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Degradation of ribosomal RNA during Plasmodium falciparum gametocytogenesis

by Grünebast, Janne , Watson, Kaylee , Kanatani, Sachie , Pascini, Tales Vicari , Olson, Sophie , Dumetz, Franck , Dunning Hotopp, Julie C. , Singhal, Ritwik , Bromley, Robin , Llinás, Manuel , Serre, David , Tripathi, Abhai , Sinnis, Photini

in Animal Infection Models / Animals / Antimalarial Agents / Antimicrobial Resistance / Antiparasitic Therapy / Central Nervous System Infections / Cerebral Malaria / Clinical Microbiology and Infectious Diseases / Degradation / Disease transmission / Drug Resistant Malaria / Environmental conditions / Erythrocytes - parasitology / Exocrine glands / Gametocytes / Gametogenesis / Genes / Host Cell Invasion / Host-Pathogen Interactions / Life Cycle Stages / Life cycles / Life sciences / Lymphatic Filariasis / Malaria / Malaria Pathogenesis / Malarial Pigment (Hemozoin) / Merozoite Surface Proteins / Microbial Pathogenesis and Immunology / Mosquitoes / Mouse Parasitemia Models / Parasites / Parasitic Cell Invasion / Parasitic Pathogenesis / Parasitic-Host Interactions / Parasitology / Plasmodium Biology / Plasmodium falciparum / Plasmodium falciparum - genetics / Plasmodium falciparum - growth & development / Plasmodium falciparum - metabolism / Protozoa / Reagents / Research Article / Ribosomes / RNA polymerase / RNA Stability / RNA, Protozoan - genetics / RNA, Protozoan - metabolism / RNA, Ribosomal - genetics / RNA, Ribosomal - metabolism / rRNA / rRNA switch / Salivary gland / Salivary Glands - parasitology / Sporozoites / Sporozoites - growth & development / Sporozoites - metabolism / translational repression / Tuberculous Musculoskeletal Infections / Vector-Parasite Interactions

2025

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Degradation of ribosomal RNA during Plasmodium falciparum gametocytogenesis

2025

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Degradation of ribosomal RNA during Plasmodium falciparum gametocytogenesis

2025

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Journal Article

Degradation of ribosomal RNA during Plasmodium falciparum gametocytogenesis

Grünebast, Janne,

Watson, Kaylee,

Kanatani, Sachie,

Pascini, Tales Vicari,

Olson, Sophie,

Dumetz, Franck,

Dunning Hotopp, Julie C.,

Singhal, Ritwik,

Bromley, Robin,

Llinás, Manuel,

Serre, David,

Tripathi, Abhai,

Sinnis, Photini

2025

Overview

Our study uses Oxford Nanopore direct RNA sequencing of tightly synchronized blood-stage Plasmodium falciparum parasites to investigate the expression of ribosomal RNAs during asexual and sexual development. P. falciparum utilizes distinct types of rRNA during its development. However, due to the challenges of differentiating these highly similar molecules, their regulation and the mechanism underlying the switch between rRNA types remain unclear. We observe significant rRNA degradation in mature gametocytes, leading us to propose that this potentially leads to a reduced number of functional ribosomes when parasites become quiescent and translation is repressed.

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Publisher

American Society for Microbiology,American Society for Microbiology (ASM)

Subject

Animal Infection Models

/ Animals

/ Antimalarial Agents

/ Antimicrobial Resistance

/ Antiparasitic Therapy

/ Central Nervous System Infections

/ Cerebral Malaria