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Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides
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Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides
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Journal Article
Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides
2019
Overview
Theories about the origin of life require chemical pathways that allow formation of life’s key building blocks under prebiotically plausible conditions. Complex molecules like RNA must have originated from small molecules whose reactivity was guided by physico-chemical processes. RNA is constructed from purine and pyrimidine nucleosides, both of which are required for accurate information transfer, and thus Darwinian evolution. Separate pathways to purines and pyrimidines have been reported, but their concurrent syntheses remain a challenge. We report the synthesis of the pyrimidine nucleosides from small molecules and ribose, driven solely by wet-dry cycles. In the presence of phosphate-containing minerals, 5′-mono- and diphosphates also form selectively in one-pot reactions. The pathway is compatible with purine synthesis, allowing the concurrent formation of all Watson-Crick bases.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Minerals
/ Purine Nucleosides - chemical synthesis
/ Purine Nucleosides - chemistry
/ Purine Nucleotides - chemical synthesis
/ Purines
/ Pyrimidine Nucleosides - chemical synthesis
/ Pyrimidine Nucleosides - chemistry
/ Pyrimidine Nucleotides - chemical synthesis
/ Ribonucleotides - chemical synthesis
/ Ribose
/ RNA
