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SNARE PROTEIN STRUCTURE AND FUNCTION
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Journal Article
SNARE PROTEIN STRUCTURE AND FUNCTION
2003
Overview
The SNARE superfamily has become, since its discovery approximately a decade
ago, the most intensively studied element of the protein machinery involved in
intracellular trafficking. Intracellular membrane fusion in eukaryotes requires
SNARE (soluble
N
-ethylmaleimide-sensitive-factor attachment protein
receptor) proteins that form complexes bridging the two membranes. Although
common themes have emerged from structural and functional studies of SNAREs and
other components of the eukaryotic membrane fusion machinery, there is still
much to learn about how the assembly and activity of this machinery is
choreographed in living cells.
Publisher
Annual Reviews,Annual Reviews, Inc
