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The iron-regulated small regulatory RNA IsrR modulates expression of genes utilized for dioxygen metabolism and heme synthesis in Staphylococcus aureus
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The iron-regulated small regulatory RNA IsrR modulates expression of genes utilized for dioxygen metabolism and heme synthesis in Staphylococcus aureus
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Journal Article
The iron-regulated small regulatory RNA IsrR modulates expression of genes utilized for dioxygen metabolism and heme synthesis in Staphylococcus aureus
2025
Overview
Staphylococcus aureus causes numerous and varied infections in mammals, making it a significant public health burden and concern. The prevalence of S. aureus infections is due to its robust repertoire of virulence factors and its ability to adapt to host microenvironments. Elucidation of the metabolic processes and pathways that promote adaptation to host-promoted stressors provides information about host-pathogen interactions. It could also aid the development of new antimicrobials or unveil treatment and prevention strategies. One common stress bacteria encounter within the mammalian hosts is limited access to iron. In response to iron scarcity, S. aureus expresses the regulatory sRNA IsrR. Here, we identified mRNAs that associate with IsrR. We verified that IsrR targets mRNAs that code for proteins involved in aerobic respiration, the metabolism of reactive oxygen species, and heme synthesis. This work provides significant insight into how S. aureus responds to host-mediated iron starvation.
Publisher
American Society for Microbiology,American Society for Microbiology (ASM)
Subject
Adherent-Invasive E. coli Pathogenesis
/ Bacterial Proteins - genetics
/ Bacterial Proteins - metabolism
/ Biochemistry, Molecular Biology
/ Enzymes
/ Fur
/ Gene Expression Regulation, Bacterial
/ Genes
/ Genomics
/ Heme
/ Host Iron Withholding (Nutritional Immunity)
/ Iron
/ IsrR
/ Microbial Pathogenesis and Immunology
/ Microbial Physiology and Genetics
/ Microbiology and Parasitology
/ Proteins
/ RNA, Small Untranslated - genetics
/ RNA, Small Untranslated - metabolism
/ Staphylococcal Infections - microbiology
/ Staphylococcus aureus - genetics
/ Staphylococcus aureus - metabolism
/ Staphylococcus aureus Infection Models
/ tsr25
