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Interferon-inducible guanylate-binding protein 5 inhibits replication of multiple viruses by binding to the oligosaccharyltransferase complex and inhibiting glycoprotein maturation
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Interferon-inducible guanylate-binding protein 5 inhibits replication of multiple viruses by binding to the oligosaccharyltransferase complex and inhibiting glycoprotein maturation
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Journal Article
Interferon-inducible guanylate-binding protein 5 inhibits replication of multiple viruses by binding to the oligosaccharyltransferase complex and inhibiting glycoprotein maturation
2025
Overview
Viral infection induces production of type I interferons and expression of interferon-stimulated genes (ISGs) that play key roles in inhibiting viral infection. We found that the interferon-stimulated gene GBP5 is induced by SARS-CoV-2 infection in vitro and in vivo . GBP5 inhibits N-glycosylation of key proteins in multiple viruses, including SARS-CoV-2. Importantly, pharmacological inhibition of oligosaccharyltransferase (OST) complex blocks host cell infection by SARS-CoV-2, variants of concern, HIV-1, and IAV, indicating future translational application of our findings.
Publisher
American Society for Microbiology,American Society for Microbiology (ASM)
Subject
/ COVID-19
/ GBP5
/ Glycosylation - drug effects
/ GTP-Binding Proteins - genetics
/ GTP-Binding Proteins - metabolism
/ Hexosyltransferases - genetics
/ Hexosyltransferases - metabolism
/ HIV
/ Human immunodeficiency virus
/ Humans
/ Membrane Proteins - metabolism
/ Microbial Pathogenesis and Immunology
/ oligosaccharyltransferase (OST) complex
/ Proteins
/ Severe acute respiratory syndrome coronavirus 2
/ Spike Glycoprotein, Coronavirus - genetics
/ Spike Glycoprotein, Coronavirus - metabolism
/ Virions
/ Virology
/ Virus Replication - drug effects
/ Viruses
