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EP439 Predictive value of preoperative serum squamous cell carcinoma antigen (SCC-Ag) level on tumor recurrence in cervical squamous cell carcinoma patients treated with radical surgery: a single-institution study
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EP439 Predictive value of preoperative serum squamous cell carcinoma antigen (SCC-Ag) level on tumor recurrence in cervical squamous cell carcinoma patients treated with radical surgery: a single-institution study
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EP439 Predictive value of preoperative serum squamous cell carcinoma antigen (SCC-Ag) level on tumor recurrence in cervical squamous cell carcinoma patients treated with radical surgery: a single-institution study
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Journal Article
EP439 Predictive value of preoperative serum squamous cell carcinoma antigen (SCC-Ag) level on tumor recurrence in cervical squamous cell carcinoma patients treated with radical surgery: a single-institution study
2019
Overview
Introduction/BackgroundWe seek to find the significance of serum squamous cell carcinoma antigen (SCC-Ag) and the optimal cut-off value for predicting tumor recurrence and survival in cervical squamous cell carcinoma receiving radical surgery.MethodologyA total of 3471 patients with stages IB1 to IIA2 cervical squamous cell carcinoma who underwent radical surgery were enrolled in this study. The cut-off value of serum SCC-Ag for tumor recurrence was calculated using the receiver operating characteristic (ROC) curve. The progression-free survival (PFS) and overall survival (OS) were assessed to estimate the significance of SCC-Ag.ResultsThe optimal cut-off value of serum SCC-Ag level for predicting tumor recurrence was calculated and set at 2.75ng/mL. Compared with 1.5 ng/mL used in clinical practice, serum SCC-Ag level >2.75 ng/mL was closely related to extrapelvic metastatic disease when patients relapse (P=0.035). Multivariate analysis showed that serum SCC-Ag level >1.5 ng/mL and serum SCC-Ag level >2.75 ng/mL were neither independent risk factors for PFS nor OS in all the patients. But in 964 patients with one or more high-risk factors (parametrial invasion, vaginal margin invasion and lymph node metastasis), instead of serum SCC-Ag level >1.5 ng/mL, serum SCC-Ag level >2.75 ng/mL could be used as an independent factor affecting PFS (P=0.018, HR=1.538).ConclusionPreoperative serum SCC-Ag level >2.75 ng/mL is closely related to extrapelvic recurrence, and is an independent factor for tumor recurrence and survival in cervical squamous cell carcinoma patients with high-risk factors.DisclosureNothing to disclose.
Publisher
Elsevier Inc,Elsevier Limited
Subject
