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揮發性有機化合物暴露與失智症風險之相關性：回溯性世代研究
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揮發性有機化合物暴露與失智症風險之相關性：回溯性世代研究
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Journal Article
揮發性有機化合物暴露與失智症風險之相關性：回溯性世代研究
2023
Overview
目標：本研究探討不同揮發性有機化合物（volatile organic compounds, VOCs）（包括苯、甲苯、乙苯、間／對－二甲苯）暴露和失智症發生的相關性。方法：本研究以臺灣人體生物資料庫中60歲以上的參與者作為研究對象，並使用土地利用迴歸模型評估揮發性有機化合物、空氣污染物、道路交通噪音及溫度的年平均暴露。我們基於自填問卷的醫師診斷結果及簡易心智量表（Mini-Mental State Examination, MMSE）低於24分來判斷受試者是否為失智症個案，總共參與人數為4,917人。我們使用Cox proportion hazards regression探討揮發性有機化合物與失智症發生的相關性，估計風險比及95%信賴區間，並調整道路交通噪音、空氣污染物（細懸浮微粒［particulate matter with an aerodynamic equivalent diameter ≤ 2.5μm, PM_(2.5)］及二氧化氮[nitrogen dioxide, NO_2]）與年平均高溫，計算校正風險。結果：研究對象的苯、甲苯、乙苯、間／對－二甲苯暴露平均分別為3.91±4.31 μg/m^3、2.50±0.35 μg/m^3、2.04±1.20 μg/m^3及10.27±5.78 μg/m^3，其平均人年數為3.43±0.91年，失智症發生率為1.06%。調整空氣污染物、道路交通噪音及年均高溫後，甲苯對失智症發生的風險為0.67（95%CI: 0.51-0.90），且在不同年齡分組（≦65歲／＞65歲）有顯著的修飾效應（P_(interaction)=0.023）。結論：甲苯在共同暴露中與失智症的發生風險有顯著保護相關，且不同年齡分組顯示存在修飾效應。
