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The DnaJK chaperone of Bacillus subtilis post-transcriptionally regulates gene expression through the YlxR(RnpM)/RNase P complex
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The DnaJK chaperone of Bacillus subtilis post-transcriptionally regulates gene expression through the YlxR(RnpM)/RNase P complex
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Journal Article
The DnaJK chaperone of Bacillus subtilis post-transcriptionally regulates gene expression through the YlxR(RnpM)/RNase P complex
2025
Overview
Bacillus subtilis lacking the DnaJK chaperone has not been reported to exhibit a distinct phenotype. However, our study revealed proline-dependent growth in a minimal medium in the dnaJ ::Tn strain. Inhibition of spoIVCA expression in this strain was identified as a probable cause of the sporulation deficiency in previous and current studies using a single cell-level analysis. We also observed posttranscriptional regulation of proBA by the DnaJK and YlxR(RnpM)/RNase P complex. LacZ analyses of proB::lacZ in different backgrounds suggested that the above regulation ultimately functions in mRNA metabolism. In DnaJK-deficient cells, the nascent peptide may be misfolded, and if DnaJK chaperone activity is lost, such a signal may be transferred to RNase P. Therefore, proBA mRNA may be degraded in an RNase P-dependent manner if the misfolding of the polypeptide translated from this mRNA is detected. This system is useful for reducing the biological costs of futile mRNA elongation.
Publisher
American Society for Microbiology
Subject
/ Bacillus subtilis - enzymology
/ Bacillus subtilis - genetics
/ Bacillus subtilis - metabolism
/ Bacterial Proteins - genetics
/ Bacterial Proteins - metabolism
/ DnaJK
/ E coli
/ Gene Expression Regulation, Bacterial
/ Glucose
/ Heat
/ Molecular Chaperones - genetics
/ Molecular Chaperones - metabolism
/ Peptides
/ Proteins
/ RNA Processing, Post-Transcriptional
/ RNase P
