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REGULATION OF MAP KINASE SIGNALING MODULES BY SCAFFOLD PROTEINS IN MAMMALS
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Journal Article
REGULATION OF MAP KINASE SIGNALING MODULES BY SCAFFOLD PROTEINS IN MAMMALS
2003
Overview
The mitogen-activated protein kinase (MAPK) group of serine/threonine
protein kinases mediates the response of cells to many extracellular stimuli
such as cytokines and growth factors. These protein kinases include the
extracellular signal-regulated protein kinases (ERK) and two stress-activated
protein kinases (SAPK), the c-Jun N-terminal kinases (JNK), and the p38 MAPK.
The enzymes are evolutionarily conserved and are activated by a common
mechanism that involves a protein kinase cascade. Scaffold proteins have been
proposed to interact with MAPK pathway components to create a functional
signaling module and to control the specificity of signal transduction. Here we
critically evaluate the evidence that supports a physiologically relevant role
of MAPK scaffold proteins in mammals.
Publisher
Annual Reviews,Annual Reviews, Inc
Subject
Adaptor Proteins, Signal Transducing
/ Animals
/ Carrier Proteins - metabolism
/ Contractile Proteins - metabolism
/ Dual-Specificity Phosphatases
/ Filamins
/ Humans
/ MAP Kinase Kinase Kinases - metabolism
/ MAP Kinase Signaling System - physiology
/ Microfilament Proteins - metabolism
