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A protein disulfide isomerase coordinates redox homeostasis and ER calcium regulation for optimal lytic cycle progression in Toxoplasma gondii
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A protein disulfide isomerase coordinates redox homeostasis and ER calcium regulation for optimal lytic cycle progression in Toxoplasma gondii
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Journal Article
A protein disulfide isomerase coordinates redox homeostasis and ER calcium regulation for optimal lytic cycle progression in Toxoplasma gondii
2026
Overview
The lytic cycle of Toxoplasma gondii is critical for parasite dissemination and disease progression in the host. Calcium signaling plays a crucial role in driving these processes; however, the molecules that control calcium storage and release remain poorly understood. The endoplasmic reticulum, likely the largest calcium reservoir in T. gondii , has been understudied in the context of calcium signaling. Here, we uncover a direct link between ER redox regulation and calcium homeostasis, showing that ER redox activity can influence calcium signaling events that govern microneme protein maturation and secretion, parasite invasion, and replication. Our findings indicate that redox-dependent calcium regulation in the ER contributes to control of the parasite lytic cycle and reveals a previously unrecognized mechanism that may influence parasite virulence.
Publisher
American Society for Microbiology,American Society for Microbiology (ASM)
Subject
/ Clinical Microbiology and Infectious Diseases
/ Endoplasmic Reticulum - metabolism
/ Microbial Pathogenesis and Immunology
/ Protein Disulfide-Isomerases - genetics
/ Protein Disulfide-Isomerases - metabolism
/ Protozoan Proteins - genetics
/ Protozoan Proteins - metabolism
/ SERCA
/ Toxoplasma - growth & development
/ Zoonoses and Vector-Borne Diseases
/ Zoonotic and Vector-Borne Diseases
/ Zoonotic Parasitic Infections
