Asset Details
Do you wish to reserve the book?
Reduction of the HIV-1 reservoir in T cells from people with HIV-1 on suppressive antiretroviral therapy using expanded natural killer cells
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Reduction of the HIV-1 reservoir in T cells from people with HIV-1 on suppressive antiretroviral therapy using expanded natural killer cells
Do you wish to request the book?
Reduction of the HIV-1 reservoir in T cells from people with HIV-1 on suppressive antiretroviral therapy using expanded natural killer cells
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Reduction of the HIV-1 reservoir in T cells from people with HIV-1 on suppressive antiretroviral therapy using expanded natural killer cells
2026
Overview
Antiretroviral therapy (ART) lowers HIV levels in the blood to nearly undetectable amounts, but stopping therapy almost always leads to HIV rebounding in the bloodstream. DNA and RNA tests show that most people living with HIV (PLWH) on ART retain long-lasting HIV reservoirs that remain hidden from the immune system when no HIV is being produced. Eradicating HIV might look like “drug-free remission,” where HIV reservoirs are kept under control by the immune system even if ART is stopped indefinitely. Current strategies for this potential eradication include using HIV latency-reversing agents (LRAs), ex vivo expansion of natural killer (NK) cells, and improving the ability to kill infected cells with broadly neutralizing antibodies against HIV. Here, we demonstrate that NK cells from PLWH can be expanded outside the body into “eNK” cells that specifically attack HIV-infected cells without harming uninfected ones, significantly reducing HIV reservoirs in vitro after LRA treatment.
Publisher
American Society for Microbiology,American Society for Microbiology (ASM)
Subject
/ Anti-Retroviral Agents - therapeutic use
/ Antibodies, Neutralizing - immunology
/ Antibody-Dependent Cell Cytotoxicity
/ Antibody-dependent cell-mediated cytotoxicity
/ Antigens
/ CD4-Positive T-Lymphocytes - immunology
/ CD4-Positive T-Lymphocytes - virology
/ Cells
/ Clinical Microbiology and Infectious Diseases
/ HIV
/ HIV Infections - drug therapy
/ Human immunodeficiency virus
/ Human Immunodeficiency Virus (Hiv)
/ Humans
/ Killer Cells, Natural - immunology
/ Kinases
/ Latency
/ Ligands
/ Microbial Pathogenesis and Immunology
/ mRNA
/ NK cells
/ Virology
