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Genomic and epidemiological evidence for the emergence of a L. infantum/L. donovani hybrid with unusual epidemiology in northern Italy
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Genomic and epidemiological evidence for the emergence of a L. infantum/L. donovani hybrid with unusual epidemiology in northern Italy
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Genomic and epidemiological evidence for the emergence of a L. infantum/L. donovani hybrid with unusual epidemiology in northern Italy
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Journal Article
Genomic and epidemiological evidence for the emergence of a L. infantum/L. donovani hybrid with unusual epidemiology in northern Italy
2024
Overview
This study closes important knowledge gaps with respect to
Leishmania (L.) infantum
genetic heterogeneity in a given endemic country, as exemplified here for Italy, and reveals genetic hybridization as a main cause for re-emerging human leishmaniasis in northern Italy. The observed high diversity of
Leishmania
parasites on the Italian peninsula suggests different geographical origins, with genomic adaptation to various ecologies affecting both pathogenicity and transmission potential. This is documented by the discovery of a putative
L. infantum
/
L. donovani
hybrid strain, which has been shown to preferentially infect humans but not dogs. Our results provide important information to health authorities, which need to consider the public health risk represented by the introduction of new
Leishmania
species into EU countries due to population displacement or travel from countries where exotic/allochthonous parasite species are endemic.
Publisher
American Society for Microbiology
Subject
/ Dogs
/ Genetics and Molecular Biology
/ Genomics
/ Humans
/ Hybrids
/ Leishmania donovani - classification
/ Leishmania donovani - genetics
/ Leishmania donovani - isolation & purification
/ Leishmania infantum - classification
/ Leishmania infantum - genetics
/ Leishmania infantum - isolation & purification
/ Leishmaniasis, Visceral - epidemiology
/ Leishmaniasis, Visceral - parasitology
/ Microsatellite Repeats - genetics
/ Polymorphism, Single Nucleotide
/ Protozoa
