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Cuticular hydrocarbon biosynthesis in malaria vectors: insights from the adult oenocyte transcriptome
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Cuticular hydrocarbon biosynthesis in malaria vectors: insights from the adult oenocyte transcriptome
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Cuticular hydrocarbon biosynthesis in malaria vectors: insights from the adult oenocyte transcriptome
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Paper
Cuticular hydrocarbon biosynthesis in malaria vectors: insights from the adult oenocyte transcriptome
2020
Overview
The surface of insects is coated in cuticular hydrocarbons (CHCs); variations in the composition of this layer affect a range of traits including adaptation to arid environments and defence against pathogens and toxins. In the African malaria vector, Anopheles gambiae quantitative and qualitative variance in CHC composition have been associated with speciation, ecological habitat and insecticide resistance. Understanding how these modifications arise will inform us of how mosquitoes are responding to climate change and vector control interventions. CHCs are synthesised in sub-epidermal cells called oenocytes that are very difficult to isolate from surrounding tissues. Here we utilise a transgenic line with fluorescent oenocytes to purify these cells for the first time. Comparative transcriptomics revealed the enrichment of biological processes related to long chain fatty acyl-CoA biosynthesis and elongation of mono-, poly-unsaturated and saturated fatty acids and enabled us to delineate, and partially validate, the hydrocarbon biosynthetic pathway in An gambiae.
Publisher
Cold Spring Harbor Laboratory Press,Cold Spring Harbor Laboratory
Subject
