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Targeting the lung innate pathways during tuberculosis can improve vaccine-induced protection via Th17 responses in diversity outbred mice
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Targeting the lung innate pathways during tuberculosis can improve vaccine-induced protection via Th17 responses in diversity outbred mice
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Journal Article
Targeting the lung innate pathways during tuberculosis can improve vaccine-induced protection via Th17 responses in diversity outbred mice
2026
Overview
Bacille Calmette Guerin (BCG) vaccination in genetically diverse outbred (DO) mice provides significant protection against Mycobacterium tuberculosis ( Mtb) challenge. This protection induced pathways associated with transforming growth factor B (TGF-β) receptor complex, genes associated with lung repair, and Toll-like receptor (TLR)-10 pathway. The enhanced protection observed in BCG-vaccinated mice correlated with improved formation of B-cell follicles and IL-17-producing CD4 + T-cell responses. CD4 + T-cell responses mediated the enhanced protection in the lungs of DO mice vaccinated with BCG + adjuvant, as depletion of CD4 + T-cell responses reversed the enhanced protection. The DO mouse model of tuberculosis vaccination is a highly relevant model to probe mechanisms of vaccine-induced protection and provide novel insights into lung pathways that mediate protection. The study also found that genes associated with lung repair, including TGF-β receptor complex pathways, were induced in BCG-vaccinated Mtb -infected DO mouse lungs. The study suggests that the activation of lung innate pathways in BCG vaccination through the use of mucosal Amph CpG delivery, CD40L activation, and IL-10 neutralization could significantly enhance protection upon Mtb challenge.
Publisher
American Society for Microbiology,American Society for Microbiology (ASM)
Subject
/ Animals
/ Antigens
/ Bacillus Calmette-Guerin vaccine
/ BCG
/ BCG Vaccine - administration & dosage
/ Clinical Microbiology and Infectious Diseases
/ Female
/ Lungs
/ Mice
/ Microbial Pathogenesis and Immunology
/ Microbial Physiology and Genetics
/ Mycobacterium tuberculosis - immunology
/ Pathogen Biology and Host Interaction
/ Transforming growth factor-b
/ Tuberculosis - prevention & control
/ Tuberculosis Vaccines - administration & dosage
/ Tuberculosis Vaccines - immunology
/ Tuberculosis, Pulmonary - immunology
/ Tuberculosis, Pulmonary - prevention & control
/ Vaccines
