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PRRSV GP5 inhibits the antivirus effects of chaperone-mediated autophagy by targeting LAMP2A
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PRRSV GP5 inhibits the antivirus effects of chaperone-mediated autophagy by targeting LAMP2A
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Journal Article
PRRSV GP5 inhibits the antivirus effects of chaperone-mediated autophagy by targeting LAMP2A
2024
Overview
Viruses have evolved sophisticated mechanisms to manipulate autophagy to evade degradation and immune responses. Porcine reproductive and respiratory syndrome virus (PRRSV) is a typical immunosuppressive virus that causes enormous economic losses in the swine industry. However, the mechanism by which PRRSV manipulates autophagy to defend against host antiviral effects remains unclear. In this study, we found that PRRSV GP5 interacts with LAMP2A and disrupts the formation of the GFAP-LAMP2A complex, thus inhibiting the activity of CMA and subsequently enhancing the inhibitory effect of the NSP11-mediated IFN-I signaling pathway, ultimately facilitating PRRSV replication. Our study revealed a novel mechanism by which PRRSV escapes host antiviral effects through CMA, providing a potential host target, LAMP2A, for developing antiviral drugs and contributing to understanding the escape mechanism of immunosuppressive viruses.
Publisher
American Society for Microbiology
Subject
/ Animals
/ Chaperone-Mediated Autophagy - genetics
/ Cloning
/ CMA
/ Genomes
/ GFAP
/ Glial fibrillary acidic protein
/ GP5
/ Humans
/ Kinases
/ LAMP2A
/ Lysosomal-Associated Membrane Protein 2 - genetics
/ Lysosomal-Associated Membrane Protein 2 - metabolism
/ Porcine Reproductive and Respiratory Syndrome - immunology
/ Porcine Reproductive and Respiratory Syndrome - metabolism
/ Porcine Reproductive and Respiratory Syndrome - virology
/ Porcine respiratory and reproductive syndrome virus - physiology
/ Proteins
/ PRRSV
/ Swine
/ Viruses
