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Antibodies with specificity to glycan motifs that decorate OMV cargo proteins
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Journal Article
Antibodies with specificity to glycan motifs that decorate OMV cargo proteins
2025
Overview
O-glycosylation of cell surface proteins by bacteria is known to play a role in various functions including colonization and immune evasion. This study highlights the identification of IgM antibodies that specifically recognize O-glycosylated proteins that are selectively carried on outer membrane vesicles (OMVs). The findings suggest a potential host evasion mechanism and open new avenues for using OMVs in vaccine development and targeting O-glycans with antibodies as a therapeutic strategy against the subgingival pathobiont P. gingivalis .
Publisher
American Society for Microbiology
Subject
/ Animals
/ Antibodies, Bacterial - immunology
/ Antigens
/ Antisera
/ Bacteria
/ Bacterial Outer Membrane Proteins - immunology
/ Cells
/ Humans
/ Immunoglobulin M - immunology
/ Mutants
/ OMV
/ PG1881
/ Polysaccharides - immunology
/ Porphyromonas gingivalis - genetics
/ Porphyromonas gingivalis - immunology
/ Proteins
/ Vaccines
