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Effect of immune-related intratumoral microbiota and host gene expression on cancer prognosis
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Effect of immune-related intratumoral microbiota and host gene expression on cancer prognosis
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Journal Article
Effect of immune-related intratumoral microbiota and host gene expression on cancer prognosis
2025
Overview
The intratumoral microbiota is a vital part of the tumor microenvironment, yet its interplay with host gene expression and immune regulation remains unclear. Based on a machine learning framework for the interaction analysis of intratumoral microbiota and host genes, as well as the construction of the Immune and Prognosis-Related Microbial Score, our findings suggest that intratumoral microbiota may influence gene expression by affecting host pathways, especially immune-related pathways. Moreover, immune-related intratumoral microbiota are significantly associated with patient survival and TME immunity and may influence prognosis by affecting immune cells, pathways, or gene expression, offering new perspectives and potential biomarkers for predicting personalized patient prognosis in the future.
Publisher
American Society for Microbiology,American Society for Microbiology (ASM)
Subject
/ Gene Expression Regulation, Neoplastic
/ Host-Microbiome Interactions
/ Humans
/ Immune System Modulation by Microbiota
/ immunity
/ Lymphocytes, Tumor-Infiltrating - immunology
/ Microbiome and Disease Susceptibility
/ Microbiome in Disease Prevention
/ Microbiome-Based Diagnostics
/ survival mediation association
/ TCGA
