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ENO2 regulates CD4 + T cell pyroptosis via mitochondrial ROS to drive immunological non-response in HIV infection
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ENO2 regulates CD4 + T cell pyroptosis via mitochondrial ROS to drive immunological non-response in HIV infection
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Journal Article
ENO2 regulates CD4 + T cell pyroptosis via mitochondrial ROS to drive immunological non-response in HIV infection
2025
Overview
The decrease in CD4 + T cell count is an important cause of poor immune reconstitution in HIV-infected patients. In this study, we analyzed the pyroptosis of T cells in HIV-infected patients with poor immune reestablishment and demonstrated how ENO2, a key enzyme in the glycolytic pathway, affects pyroptosis through mitochondrial ROS. Our results clarified the role of ENO2 in regulating CD4 + T cell pyroptosis in INRs and discussed its possible mechanism. This provides a new target for improving immune reconstitution and intervention in HIV infection.
Publisher
American Society for Microbiology,American Society for Microbiology (ASM)
Subject
Acquired immune deficiency syndrome
/ AIDS
/ CD4-Positive T-Lymphocytes - immunology
/ CD4-Positive T-Lymphocytes - metabolism
/ Cell Death Mechanisms (Apoptosis, Necrosis, Pyroptosis)
/ Clinical Microbiology and Infectious Diseases
/ ENO2
/ HIV
/ HIV Infections - drug therapy
/ Human immunodeficiency virus
/ Human Immunodeficiency Virus (HIV)
/ Humans
/ Lipids
/ Microbial Pathogenesis and Immunology
/ Phosphopyruvate Hydratase - genetics
/ Phosphopyruvate Hydratase - metabolism
/ Reactive Oxygen Species - metabolism
/ Virology
