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CRISPR-Cas9 high-throughput screening to study drug resistance in Leishmania infantum
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CRISPR-Cas9 high-throughput screening to study drug resistance in Leishmania infantum
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Journal Article
CRISPR-Cas9 high-throughput screening to study drug resistance in Leishmania infantum
2024
Overview
Leishmaniasis, a global health threat, lacks adequate treatment options and drug resistance exacerbates the challenge. This study introduces a CRISPR-Cas9 screening approach in Leishmania infantum , unraveling mechanisms of drug resistance at a genome-wide scale. Our screen was applied against two main antileishmanial drugs, and guides were enriched upon drug selection. These guides targeted known and new targets, hence validating the use of this screen against Leishmania . This strategy provides a powerful tool to expedite drug discovery as well as potential therapeutic targets against this neglected tropical disease.
Publisher
American Society for Microbiology
Subject
/ Amphotericin B - pharmacology
/ Antiprotozoal Agents - pharmacology
/ Cloning
/ CRISPR
/ Genes
/ Genomes
/ High-Throughput Screening Assays - methods
/ Kinases
/ Leishmania infantum - drug effects
/ Leishmania infantum - genetics
/ Phosphorylcholine - analogs & derivatives
/ Phosphorylcholine - pharmacology
/ RNA, Guide, CRISPR-Cas Systems - genetics
/ Toxicity
