal strains. The symmetrically disubstituted quinoxalines 2, 3, 4, and 5 displayed the most significant antibacterial activity, while compounds 6a, 6b, and the pentacyclic compound 10 showed considerable antifungal activity. Furthermore, compounds 3f, 6b showed broad antimicrobial spectrum against most of the tested strains.

Highly luminescent CdS quantum dots capped with thioglycolic acid (TGA@CdS QDs) were synthesized from cadmium chloride and thiourea as cadmium and sulfur sources via simple hydrothermal method. The room temperature photoluminescence (RTPL) properties of TGA@CdS QDs were investigated. The results indicate that the polarity of the solvent and the surface trap state resulted in the broadness Stokes shift between the maximum absorption wavelength and the emission wavelength of TGA@CdS QDs. The Co 2+ sensing properties of fluorescence determination were investigated using TGA@CdS QDs. The as-synthesized CdS QDs exhibits the excellent selectivity and sensitivity of fluorescence quenching for cobalt ion (Co 2+ ). The limit of detection (LOD) is as low as 0.05 μM which is much lower than maximum limit of cobalt ions in drinking water. The linear response range of Co 2+ was from 0.5 to 80 μM. The sensing system revealed the advantages of low detection limit, excellent selectivity, high sensitivity, convenience and low cost. The color change of CdS QDs shows potential applications in the detection of Co 2+ .