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γ-Butyrolactone-induced coelimycin synthesis inhibits AtrA-dependent actinorhodin overproduction in Streptomyces coelicolor A3(2)
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γ-Butyrolactone-induced coelimycin synthesis inhibits AtrA-dependent actinorhodin overproduction in Streptomyces coelicolor A3(2)
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γ-Butyrolactone-induced coelimycin synthesis inhibits AtrA-dependent actinorhodin overproduction in Streptomyces coelicolor A3(2)
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Journal Article
γ-Butyrolactone-induced coelimycin synthesis inhibits AtrA-dependent actinorhodin overproduction in Streptomyces coelicolor A3(2)
2026
Overview
Bacteria from the genus Streptomyces possess one of the most complex gene regulation machineries in the bacterial kingdom, allowing them to coordinate production of multiple compounds at discrete timing. Navigating through these regulatory networks to unlock the biosynthetic potential is challenging. Expression of silent biosynthetic gene clusters (BGCs) often occurs only under strict culture conditions and, as in the case of coelimycin, can be coordinated via quorum sensing. Here, we have investigated the interplay between coelimycin and actinorhodin production in the model organism Streptomyces coelicolor A3(2). We show that even the products of BGCs can have a regulatory function. The richness of potentially competing biosynthetic pathways may hinder high-yield biosynthesis of the desired product under fermentation conditions. Our results show the importance of designing host organisms with lowered background regulation by γ-butyrolactones for the desired biosynthetic pathway activation.
Publisher
American Society for Microbiology,American Society for Microbiology (ASM)
Subject
/ 4-Butyrolactone - pharmacology
/ Anti-Bacterial Agents - biosynthesis
/ Antibiotic and Secondary Metabolite Production
/ antibiotic biosynthesis regulation
/ Bacterial Proteins - genetics
/ Bacterial Proteins - metabolism
/ Biotechnology and Synthetic Biology
/ Gene Expression Regulation, Bacterial
/ Genetics and Molecular Biology
/ Microbial Physiology and Genetics
/ Streptomyces coelicolor - drug effects
/ Streptomyces coelicolor - genetics
