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mGem: Population genomics of Staphylococcus aureus bacteremia and the impact of the COVID-19 pandemic
by
Sánchez-Osuna, Miquel
, Pich, Oscar Q.
, Gasch, Oriol
, Andam, Cheryl P.
, Wang, Rebecca
, Martin, Isabella W.
, Buiatte, Ana Beatriz Garcez
in
Anti-Bacterial Agents - pharmacology
/ Anti-Bacterial Agents - therapeutic use
/ Antimicrobial Resistance
/ Bacteremia
/ Bacteremia - epidemiology
/ Bacteremia - microbiology
/ Bacterial Infections
/ Bacterial Pathogenesis
/ Bacterial Taxonomy
/ Bacteriology
/ Clinical Microbiology and Infectious Diseases
/ COVID-19 - epidemiology
/ Drug Resistance, Bacterial - genetics
/ Drug Resistant Pathogens
/ Emerging Resistant Pathogens
/ Genome, Bacterial
/ Genomics
/ Genomics and Proteomics
/ Healthcare-Associated Infections
/ Humans
/ Methicillin-Resistant Staphylococcus Aureus (Mrsa)
/ Microbial Pathogenesis and Immunology
/ Pandemics
/ Perspective
/ population genomics
/ Public Health Microbiology
/ SARS-CoV-2
/ Spain - epidemiology
/ Special Series: mGems
/ Staphylococcal Infections
/ Staphylococcal Infections - epidemiology
/ Staphylococcal Infections - microbiology
/ Staphylococcus
/ Staphylococcus aureus
/ Staphylococcus aureus - classification
/ Staphylococcus aureus - drug effects
/ Staphylococcus aureus - genetics
/ Staphylococcus aureus - isolation & purification
/ Staphylococcus aureus - pathogenicity
/ Staphylococcus Aureus Pathogenesis
/ Systemic Infections
/ Virulence Factors - genetics
2026
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mGem: Population genomics of Staphylococcus aureus bacteremia and the impact of the COVID-19 pandemic
by
Sánchez-Osuna, Miquel
, Pich, Oscar Q.
, Gasch, Oriol
, Andam, Cheryl P.
, Wang, Rebecca
, Martin, Isabella W.
, Buiatte, Ana Beatriz Garcez
in
Anti-Bacterial Agents - pharmacology
/ Anti-Bacterial Agents - therapeutic use
/ Antimicrobial Resistance
/ Bacteremia
/ Bacteremia - epidemiology
/ Bacteremia - microbiology
/ Bacterial Infections
/ Bacterial Pathogenesis
/ Bacterial Taxonomy
/ Bacteriology
/ Clinical Microbiology and Infectious Diseases
/ COVID-19 - epidemiology
/ Drug Resistance, Bacterial - genetics
/ Drug Resistant Pathogens
/ Emerging Resistant Pathogens
/ Genome, Bacterial
/ Genomics
/ Genomics and Proteomics
/ Healthcare-Associated Infections
/ Humans
/ Methicillin-Resistant Staphylococcus Aureus (Mrsa)
/ Microbial Pathogenesis and Immunology
/ Pandemics
/ Perspective
/ population genomics
/ Public Health Microbiology
/ SARS-CoV-2
/ Spain - epidemiology
/ Special Series: mGems
/ Staphylococcal Infections
/ Staphylococcal Infections - epidemiology
/ Staphylococcal Infections - microbiology
/ Staphylococcus
/ Staphylococcus aureus
/ Staphylococcus aureus - classification
/ Staphylococcus aureus - drug effects
/ Staphylococcus aureus - genetics
/ Staphylococcus aureus - isolation & purification
/ Staphylococcus aureus - pathogenicity
/ Staphylococcus Aureus Pathogenesis
/ Systemic Infections
/ Virulence Factors - genetics
2026
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mGem: Population genomics of Staphylococcus aureus bacteremia and the impact of the COVID-19 pandemic
by
Sánchez-Osuna, Miquel
, Pich, Oscar Q.
, Gasch, Oriol
, Andam, Cheryl P.
, Wang, Rebecca
, Martin, Isabella W.
, Buiatte, Ana Beatriz Garcez
in
Anti-Bacterial Agents - pharmacology
/ Anti-Bacterial Agents - therapeutic use
/ Antimicrobial Resistance
/ Bacteremia
/ Bacteremia - epidemiology
/ Bacteremia - microbiology
/ Bacterial Infections
/ Bacterial Pathogenesis
/ Bacterial Taxonomy
/ Bacteriology
/ Clinical Microbiology and Infectious Diseases
/ COVID-19 - epidemiology
/ Drug Resistance, Bacterial - genetics
/ Drug Resistant Pathogens
/ Emerging Resistant Pathogens
/ Genome, Bacterial
/ Genomics
/ Genomics and Proteomics
/ Healthcare-Associated Infections
/ Humans
/ Methicillin-Resistant Staphylococcus Aureus (Mrsa)
/ Microbial Pathogenesis and Immunology
/ Pandemics
/ Perspective
/ population genomics
/ Public Health Microbiology
/ SARS-CoV-2
/ Spain - epidemiology
/ Special Series: mGems
/ Staphylococcal Infections
/ Staphylococcal Infections - epidemiology
/ Staphylococcal Infections - microbiology
/ Staphylococcus
/ Staphylococcus aureus
/ Staphylococcus aureus - classification
/ Staphylococcus aureus - drug effects
/ Staphylococcus aureus - genetics
/ Staphylococcus aureus - isolation & purification
/ Staphylococcus aureus - pathogenicity
/ Staphylococcus Aureus Pathogenesis
/ Systemic Infections
/ Virulence Factors - genetics
2026
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mGem: Population genomics of Staphylococcus aureus bacteremia and the impact of the COVID-19 pandemic
Journal Article
mGem: Population genomics of Staphylococcus aureus bacteremia and the impact of the COVID-19 pandemic
2026
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Overview
The pressure of the coronavirus disease 2019 (COVID-19) pandemic on global healthcare systems and societies was unprecedented in the modern era. Social restrictions, containment measures, and disruptions in antimicrobial prescriptions and consumption during the pandemic have been reported to alter the epidemiology of bacterial diseases, although these effects likely differed markedly between locations. Here, we compare the clinical, clonal distribution, and genomic features of
bloodstream isolates before, during, and after COVID-19 in two hospitals on different continents: Parc Taulí University Hospital (Spain) and Dartmouth-Hitchcock Medical Center (USA). We hypothesize that pandemic-related environmental perturbations, such as those due to infection control practices and antimicrobial exposure, may have contributed to shifts in the diversity of circulating bacterial lineages and genomic elements. Our findings revealed changes in the distribution of low-frequency clones, antimicrobial resistance genes, and virulence factors, potentially reflecting changes in selective pressures in clinical environments.
Publisher
American Society for Microbiology,American Society for Microbiology (ASM)
Subject
Anti-Bacterial Agents - pharmacology
/ Anti-Bacterial Agents - therapeutic use
/ Clinical Microbiology and Infectious Diseases
/ Drug Resistance, Bacterial - genetics
/ Emerging Resistant Pathogens
/ Genomics
/ Healthcare-Associated Infections
/ Humans
/ Methicillin-Resistant Staphylococcus Aureus (Mrsa)
/ Microbial Pathogenesis and Immunology
/ Staphylococcal Infections - epidemiology
/ Staphylococcal Infections - microbiology
/ Staphylococcus aureus - classification
/ Staphylococcus aureus - drug effects
/ Staphylococcus aureus - genetics
/ Staphylococcus aureus - isolation & purification
/ Staphylococcus aureus - pathogenicity
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