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Based on the connotation and process of innovation-driven development, we have developed a comprehensive evaluation system containing 20 indicators in five aspects, including innovation factors, innovation subjects, innovation environments, innovation outputs, and development performance, to measure the levels of innovation-driven development in Sichuan province. Selecting 21 cities and prefectures in Sichuan province as research objects, we evaluated and measured the innovation-driven development levels of each city and prefecture using the entropy weight method (EWM). According to the evaluation results, the 21 cities and prefectures were divided into four categories depending on their levels of innovation-driven development: advanced-level, high-level, medium-level, and low-level. The results show that there are obvious spatial differences in terms of innovation-driven development levels among cities and prefectures in Sichuan province. Specifically, Chengdu, Mianyang, Panzhihua, and Deyang cities rank among the top four cities because of their advanced and high levels of innovation-driven development, while other cities and prefectures are at the medium and low levels. We also analyzed the innovation-driven development policies and practices of cities and prefectures in Sichuan province, to provide guidance for implementing innovation-driven development strategies in the cities and prefectures in the future.