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\"The stars of the latest book by award-winning science writer and mathematician Robyn Arianrhod are unlikely celebrities--vectors and tensors. If you took a high school physics course, the word \"vector\" might remind you of the mathematics needed to determine forces on an amusement park ride, say; or of cross products, a special kind of multiplication using a bespoke table and a right-hand rule. You might also remember the introductory definition of a vector as a quantity that has magnitude and (this is the key) direction. Velocity--for example, 25 miles per hour northwest--is a vector; speed, such as 25 miles per hour, is not. Put another way, a velocity vector in space contains not one number, but three-a measurement of speed along each of three dimensions. It sounds simple, in hindsight--yet, as Arianrhod shows in this intriguing story, the idea of a single symbol expressing several things at once is a sophisticated one, millennia in the making. Vectors are examples of an even more sophisticated idea, the tensor. And it's not just space that vectors and tensors can represent, but information, too. Which means that whenever you use a search engine, say, or AI bot, computer graphics, or a host of other digital applications, vectors and tensors are there somewhere in the software. As for physics, there's much more to it than velocities and simple forces! Arianrhod shows how the discovery of vectors and tensors enabled physicists and mathematicians to think brand new thoughts-such as Maxwell did when he ushered in the wireless electromagnetic age, and Einstein when he predicted the curving of four-dimensional space-time and the existence of gravitational waves. Quantum theory, too, makes fine use of these ideas. In other words, vectors and tensors have been critical not only to the way we see our universe, but also to the invention of Wi-Fi, GPS, micro-technology, and so much else that we take for granted today. In exploring the history and significance of vectors and tensors-and introducing the fascinating people who gave them to us--Arianrhod takes readers on an extraordinary, five-thousand-year journey through the human imagination. A celebration of an idea, Vector shows the genius required to imagine the world in new dimensions-and how a clever mathematical construct can direct the future of discovery\"-- Provided by publisher.

Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation of the 366-megabase Glossina morsitans morsitans genome. Analysis of the genome and the 12,308 predicted protein–encoding genes led to multiple discoveries, including chromosomal integrations of bacterial (Wolbachia) genome sequences, a family of lactation-specific proteins, reduced complement of host pathogen recognition proteins, and reduced olfaction/chemosensory associated genes. These genome data provide a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology.

Vector-borne diseases are mainly transmitted through the bites of infected arthropods. They are a major public health concern as they account for more than 700,000 deaths annually. Among many vector-borne pathogens, the neurotropic viruses have been contributing to the increased number of deaths across the globe due to severe neurological complications. Despite the advancement of vector control strategies, the prevalence and severity of neurotropic viral infections have not been alleviated till date. Anthropogenic activities cause persistent fluctuations in temperature and weather trends. This plays a major part in shaping the fate of transmission dynamics and pathogenesis of such diseases. Changes in climatic factors, such as global warming and delayed withdrawal of monsoon, have had huge impacts on stretching the window of disease transmission worldwide. The abundance, survival, feeding activity, and vectorial competence of the arthropods are expected to increase with rising temperatures. This review aims to discuss how climate change affects ecosystems, thereby influencing vectors and the associated neurotropic viruses. It also highlights the urgent need for the \"One Health\" strategy. It is a concept that recognizes that humans and animals do not exist in isolation and are part of a larger ecosystem where their activity and health are interconnected to one another. This holistic approach is essential in addressing the emerging threats posed by climate change, rising rates of infection, and epidemics across the globe.

Over half the world’s population is at risk for viruses transmitted by Aedes mosquitoes, such as dengue and Zika. The primary vector, Aedes aegypti, thrives in urban environments. Despite decades of effort, cases and geographic range of Aedes-borne viruses (ABVs) continue to expand. Rigorously proven vector control interventions that measure protective efficacy against ABV diseases are limited to Wolbachia in a single trial in Indonesia and do not include any chemical intervention. Spatial repellents, a new option for efficient deployment, are designed to decrease human exposure to ABVs by releasing active ingredients into the air that disrupt mosquito–human contact. A parallel, cluster-randomized controlled trial was conducted in Iquitos, Peru, to quantify the impact of a transfluthrin-based spatial repellent on human ABV infection. From 2,907 households across 26 clusters (13 per arm), 1,578 participants were assessed for seroconversion (primary endpoint) by survival analysis. Incidence of acute disease was calculated among 16,683 participants (secondary endpoint). Adult mosquito collections were conducted to compare Ae. aegypti abundance, blood-fed rate, and parity status through mixed-effect difference-in-difference analyses. The spatial repellent significantly reduced ABV infection by 34.1% (one-sided 95% CI lower limit, 6.9%; onesided P value = 0.0236, z = 1.98). Aedes aegypti abundance and blood-fed rates were significantly reduced by 28.6 (95% CI 24.1%, ∞); z = 29.11) and 12.4% (95% CI 4.2%, ∞); z = 22.43), respectively. Our trial provides conclusive statistical evidence from an appropriately powered, preplanned cluster-randomized controlled clinical trial of the impact of a chemical intervention, in this case a spatial repellent, to reduce the risk of ABV transmission compared to a placebo.

