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SP-CHAP, an endolysin with enhanced activity against biofilm pneumococci and nasopharyngeal colonization
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SP-CHAP, an endolysin with enhanced activity against biofilm pneumococci and nasopharyngeal colonization
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Journal Article
SP-CHAP, an endolysin with enhanced activity against biofilm pneumococci and nasopharyngeal colonization
2024
Overview
Considering the high rates of pneumococcal resistance reported for several antibiotics, alternatives are urgently needed. In the present study, we report a Streptococcus pneumoniae -targeting endolysin with even greater activity than Cpl-1, the most characterized pneumococcal endolysin to date. We have employed a combination of biochemical and microbiological assays to assess the stability and lytic potential of SP-CHAP and demonstrate its efficacy on pneumococcal biofilms in vitro and in an in vivo mouse model of colonization. Our findings highlight the therapeutic potential of SP-CHAP as an antibiotic alternative to treat Streptococcus pneumoniae infections.
