Journal Article

IDDF2018-ABS-0234 An analysis of trend, clinico-pathological features and treatment received by multi-ethnic patients with colorectal cancer at a single tertiary care centre in malaysia: a review of 2 decades

Aslan Abdullah, Nik Muhd, Ismail, Fuad, Osman, Syazarina Sharis, Ngiu, Chai Soon, Yaacob, Nur Yazmin, Rehir, Rasyidah, Raja Ali, Raja Affendi, Mohd Azman, Zairul Azwan, Yahaya, Azyani, Mazlan, Luqman, Wong, Zhiqin, Sagap, Ismail, Rose, Isa, Leong, Gee Huey, Naidu, Jeevinesh

2018

Overview

BackgroundThe incidence of colorectal cancer (CRC) is increasing steadily in Asia Pacific region including Malaysia. The collaborative data collection system enables CRC registration to document details of patients with CRC. This study aim to analyse the trend, clinico-pathological features along with treatment modalities received by CRC patients at our centre from 1997–2017.MethodsA Total of 1000 CRC cases were analysed from the hospital medical record system.ResultsThe median age at diagnosis was 63+11.97 years. Majority of patients diagnosed between 50 to 69 years old (57.9%) and 60.5% were males. The trend of CRC among the young patients revealed; Age group 20–39 years at 5.1%, and age group 40–49 years at 10.8%. There was an increment of 14.3% CRC cases in the second decade of analysis. Chinese patients were highest at 52.9%, followed by Malays at 42.3% and Indians at 3.1%. However, for young patients (<50 years old), Malays predominate at 55.3%, and for elderly (>70 years old), Chinese predominate at 59.9%. Most CRC cases were in the rectum (34.1%) with the majority of adenocarcinoma (83.3%) of well-differentiated cells (44.4%). For patients with Duke A:65.4% had surgery alone and 15.4% had surgery, chemotherapy and radiotherapy. For patients with Duke B (34.1%) and C (39.2%): 40.9% had surgery alone, 26.6% had surgery and chemotherapy and 15.1% had surgery and chemo-radiotherapy. For patients with Duke D; 33.3% had palliative surgery along and 9.1% had surgery and chemo-radiotherapy. Anterior resections were most frequently performed at 38%.ConclusionsIn Malaysia, most CRC cases were diagnosed in the rectum at Dukes B and C, which commonly occurred among middle-aged and elderly Chinese patients. Majority of CRC cases in the young (<50 years old) patients were Malays. Most of the patients received only surgical treatment with anterior resections most frequently performed. There is a definite increasing trend of CRC in particular among young Malay patients for the past 2 decades in Malaysia.