Journal Article

The benefits of a novel chicken-based oral nutritional supplement for older adults: A double-blind randomized controlled trial

Napaporn Pengsorn, Somboon Intalapaporn, Dujpratana Pisalsarakij, Weerasak Muangpaisan, Titima Wongviriyawong, Narumon Densupsoontorn, Chalobol Chalermsri, Angkana Jongsawadipatana, Wichai Chatthanawaree, Suthipol Udompunturak, Patumporn Suraarunsumrit, Prasert Assantachai, Pipop Jirapinyo

2020

Overview

Background and Objectives: A considerable proportion of older adults are lactose intolerant. The aim of this study was to investigate the clinical safety, efficacy, and tolerability of a chicken-based oral nutritional supplement (ONS). Methods and Study Design: Double-blind randomized controlled trial. Subjects in the intervention group received chicken-based ONS, and those in the control group received a similarly flavored oral fluid placebo. All subjects were followed-up every two months for a total of 6 months. Results: Thirty-eight older adults aged >/= 70 years were recruited. The mean age and BMI were 81.5+/-5.6 years and 19.6 +/- 2.5 kg/m2. At the end of this trial, there was no statistically significant change in sarcopenia-related variables in the intervention group. However, the higher-level physical activity (PA) group within the intervention group had a significantly improved usual gait speed (UGS) compared to the lower-level PA group (p=0.04). The adjusted mean differences in UGS between the high and low level PA groups in the intervention and placebo groups were 0.149 m/sec and 0.083 m/sec, respectively. Significant difference was observed for changes in two bone markers between the intervention and placebo groups. Conclusions: The chicken-based ONS evaluated in this study was well-tolerated. No improvement of sarcopenia-related components was shown by the study ONS. Up to nearly an 80% increase in adjusted mean difference in UGS between the high and low level PA groups was observed in the nutritional intervention group compared to the zero-protein calorie placebo group. Significant improvement in age-related bone resorption was the earliest advantage of taking our ONS.

• Publisher: HEC Press
• Subject: Body mass index / Chronic illnesses / Clinical trials / Dietary supplements / Double-blind studies / Evaluation / Exercise for older people / Fractures / Gait / Geriatrics / Hospitals / Lactose / Lactose in the body / Milk / Nutrition / Old age / Older people / Sarcopenia