Paper

Flexible, Scalable, High Channel Count Stereo-Electrode for Recording in the Human Brain

Russman, Samantha M, Lee, Keundong, Lee, Jihwan, Tonsfeldt, Karen J, Richardson, Mark, Pezaris, John, Baohan, Amy, Yun Goo Ro, Halgren, Eric, Cleary, Daniel R, Yang, Jimmy C, Kfir, Yoav, Williams, Ziv M, Cash, Sydney S, Fried, Shelley, Tchoe, Youngbin, Paulk, Angelique C, Bourhis, Andrew M, Raslan, Ahmed, Dayeh, Shadi A, Vatsyayan, Ritwik

2023

Overview

Over the past decade, stereotactically placed electrodes have become the gold standard for deep brain recording and stimulation for a wide variety of neurological and psychiatric diseases. Current electrodes, however, are limited in their spatial resolution and ability to record from small populations of neurons, let alone individual neurons. Here, we report on a novel, reconfigurable, monolithically integrated human-grade flexible depth electrode capable of recording from up to 128 channels and able to record at a depth of 10 cm in brain tissue. This thin, stylet-guided depth electrode is capable of recording local field potentials and single unit neuronal activity (action potentials), validated across species. This device represents a major new advance in manufacturing and design approaches which extends the capabilities of a mainstay technology in clinical neurology.Competing Interest StatementThe authors declare the following competing interests: KL, YGR, and SAD and the University of California San Diego filed a patent application for the manufacture of the novel depth electrodes. YT, AMR, and SAD have competing interests not related to this work including equity in Precision Neurotek Inc. and SAD in FeelTheTouch LLC. SAD was a paid consultant to MaXentric Technologies. AMR has an equity and is a cofounder of CerebroAI. AMR received consulting fees from Abbott Inc and Biotronik Inc. The MGH Translational Research Center has clinical research support agreements with Neuralink, Paradromics, and Synchron, for which SSC provide consultative input. The other authors declare that they have no competing interests.Footnotes* Figure 2 had an update.

• Publisher: Cold Spring Harbor Laboratory Press,Cold Spring Harbor Laboratory
• Subject: Brain research / Electrodes / Mental disorders / Neuroscience / Patent applications / Spatial discrimination