\"Offering a fundamental basis in kernel-based learning theory, this book covers both statistical and algebraic principles. It provides over 30 major theorems for kernel-based supervised and unsupervised learning models. The first of the theorems establishes a condition, arguably necessary and sufficient, for the kernelization of learning models. In addition, several other theorems are devoted to proving mathematical equivalence between seemingly unrelated models. With over 25 closed-form and iterative algorithms, the book provides a step-by-step guide to algorithmic procedures and analysing which factors to consider in tackling a given problem, enabling readers to improve specifically designed learning algorithms, build models for new applications and develop efficient techniques suitable for green machine learning technologies. Numerous real-world examples and over 200 problems, several of which are Matlab-based simulation exercises, make this an essential resource for graduate students and professionals in computer science, electrical and biomedical engineering. Solutions to problems are provided online for instructors\"-- Provided by publisher.

Larval source management (LSM) has a long history of advocacy and successes but is rarely adopted where funds are limited. The World Health Organization (WHO) guidelines on malaria prevention recommend the use of LSM as a supplementary intervention to the core vector control methods (insecticide-treated nets and indoor residual spraying), arguing that its feasibility in many settings can be limited by larval habitats being numerous, transient, and difficult to find or treat. Another key argument is that there is insufficient high-quality evidence for its effectiveness to support wide-scale implementation. However, the stagnation of progress towards malaria elimination demands that we consider additional options to the current emphasis on insecticidal commodities targeting adult mosquitoes inside homes. This letter is the result of a global, crossdisciplinary collaboration comprising: (a) detailed online expert discussions, (b) a narrative review of countries that have eliminated local malaria transmission, and (c) a mathematical modeling exercise using two different approaches. Together, these efforts culminated in seven key recommendations for elevating larval source management as a strategy for controlling malaria and other mosquito-borne diseases in Africa (Box 1 ). LSM encompasses the use of larvicide (a commodity) as well as various environmental sanitation measures. Together, these efforts lead to the long-term reduction of mosquito populations, which benefits the entire community by controlling both disease vector and nuisance mosquitoes. In this paper, we argue that the heavy reliance on large-scale cluster-randomized controlled trials (CRTs) to generate evidence on epidemiological endpoints restricts the recommendation of approaches to only those interventions that can be measured by functional units and deliver relatively uniform impact and, therefore, are more likely to receive financial support for conducting these trials. The explicit impacts of LSM may be better captured by using alternative evaluation approaches, especially high-quality operational data and a recognition of locally distinct outcomes and tailored strategies. LSM contributions are also evidenced by the widespread use of LSM strategies in nearly all countries that have successfully achieved malaria elimination. Two modelling approaches demonstrate that a multifaceted strategy, which incorporates LSM as a central intervention alongside other vector control methods, can effectively mitigate key biological threats such as insecticide resistance and outdoor biting, leading to substantial reductions in malaria cases in representative African settings. This argument is extended to show that the available evidence is sufficient to establish the link between LSM approaches and reduced disease transmission of mosquito-borne illnesses. What is needed now is a significant boost in the financial resources and public health administration structures necessary to train, employ and deploy local-level workforces tasked with suppressing mosquito populations in scientifically driven and ecologically sensitive ways. In conclusion, having WHO guidelines that recognize LSM as a key intervention to be delivered in multiple contextualized forms would open the door to increased flexibility for funding and aid countries in implementing the strategies that they deem appropriate. Financially supporting the scale-up of LSM with high-quality operations monitoring for vector control in combination with other core tools can facilitate better health. The global health community should reconsider how evidence and funding are used to support LSM initiatives. Graphical Abstract

Vector-borne diseases are transmitted by haematophagous arthropods (for example, mosquitoes, ticks and sandflies) to humans and wild and domestic animals, with the largest burden on global public health disproportionately affecting people in tropical and subtropical areas. Because vectors are ectothermic, climate and weather alterations (for example, temperature, rainfall and humidity) can affect their reproduction, survival, geographic distribution and, consequently, ability to transmit pathogens. However, the effects of climate change on vector-borne diseases can be multifaceted and complex, sometimes with ambiguous consequences. In this Review, we discuss the potential effects of climate change, weather and other anthropogenic factors, including land use, human mobility and behaviour, as possible contributors to the redistribution of vectors and spread of vector-borne diseases worldwide.In this Review, de Souza and Weaver discuss the potential effects on vector-borne diseases of climate change, weather and other anthropogenic factors, including land use, human mobility and behaviour, as possible contributors to the redistribution of vectors and spread of vector-borne diseases worldwide.