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P364 Gardnerella vaginalis clade distribution is associated with behaviours and Nugent score in women who have sex with women
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P364 Gardnerella vaginalis clade distribution is associated with behaviours and Nugent score in women who have sex with women
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Journal Article
P364 Gardnerella vaginalis clade distribution is associated with behaviours and Nugent score in women who have sex with women
2019
Overview
Background Gardnerella vaginalis (GV) can be detected in women with BV and without BV. Identification of four genetically distinct GV-clades (defined using clade-specific genetic markers) led to the hypothesis that there may be both pathogenic and commensal GV-clades. We conducted a study investigating the distribution and behavioural associations of GV-clades in a cohort of women-who-have-sex-with-women (WSW).MethodsWomen self-collected vaginal swabs and completed behavioural questionnaires 3-monthly for 24 months or until incident BV(Nugent Score[NS]=7–10). qPCR assays were used to detect GV and the four GV-clades. Multinomial logistic regression assessed factors associated with number of GV-clades. Generalized estimating equations population-averaged models assessed factors associated with each GV-clade. Models accounted for repeated measures.Results369 specimens from 101 women were analysed. GV was detected in 181 specimens, and most GV-positive specimens had multiple clades present (n=119/181, 66%). Detection of multiple GV-clades was associated with smoking (adjusted relative risk ratio [RRR]:2.52; 95%CI:1.25,5.07), increased lifetime female sex partners (FSP; adjRRR:2.43; 95%CI:1.09,5.38), and a NS=4-6 (intermediate microbiota) or NS=7-10 (Nugent BV) relative to no clades. GV4 was the most prevalent clade (n=136/369; 37%; 95% CI: 32,42%), followed by GV1 (n=116/369; 31%; 95% CI: 27,36%) and GV2 (n=76/369; 21%; 95% CI: 17,25%). GV3 was uncommon (n=17/369; 5%; 95% CI:3,7%). GV1 was associated with a NS=7–10 (adjusted odds ratio[AOR]:3.87; 95%CI:1.75,8.56), smoking (AOR:2.74; 95%CI:1.28,5.87) and report of any sexual partners (AOR:3.41; 95%CI:1.18,9.86). GV2 was associated with NS=4–6 (AOR:3.28; 95%CI:1.00,10.77), sharing of sex-toys (AOR:2.30; 95%CI:1.05,5.04) and recent male sex partners (AOR:6.58; 95%CI:2.02,21.40). GV4 presence was associated with increased lifetime FSPs (AOR:3.17; 95%CI:1.25,5.07).ConclusionGV1 and presence of multiple GV-clades was associated with Nugent BV in WSW, whereas GV2 was associated with intermediate microbiota. Individual GV-clades were associated with a range of differing sexual behaviours in adjusted analyses. These associations are of uncertain importance, but do provide support for exchange of GV-clades between sexual partners.DisclosureNo significant relationships.
Publisher
BMJ Publishing Group LTD
Subject
