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Journal Article
RETROTRANSPOSONS PROVIDE AN EVOLUTIONARILY ROBUST NON-TELOMERASE MECHANISM TO MAINTAIN TELOMERES
2003
Overview
Telomere molecular biology is far more complex than originally thought.
Understanding biological systems is aided by study of evolutionary variants,
and
Drosophila
telomeres are remarkable variants.
Drosophila
lack
telomerase and the arrays of simple repeats generated by telomerase in almost
all other organisms; instead,
Drosophila
telomeres are long tandem
arrays of two non-LTR retrotransposons,
HeT-A
and
TART
. These are
the first transposable elements found to have a bona fide role in cell
structure, revealing an unexpected link between telomeres and what is generally
considered to be parasitic DNA. In addition to providing insight into the
cellular functions performed by telomeres, analysis of
HeT-A
and
TART
is providing insight into the evolution of chromosomes,
retrotransposons, and retroviruses. Recent studies show that retrotransposon
telomeres constitute a robust system for maintaining chromosome ends. These
telomeres are now known to predate the separation of extant
Drosophila
species, allowing ample time for elements and hosts to coevolve interesting
mechanisms.
Publisher
Annual Reviews,Annual Reviews, Inc
Subject
