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Genomic Analysis of the BMP Family in Glioblastomas
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Genomic Analysis of the BMP Family in Glioblastomas
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Journal Article
Genomic Analysis of the BMP Family in Glioblastomas
2015
Overview
Glioblastoma multiforme (GBM) is a grade IV glioma with a median survival of 15 months. Recently, bone morphogenetic protein (BMP) signaling has been shown to promote survival in xenograft murine models. To gain a better understanding of the role of BMP signaling in human GBMs, we examined the genomic alterations of 90 genes associated with BMP signaling in GBM patient samples. We completed this analysis using publically available datasets compiled through Te Cancer Genome Atlas and the Glioma Molecular Diagnostic Initiative. Here we show how mRNA expression is altered in GBM samples and how that is associated with patient survival, highlighting both known and novel associations between BMP signaling and GBM biology.
Publisher
Libertas Academica,SAGE Publishing,Sage Publications Ltd. (UK),Sage Publications Ltd
